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Antarctic freshwater microalga, Chloromonas reticulata, suppresses inflammation and carcinogenesis.

Inflammation triggered by the innate immune system is a strategy to protect organisms from the risk of environmental infection. However, it has recently become clear that inflammation can cause a variety of human diseases, including cancer. In this study, we investigated the effects of an et hanol e... Full description

Journal Title: International journal of medical sciences 2019, Vol.16(2), pp.189-197
Main Author: Suh, Sung-Suk
Other Authors: Hong, Ju-Mi , Kim, Eun Jae , Jung, Seung Won , Chae, Hyunsik , Kim, Jung Eun , Kim, Ji Hee , Kim, Il-Chan , Kim, Sanghee
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1449-1907 ; DOI: 10.7150/ijms.30647
Link: http://search.proquest.com/docview/2229092002/?pq-origsite=primo
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recordid: proquest2229092002
title: Antarctic freshwater microalga, Chloromonas reticulata, suppresses inflammation and carcinogenesis.
format: Article
creator:
  • Suh, Sung-Suk
  • Hong, Ju-Mi
  • Kim, Eun Jae
  • Jung, Seung Won
  • Chae, Hyunsik
  • Kim, Jung Eun
  • Kim, Ji Hee
  • Kim, Il-Chan
  • Kim, Sanghee
subjects:
  • Chloromonas Reticulata
  • Hct116
  • Inflammation Cancer
  • Pro-Inflammatory Cytokines
ispartof: International journal of medical sciences, 2019, Vol.16(2), pp.189-197
description: Inflammation triggered by the innate immune system is a strategy to protect organisms from the risk of environmental infection. However, it has recently become clear that inflammation can cause a variety of human diseases, including cancer. In this study, we investigated the effects of an et hanol extract of the Antarctic freshwater microalgae, Ch loromonas reticulata (ETCH), on inflammation and carcinogenesis in RAW 264.7 macrophages and HCT116 human colon cancer cells, respectively. ETCH exhibited significant anti-inflammatory activity through the dose-dependent modulation of major inflammatory markers such as COX-2, IL-6, iNOS, TNF-α, and NO production. For example, ETCH reduced LPS-induced upregulation of COX-2, IL-6, iNOS, and TNF- alpha mRNA levels, leading to a significant decrease in the levels of LPS-stimulated NO and IL-6 as well as TNF-alpha products. In contract, ETCH exhibited dose-dependent cytotoxic activity against HCT116 cells, yielding a profound reduction in the proliferation of the cancer cells. Furthermore, ETCH induced G2 phase cell cycle arrest by transcriptionally regulating of genes involved in G2 / M transition including p21 (CDKN1A), cyclin B1 (CCNB1), and CDK1; CDKN1A mRNA levels were upregulated in response to ETCH, whereas CCNB1 and CDK1 were downregulated. This study reports for the first time anti-inflammatory and anti-cancer effects of, C . reticulata and provides new insights into the molecular mechanisms of the linkage between inflammation and cancer.
language: eng
source:
identifier: E-ISSN: 1449-1907 ; DOI: 10.7150/ijms.30647
fulltext: fulltext
issn:
  • 14491907
  • 1449-1907
url: Link


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titleAntarctic freshwater microalga, Chloromonas reticulata, suppresses inflammation and carcinogenesis.
creatorSuh, Sung-Suk ; Hong, Ju-Mi ; Kim, Eun Jae ; Jung, Seung Won ; Chae, Hyunsik ; Kim, Jung Eun ; Kim, Ji Hee ; Kim, Il-Chan ; Kim, Sanghee
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identifierE-ISSN: 1449-1907 ; DOI: 10.7150/ijms.30647
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descriptionInflammation triggered by the innate immune system is a strategy to protect organisms from the risk of environmental infection. However, it has recently become clear that inflammation can cause a variety of human diseases, including cancer. In this study, we investigated the effects of an et hanol extract of the Antarctic freshwater microalgae, Ch loromonas reticulata (ETCH), on inflammation and carcinogenesis in RAW 264.7 macrophages and HCT116 human colon cancer cells, respectively. ETCH exhibited significant anti-inflammatory activity through the dose-dependent modulation of major inflammatory markers such as COX-2, IL-6, iNOS, TNF-α, and NO production. For example, ETCH reduced LPS-induced upregulation of COX-2, IL-6, iNOS, and TNF- alpha mRNA levels, leading to a significant decrease in the levels of LPS-stimulated NO and IL-6 as well as TNF-alpha products. In contract, ETCH exhibited dose-dependent cytotoxic activity against HCT116 cells, yielding a profound reduction in the proliferation of the cancer cells. Furthermore, ETCH induced G2 phase cell cycle arrest by transcriptionally regulating of genes involved in G2 / M transition including p21 (CDKN1A), cyclin B1 (CCNB1), and CDK1; CDKN1A mRNA levels were upregulated in response to ETCH, whereas CCNB1 and CDK1 were downregulated. This study reports for the first time anti-inflammatory and anti-cancer effects of, C . reticulata and provides new insights into the molecular mechanisms of the linkage between inflammation and cancer.
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