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Osthole prevents tamoxifen-induced liver injury in mice

Abstract Tamoxifen (TMX) is an antiestrogen drug that is used in the treatment and prevention of all stages of estrogen-dependent breast cancer. Adverse effects of TMX include hepatotoxicity. In this study, we investigated the therapeutic effects of osthole, isolated from medicinal plants especially... Full description

Journal Title: Acta Pharmacologica Sinica May 2019, Vol.40(5), pp.608-619
Main Author: Wen-Bo, Zhou
Other Authors: Xin-Xin, Zhang , Cai, Yun , Wu, Sun , Li, Hao
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 16714083 ; E-ISSN: 17457254 ; DOI: 10.1038/s41401-018-0171-y
Link: http://search.proquest.com/docview/2216766232/?pq-origsite=primo
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title: Osthole prevents tamoxifen-induced liver injury in mice
format: Article
creator:
  • Wen-Bo, Zhou
  • Xin-Xin, Zhang
  • Cai, Yun
  • Wu, Sun
  • Li, Hao
subjects:
  • Liver
  • Glutathione
  • Injury Prevention
  • L-Buthionine Sulfoximine
  • N-Acetyl-L-Cysteine
  • Inhibition
  • Medicinal Plants
  • Pretreatment
  • Estrogens
  • Hydrogen Peroxide
  • Oxidative Stress
  • Antioxidants
  • Antioxidants
  • Malondialdehyde
  • Gene Expression
  • Glutathione
  • Oxidative Stress
  • Attenuation
  • Metabolic Activation
  • Cyclic Gmp
ispartof: Acta Pharmacologica Sinica, May 2019, Vol.40(5), pp.608-619
description: Abstract Tamoxifen (TMX) is an antiestrogen drug that is used in the treatment and prevention of all stages of estrogen-dependent breast cancer. Adverse effects of TMX include hepatotoxicity. In this study, we investigated the therapeutic effects of osthole, isolated from medicinal plants especially Fructus Cnidii, on TMX-induced acute liver injury in mice. Mice were injected with osthole (100 mg/kg, ip) or vehicle, followed by TMX (90 mg/kg, ip) 24 h later. We showed that a single injection of TMX-induced liver injury and oxidative stress. Pretreatment with osthole attenuated TMX-induced liver injury evidenced by dose-dependent reduction of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities. Pretreatment with osthole also blunted TMX-induced oxidative stress, evidenced by significant increase of reduced glutathione (GSH) as well as reduction of malondialdehyde (MDA) and hydrogen peroxide (H2O2). Consistently, osthole significantly enhanced the expressions...
language: eng
source:
identifier: ISSN: 16714083 ; E-ISSN: 17457254 ; DOI: 10.1038/s41401-018-0171-y
fulltext: fulltext
issn:
  • 16714083
  • 1671-4083
  • 17457254
  • 1745-7254
url: Link


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titleOsthole prevents tamoxifen-induced liver injury in mice
creatorWen-Bo, Zhou ; Xin-Xin, Zhang ; Cai, Yun ; Wu, Sun ; Li, Hao
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subjectLiver ; Glutathione ; Injury Prevention ; L-Buthionine Sulfoximine ; N-Acetyl-L-Cysteine ; Inhibition ; Medicinal Plants ; Pretreatment ; Estrogens ; Hydrogen Peroxide ; Oxidative Stress ; Antioxidants ; Antioxidants ; Malondialdehyde ; Gene Expression ; Glutathione ; Oxidative Stress ; Attenuation ; Metabolic Activation ; Cyclic Gmp
descriptionAbstract Tamoxifen (TMX) is an antiestrogen drug that is used in the treatment and prevention of all stages of estrogen-dependent breast cancer. Adverse effects of TMX include hepatotoxicity. In this study, we investigated the therapeutic effects of osthole, isolated from medicinal plants especially Fructus Cnidii, on TMX-induced acute liver injury in mice. Mice were injected with osthole (100 mg/kg, ip) or vehicle, followed by TMX (90 mg/kg, ip) 24 h later. We showed that a single injection of TMX-induced liver injury and oxidative stress. Pretreatment with osthole attenuated TMX-induced liver injury evidenced by dose-dependent reduction of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities. Pretreatment with osthole also blunted TMX-induced oxidative stress, evidenced by significant increase of reduced glutathione (GSH) as well as reduction of malondialdehyde (MDA) and hydrogen peroxide (H2O2). Consistently, osthole significantly enhanced the expressions...
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titleOsthole prevents tamoxifen-induced liver injury in mice
descriptionAbstract Tamoxifen (TMX) is an antiestrogen drug that is used in the treatment and prevention of all stages of estrogen-dependent breast cancer. Adverse effects of TMX include hepatotoxicity. In this study, we investigated the therapeutic effects of osthole, isolated from medicinal plants especially Fructus Cnidii, on TMX-induced acute liver injury in mice. Mice were injected with osthole (100 mg/kg, ip) or vehicle, followed by TMX (90 mg/kg, ip) 24 h later. We showed that a single injection of TMX-induced liver injury and oxidative stress. Pretreatment with osthole attenuated TMX-induced liver injury evidenced by dose-dependent reduction of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities. Pretreatment with osthole also blunted TMX-induced oxidative stress, evidenced by significant increase of reduced glutathione (GSH) as well as reduction of malondialdehyde (MDA) and hydrogen peroxide (H2O2). Consistently, osthole significantly enhanced the expressions...
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titleOsthole prevents tamoxifen-induced liver injury in mice
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abstractAbstract Tamoxifen (TMX) is an antiestrogen drug that is used in the treatment and prevention of all stages of estrogen-dependent breast cancer. Adverse effects of TMX include hepatotoxicity. In this study, we investigated the therapeutic effects of osthole, isolated from medicinal plants especially Fructus Cnidii, on TMX-induced acute liver injury in mice. Mice were injected with osthole (100 mg/kg, ip) or vehicle, followed by TMX (90 mg/kg, ip) 24 h later. We showed that a single injection of TMX-induced liver injury and oxidative stress. Pretreatment with osthole attenuated TMX-induced liver injury evidenced by dose-dependent reduction of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities. Pretreatment with osthole also blunted TMX-induced oxidative stress, evidenced by significant increase of reduced glutathione (GSH) as well as reduction of malondialdehyde (MDA) and hydrogen peroxide (H2O2). Consistently, osthole significantly enhanced the expressions...
copShanghai
pubNature Publishing Group
doi10.1038/s41401-018-0171-y
urlhttp://search.proquest.com/docview/2216766232/
date2019-05-01