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Engineering of poly([epsi]-caprolactone) microcarriers to modulate protein encapsulation capability and release kinetic

Issue Title: Special Section: Selected Papers from the 21st European Conference on Biomaterials, Brighton, UK, 9-13 September 2007. Guest Editors: Andrew Lloyd and Matteo Santin Drug delivery applications using biodegradable polymeric microspheres are becoming an important means of delivering therap... Full description

Journal Title: Journal of Materials Science : Materials in Medicine Apr 2008, Vol.19(4), pp.1703-11
Main Author: Coccoli, Valentina
Other Authors: Luciani, Alessia , Orsi, Silvia , Guarino, Vincenzo , Causa, Filippo , Netti, Paolo
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 09574530 ; E-ISSN: 15734838 ; DOI: 10.1007/s10856-007-3253-9
Link: http://search.proquest.com/docview/221187160/?pq-origsite=primo
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recordid: proquest221187160
title: Engineering of poly([epsi]-caprolactone) microcarriers to modulate protein encapsulation capability and release kinetic
format: Article
creator:
  • Coccoli, Valentina
  • Luciani, Alessia
  • Orsi, Silvia
  • Guarino, Vincenzo
  • Causa, Filippo
  • Netti, Paolo
subjects:
  • Animals–Methods
  • Cattle–Chemistry
  • Chromatography, Gel–Chemistry
  • Drug Carriers–Chemistry
  • Drug Delivery Systems–Methods
  • Emulsions–Methods
  • Kinetics–Methods
  • Microscopy, Electron, Scanning–Methods
  • Microspheres–Methods
  • Particle Size–Methods
  • Polyesters–Methods
  • Proteins–Methods
  • Serum Albumin, Bovine–Methods
  • Spectrophotometry–Methods
  • Surface-Active Agents–Methods
  • Biomedical Engineering
  • Proteins
  • Kinetics
  • Polymers
  • Chromatography
ispartof: Journal of Materials Science : Materials in Medicine, Apr 2008, Vol.19(4), pp.1703-11
description: Issue Title: Special Section: Selected Papers from the 21st European Conference on Biomaterials, Brighton, UK, 9-13 September 2007. Guest Editors: Andrew Lloyd and Matteo Santin Drug delivery applications using biodegradable polymeric microspheres are becoming an important means of delivering therapeutic agents. The aim of this work was to modulate the microporosity of poly([straight epsilon]-caprolactone) (PCL) microcarriers to control protein loading capability and release profile. PCL microparticles loaded with BSA (bovine serum albumin) have been de novo synthesized with double emulsion solvent evaporation technique transferred and adapted for different polymer concentrations (1.7 and 3% w/v) and stabilizer present in the inner aqueous phase (0.05, 0.5 and 1% w/v). SEM (scanning electron microscope) and CLSM (confocal laser scanning microscope) analysis map the drug distribution in homogeneously distributed cavities inside the microspheres with dimensions that can be modulated by varying...
language: eng
source:
identifier: ISSN: 09574530 ; E-ISSN: 15734838 ; DOI: 10.1007/s10856-007-3253-9
fulltext: fulltext
issn:
  • 09574530
  • 0957-4530
  • 15734838
  • 1573-4838
url: Link


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titleEngineering of poly([epsi]-caprolactone) microcarriers to modulate protein encapsulation capability and release kinetic
creatorCoccoli, Valentina ; Luciani, Alessia ; Orsi, Silvia ; Guarino, Vincenzo ; Causa, Filippo ; Netti, Paolo
ispartofJournal of Materials Science : Materials in Medicine, Apr 2008, Vol.19(4), pp.1703-11
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subjectAnimals–Methods ; Cattle–Chemistry ; Chromatography, Gel–Chemistry ; Drug Carriers–Chemistry ; Drug Delivery Systems–Methods ; Emulsions–Methods ; Kinetics–Methods ; Microscopy, Electron, Scanning–Methods ; Microspheres–Methods ; Particle Size–Methods ; Polyesters–Methods ; Proteins–Methods ; Serum Albumin, Bovine–Methods ; Spectrophotometry–Methods ; Surface-Active Agents–Methods ; Biomedical Engineering ; Proteins ; Kinetics ; Polymers ; Chromatography
descriptionIssue Title: Special Section: Selected Papers from the 21st European Conference on Biomaterials, Brighton, UK, 9-13 September 2007. Guest Editors: Andrew Lloyd and Matteo Santin Drug delivery applications using biodegradable polymeric microspheres are becoming an important means of delivering therapeutic agents. The aim of this work was to modulate the microporosity of poly([straight epsilon]-caprolactone) (PCL) microcarriers to control protein loading capability and release profile. PCL microparticles loaded with BSA (bovine serum albumin) have been de novo synthesized with double emulsion solvent evaporation technique transferred and adapted for different polymer concentrations (1.7 and 3% w/v) and stabilizer present in the inner aqueous phase (0.05, 0.5 and 1% w/v). SEM (scanning electron microscope) and CLSM (confocal laser scanning microscope) analysis map the drug distribution in homogeneously distributed cavities inside the microspheres with dimensions that can be modulated by varying...
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titleEngineering of poly([epsi]-caprolactone) microcarriers to modulate protein encapsulation capability and release kinetic
descriptionIssue Title: Special Section: Selected Papers from the 21st European Conference on Biomaterials, Brighton, UK, 9-13 September 2007. Guest Editors: Andrew Lloyd and Matteo Santin Drug delivery applications using biodegradable polymeric microspheres are becoming an important means of delivering therapeutic agents. The aim of this work was to modulate the microporosity of poly([straight epsilon]-caprolactone) (PCL) microcarriers to control protein loading capability and release profile. PCL microparticles loaded with BSA (bovine serum albumin) have been de novo synthesized with double emulsion solvent evaporation technique transferred and adapted for different polymer concentrations (1.7 and 3% w/v) and stabilizer present in the inner aqueous phase (0.05, 0.5 and 1% w/v). SEM (scanning electron microscope) and CLSM (confocal laser scanning microscope) analysis map the drug distribution in homogeneously distributed cavities inside the microspheres with dimensions that can be modulated by varying...
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titleEngineering of poly([epsi]-caprolactone) microcarriers to modulate protein encapsulation capability and release kinetic
authorCoccoli, Valentina ; Luciani, Alessia ; Orsi, Silvia ; Guarino, Vincenzo ; Causa, Filippo ; Netti, Paolo
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1Cattle–Chemistry
2Chromatography, Gel–Chemistry
3Drug Carriers–Chemistry
4Drug Delivery Systems–Methods
5Emulsions–Methods
6Kinetics–Methods
7Microscopy, Electron, Scanning–Methods
8Microspheres–Methods
9Particle Size–Methods
10Polyesters–Methods
11Proteins–Methods
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12Civil Engineering Abstracts
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15Solid State and Superconductivity Abstracts
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abstractIssue Title: Special Section: Selected Papers from the 21st European Conference on Biomaterials, Brighton, UK, 9-13 September 2007. Guest Editors: Andrew Lloyd and Matteo Santin Drug delivery applications using biodegradable polymeric microspheres are becoming an important means of delivering therapeutic agents. The aim of this work was to modulate the microporosity of poly([straight epsilon]-caprolactone) (PCL) microcarriers to control protein loading capability and release profile. PCL microparticles loaded with BSA (bovine serum albumin) have been de novo synthesized with double emulsion solvent evaporation technique transferred and adapted for different polymer concentrations (1.7 and 3% w/v) and stabilizer present in the inner aqueous phase (0.05, 0.5 and 1% w/v). SEM (scanning electron microscope) and CLSM (confocal laser scanning microscope) analysis map the drug distribution in homogeneously distributed cavities inside the microspheres with dimensions that can be modulated by varying...
copLondon
pubSpringer Nature B.V.
doi10.1007/s10856-007-3253-9
urlhttp://search.proquest.com/docview/221187160/
date2008-04-01