schliessen

Filtern

 

Bibliotheken

Scrobiculosides A and B from the deep-sea sponge Pachastrella scrobiculosa.

Keywords: Scrobiculoside; Deep-sea sponge; Pachastrella scrobiculosa; Cytotoxicity Abstract: Two new steroidal saponins, scrobiculosides A and B, were isolated from the deep-sea sponge Pachastrella scrobiculosa, collected at a depth of 200 m off Miura Peninsula, Japan. The aglycones of scrobiculosid... Full description

Journal Title: Journal of natural medicines September 2019, Vol.73(4), pp.814-819
Main Author: Jomori, Takahiro
Other Authors: Shiroyama, Shuji , Ise, Yuji , Kohtsuka, Hisanori , Matsuda, Kenichi , Kuranaga, Takefumi , Wakimoto, Toshiyuki
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1861-0293 ; DOI: 10.1007/s11418-019-01315-6
Link: http://search.proquest.com/docview/2229230445/?pq-origsite=primo
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: proquest2229230445
title: Scrobiculosides A and B from the deep-sea sponge Pachastrella scrobiculosa.
format: Article
creator:
  • Jomori, Takahiro
  • Shiroyama, Shuji
  • Ise, Yuji
  • Kohtsuka, Hisanori
  • Matsuda, Kenichi
  • Kuranaga, Takefumi
  • Wakimoto, Toshiyuki
subjects:
  • Animals–Metabolism
  • Cell Line, Tumor–Chemistry
  • HL-60 Cells–Isolation & Purification
  • Humans–Pharmacology
  • Japan–Chemistry
  • Molecular Structure–Isolation & Purification
  • Porifera–Pharmacology
  • Saponins–Pharmacology
  • Steroids–Pharmacology
  • Saponins
  • Steroids
  • Cytotoxicity
  • Deep-Sea Sponge
  • Pachastrella Scrobiculosa
  • Scrobiculoside
ispartof: Journal of natural medicines, September 2019, Vol.73(4), pp.814-819
description: Keywords: Scrobiculoside; Deep-sea sponge; Pachastrella scrobiculosa; Cytotoxicity Abstract: Two new steroidal saponins, scrobiculosides A and B, were isolated from the deep-sea sponge Pachastrella scrobiculosa, collected at a depth of 200 m off Miura Peninsula, Japan. The aglycones of scrobiculosides A and B feature a vinylic cyclopropane and a a.sup.24,25 exomethylene on the side chains, respectively. Both saponins have a common sugar moiety composed of [beta]-d-galactopyranosyl-(1[right arrow]2)-6-acetyl-[beta]-d-glucopyranoside, with the exception of an acetyl group on C6a[sup.3] in scrobiculoside A. Scrobiculoside A exhibited cytotoxicity against HL-60 and P388 cells, with IC.sub.50 values of 52 and 61 [micro]M, respectively. Author Affiliation: (1) 0000 0001 2173 7691, grid.39158.36, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan (2) 0000 0001 2294 3534, grid.11875.3a, Center for Marine and Coastal Studies (CEMACS), Universiti Sains Malaysia (USM), 11800, Nibong Tebal, Penang, Malaysia (3) 0000 0001 2151 536X, grid.26999.3d, Misaki Marine Biological Station (MMBS), Graduate School of Science, The University of Tokyo, Misaki, Miura, Kanagawa, 238-0225, Japan Article History: Registration Date: 26/04/2019 Received Date: 02/04/2019 Accepted Date: 26/04/2019 Online Date: 03/05/2019 Article note: Electronic supplementary material The online version of this article ( https://doi.org/10.1007/s11418-019-01315-6) contains supplementary material, which is available to authorized users. Byline: Takahiro Jomori (1), Shuji Shiroyama (1), Yuji Ise (2), Hisanori Kohtsuka (3), Kenichi Matsuda (1), Takefumi Kuranaga (1), Toshiyuki Wakimoto (1)
language: eng
source:
identifier: E-ISSN: 1861-0293 ; DOI: 10.1007/s11418-019-01315-6
fulltext: fulltext
issn:
  • 18610293
  • 1861-0293
url: Link


@attributes
ID1320320026
RANK0.06999999
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid2229230445
sourceidproquest
recordidTN_proquest2229230445
sourcesystemPC
pqid2229230445
galeid597724265
display
typearticle
titleScrobiculosides A and B from the deep-sea sponge Pachastrella scrobiculosa.
creatorJomori, Takahiro ; Shiroyama, Shuji ; Ise, Yuji ; Kohtsuka, Hisanori ; Matsuda, Kenichi ; Kuranaga, Takefumi ; Wakimoto, Toshiyuki
contributorJomori, Takahiro (correspondence author) ; Jomori, Takahiro (record owner)
ispartofJournal of natural medicines, September 2019, Vol.73(4), pp.814-819
identifierE-ISSN: 1861-0293 ; DOI: 10.1007/s11418-019-01315-6
subjectAnimals–Metabolism ; Cell Line, Tumor–Chemistry ; HL-60 Cells–Isolation & Purification ; Humans–Pharmacology ; Japan–Chemistry ; Molecular Structure–Isolation & Purification ; Porifera–Pharmacology ; Saponins–Pharmacology ; Steroids–Pharmacology ; Saponins ; Steroids ; Cytotoxicity ; Deep-Sea Sponge ; Pachastrella Scrobiculosa ; Scrobiculoside
languageeng
source
descriptionKeywords: Scrobiculoside; Deep-sea sponge; Pachastrella scrobiculosa; Cytotoxicity Abstract: Two new steroidal saponins, scrobiculosides A and B, were isolated from the deep-sea sponge Pachastrella scrobiculosa, collected at a depth of 200 m off Miura Peninsula, Japan. The aglycones of scrobiculosides A and B feature a vinylic cyclopropane and a a.sup.24,25 exomethylene on the side chains, respectively. Both saponins have a common sugar moiety composed of [beta]-d-galactopyranosyl-(1[right arrow]2)-6-acetyl-[beta]-d-glucopyranoside, with the exception of an acetyl group on C6a[sup.3] in scrobiculoside A. Scrobiculoside A exhibited cytotoxicity against HL-60 and P388 cells, with IC.sub.50 values of 52 and 61 [micro]M, respectively. Author Affiliation: (1) 0000 0001 2173 7691, grid.39158.36, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan (2) 0000 0001 2294 3534, grid.11875.3a, Center for Marine and Coastal Studies (CEMACS), Universiti Sains Malaysia (USM), 11800, Nibong Tebal, Penang, Malaysia (3) 0000 0001 2151 536X, grid.26999.3d, Misaki Marine Biological Station (MMBS), Graduate School of Science, The University of Tokyo, Misaki, Miura, Kanagawa, 238-0225, Japan Article History: Registration Date: 26/04/2019 Received Date: 02/04/2019 Accepted Date: 26/04/2019 Online Date: 03/05/2019 Article note: Electronic supplementary material The online version of this article ( https://doi.org/10.1007/s11418-019-01315-6) contains supplementary material, which is available to authorized users. Byline: Takahiro Jomori (1), Shuji Shiroyama (1), Yuji Ise (2), Hisanori Kohtsuka (3), Kenichi Matsuda (1), Takefumi Kuranaga (1), Toshiyuki Wakimoto (1)
version6
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://search.proquest.com/docview/2229230445/?pq-origsite=primo$$EView_record_in_ProQuest_(subscribers_only)
search
creatorcontrib
0Jomori, Takahiro
1Shiroyama, Shuji
2Ise, Yuji
3Kohtsuka, Hisanori
4Matsuda, Kenichi
5Kuranaga, Takefumi
6Wakimoto, Toshiyuki
titleScrobiculosides A and B from the deep-sea sponge Pachastrella scrobiculosa.
subject
0Animals–Metabolism
1Cell Line, Tumor–Chemistry
2HL-60 Cells–Isolation & Purification
3Humans–Pharmacology
4Japan–Chemistry
5Molecular Structure–Isolation & Purification
6Porifera–Pharmacology
7Saponins–Pharmacology
8Steroids–Pharmacology
9Saponins
10Steroids
11Cytotoxicity
12Deep-Sea Sponge...
13Deep-sea sponge
14Pachastrella scrobiculosa
15Scrobiculoside
general
0English
110.1007/s11418-019-01315-6
2MEDLINE (ProQuest)
3ProQuest Biological Science Collection
4ProQuest Natural Science Collection
5ProQuest SciTech Collection
6Biological Science Database
7Natural Science Collection
8SciTech Premium Collection
9Health Research Premium Collection
10Health Research Premium Collection (Alumni edition)
11Biological Science Index (ProQuest)
sourceidproquest
recordidproquest2229230445
issn
018610293
11861-0293
rsrctypearticle
creationdate2019
addtitleJournal of natural medicines
searchscope
01007527
11007944
21009130
310000004
410000038
510000050
610000120
710000159
810000238
910000253
1010000260
1110000270
1210000271
1310000302
1410000350
15proquest
scope
01007527
11007944
21009130
310000004
410000038
510000050
610000120
710000159
810000238
910000253
1010000260
1110000270
1210000271
1310000302
1410000350
15proquest
lsr43
01007527false
11007944false
21009130false
310000004false
410000038false
510000050false
610000120false
710000159false
810000238false
910000253false
1010000260false
1110000270false
1210000271false
1310000302false
1410000350false
contributorJomori, Takahiro
startdate20190901
enddate20190901
citationpf 814 pt 819 vol 73 issue 4
lsr30VSR-Enriched:[orcidid, galeid, description, pqid, issn]
sort
titleScrobiculosides A and B from the deep-sea sponge Pachastrella scrobiculosa.
authorJomori, Takahiro ; Shiroyama, Shuji ; Ise, Yuji ; Kohtsuka, Hisanori ; Matsuda, Kenichi ; Kuranaga, Takefumi ; Wakimoto, Toshiyuki
creationdate20190901
lso0120190901
facets
frbrgroupid316623363971578958
frbrtype5
newrecords20190526
languageeng
creationdate2019
topic
0Animals–Metabolism
1Cell Line, Tumor–Chemistry
2HL-60 Cells–Isolation & Purification
3Humans–Pharmacology
4Japan–Chemistry
5Molecular Structure–Isolation & Purification
6Porifera–Pharmacology
7Saponins–Pharmacology
8Steroids–Pharmacology
9Saponins
10Steroids
11Cytotoxicity
12Deep-Sea Sponge...
collection
0MEDLINE (ProQuest)
1ProQuest Biological Science Collection
2ProQuest Natural Science Collection
3ProQuest SciTech Collection
4Biological Science Database
5Natural Science Collection
6SciTech Premium Collection
7Health Research Premium Collection
8Health Research Premium Collection (Alumni edition)
9Biological Science Index (ProQuest)
prefilterarticles
rsrctypearticles
creatorcontrib
0Jomori, Takahiro
1Shiroyama, Shuji
2Ise, Yuji
3Kohtsuka, Hisanori
4Matsuda, Kenichi
5Kuranaga, Takefumi
6Wakimoto, Toshiyuki
jtitleJournal of natural medicines
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Jomori
1Shiroyama
2Ise
3Kohtsuka
4Matsuda
5Kuranaga
6Wakimoto
aufirst
0Takahiro
1Shuji
2Yuji
3Hisanori
4Kenichi
5Takefumi
6Toshiyuki
au
0Jomori, Takahiro
1Shiroyama, Shuji
2Ise, Yuji
3Kohtsuka, Hisanori
4Matsuda, Kenichi
5Kuranaga, Takefumi
6Wakimoto, Toshiyuki
addauJomori, Takahiro
atitleScrobiculosides A and B from the deep-sea sponge Pachastrella scrobiculosa.
jtitleJournal of natural medicines
risdate20190901
volume73
issue4
spage814
epage819
pages814-819
eissn1861-0293
formatjournal
genrearticle
ristypeJOUR
doi10.1007/s11418-019-01315-6
urlhttp://search.proquest.com/docview/2229230445/
orcidid0000-0003-2917-1797
issn13403443
date2019-09-01