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Rho GTPases in A549 and Caco-2 cells dominating the endocytic pathways of nanocarbons with different morphologies

Introduction: Endocytosis of nanomaterials is the first step of nano-bio interaction and current regulation is mostly by nanomaterials but seldom by intracellular signaling proteins. Materials and methods: Herein, we synthesized tubular nanocarbon (oxMWCNT) and lamellar-like nanocarbon (oxGRAPHENE)... Full description

Journal Title: International Journal of Nanomedicine 2018, Vol.13, pp.4391-4404
Main Author: Song, Siyang
Other Authors: Fu, Hongzhe , He, Bing , Wang, Dan , Qin, Mengmeng , Yang, Dan , Liu, Dechun , Song, Ge , Shi, Yujie , Zhang, Hua , Wang, Xueqing , Dai, Wenbing , Zhang, Qiang
Format: Electronic Article Electronic Article
Language: English
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ID: ISSN: 1176-9114 ; E-ISSN: 1178-2013 ; DOI: 10.2147/IJN.S164866
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title: Rho GTPases in A549 and Caco-2 cells dominating the endocytic pathways of nanocarbons with different morphologies
format: Article
creator:
  • Song, Siyang
  • Fu, Hongzhe
  • He, Bing
  • Wang, Dan
  • Qin, Mengmeng
  • Yang, Dan
  • Liu, Dechun
  • Song, Ge
  • Shi, Yujie
  • Zhang, Hua
  • Wang, Xueqing
  • Dai, Wenbing
  • Zhang, Qiang
subjects:
  • Beijing China
  • United States–Us
  • China
  • Laboratories
  • Gene Expression
  • Spectrum Analysis
  • Fourier Transforms
  • Cell Adhesion & Migration
  • Nanoparticles
  • Carbon
  • Permeability
  • Deoxyribonucleic Acid–DNA
  • Nanomaterials
  • Graphene
  • Quantum Dots
  • Kinases
  • Biotechnology
ispartof: International Journal of Nanomedicine, 2018, Vol.13, pp.4391-4404
description: Introduction: Endocytosis of nanomaterials is the first step of nano-bio interaction and current regulation is mostly by nanomaterials but seldom by intracellular signaling proteins. Materials and methods: Herein, we synthesized tubular nanocarbon (oxMWCNT) and lamellar-like nanocarbon (oxGRAPHENE) and formulated their aqueous dispersion. A549 and Caco-2 cells were selected as the models of tumor and intestinal epithelial cells, respectively. After knocking down three members of Rho GTPases (Cdc42, Rac1, RhoA) in these two cell lines, their silencing effects on the uptake pathways of nanomaterials with different morphologies were investigated. Results: An unexpected finding was that the knock-down led to opposite uptake trends in different types of cells. The endocytosis of carbon nanomaterials increased in Caco-2 cells when Rho GTPases were inactivated, while that in A549 cells decreased. For nanomaterials with different shapes, the involved GTPase member of Rho family, or regulating protein...
language: eng
source:
identifier: ISSN: 1176-9114 ; E-ISSN: 1178-2013 ; DOI: 10.2147/IJN.S164866
fulltext: fulltext_linktorsrc
issn:
  • 11769114
  • 1176-9114
  • 11782013
  • 1178-2013
url: Link


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titleRho GTPases in A549 and Caco-2 cells dominating the endocytic pathways of nanocarbons with different morphologies
creatorSong, Siyang ; Fu, Hongzhe ; He, Bing ; Wang, Dan ; Qin, Mengmeng ; Yang, Dan ; Liu, Dechun ; Song, Ge ; Shi, Yujie ; Zhang, Hua ; Wang, Xueqing ; Dai, Wenbing ; Zhang, Qiang
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subjectBeijing China ; United States–Us ; China ; Laboratories ; Gene Expression ; Spectrum Analysis ; Fourier Transforms ; Cell Adhesion & Migration ; Nanoparticles ; Carbon ; Permeability ; Deoxyribonucleic Acid–DNA ; Nanomaterials ; Graphene ; Quantum Dots ; Kinases ; Biotechnology
descriptionIntroduction: Endocytosis of nanomaterials is the first step of nano-bio interaction and current regulation is mostly by nanomaterials but seldom by intracellular signaling proteins. Materials and methods: Herein, we synthesized tubular nanocarbon (oxMWCNT) and lamellar-like nanocarbon (oxGRAPHENE) and formulated their aqueous dispersion. A549 and Caco-2 cells were selected as the models of tumor and intestinal epithelial cells, respectively. After knocking down three members of Rho GTPases (Cdc42, Rac1, RhoA) in these two cell lines, their silencing effects on the uptake pathways of nanomaterials with different morphologies were investigated. Results: An unexpected finding was that the knock-down led to opposite uptake trends in different types of cells. The endocytosis of carbon nanomaterials increased in Caco-2 cells when Rho GTPases were inactivated, while that in A549 cells decreased. For nanomaterials with different shapes, the involved GTPase member of Rho family, or regulating protein...
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descriptionIntroduction: Endocytosis of nanomaterials is the first step of nano-bio interaction and current regulation is mostly by nanomaterials but seldom by intracellular signaling proteins. Materials and methods: Herein, we synthesized tubular nanocarbon (oxMWCNT) and lamellar-like nanocarbon (oxGRAPHENE) and formulated their aqueous dispersion. A549 and Caco-2 cells were selected as the models of tumor and intestinal epithelial cells, respectively. After knocking down three members of Rho GTPases (Cdc42, Rac1, RhoA) in these two cell lines, their silencing effects on the uptake pathways of nanomaterials with different morphologies were investigated. Results: An unexpected finding was that the knock-down led to opposite uptake trends in different types of cells. The endocytosis of carbon nanomaterials increased in Caco-2 cells when Rho GTPases were inactivated, while that in A549 cells decreased. For nanomaterials with different shapes, the involved GTPase member of Rho family, or regulating protein...
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abstractIntroduction: Endocytosis of nanomaterials is the first step of nano-bio interaction and current regulation is mostly by nanomaterials but seldom by intracellular signaling proteins. Materials and methods: Herein, we synthesized tubular nanocarbon (oxMWCNT) and lamellar-like nanocarbon (oxGRAPHENE) and formulated their aqueous dispersion. A549 and Caco-2 cells were selected as the models of tumor and intestinal epithelial cells, respectively. After knocking down three members of Rho GTPases (Cdc42, Rac1, RhoA) in these two cell lines, their silencing effects on the uptake pathways of nanomaterials with different morphologies were investigated. Results: An unexpected finding was that the knock-down led to opposite uptake trends in different types of cells. The endocytosis of carbon nanomaterials increased in Caco-2 cells when Rho GTPases were inactivated, while that in A549 cells decreased. For nanomaterials with different shapes, the involved GTPase member of Rho family, or regulating protein...
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