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Platelets enhance the ability of bone-marrow mesenchymal stem cells to promote cancer metastasis

Background: Bone marrow-derived mesenchymal stem cells (BM-MSCs) have been identified to be closely associated with cancer progression. Our previous experimental results showed that BM-MSCs promote tumor growth and metastasis of gastric cancer through paracrine-soluble cytokines or exosomes. However... Full description

Journal Title: OncoTargets and Therapy 2018, Vol.11, pp.8251-8263
Main Author: Wang, Qianqian
Other Authors: Li, Zhuqian , Sun, Li , Chen, Bin , Zhao, Yuanyuan , Shen, Bo , Zhu, Miaolin , Zhao, Xiangdong , Xu, Changgen , Wang, Mei , Xu, Wenrong , Zhu, Wei
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1178-6930 ; DOI: 10.2147/OTT.S181673
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title: Platelets enhance the ability of bone-marrow mesenchymal stem cells to promote cancer metastasis
format: Article
creator:
  • Wang, Qianqian
  • Li, Zhuqian
  • Sun, Li
  • Chen, Bin
  • Zhao, Yuanyuan
  • Shen, Bo
  • Zhu, Miaolin
  • Zhao, Xiangdong
  • Xu, Changgen
  • Wang, Mei
  • Xu, Wenrong
  • Zhu, Wei
subjects:
  • United States–Us
  • China
  • Glycoproteins
  • Metastasis
  • Leukemia
  • Fibroblasts
  • Cancer Therapies
  • Stomach Cancer
  • Blood Platelets
  • Bone Marrow
  • Flow Cytometry
  • Stem Cells
  • Angiogenesis
  • Proteins
  • Mesenchymal Stem Cells
  • Platelets
  • Gastric Cancer
  • Metastasis
  • Bone Marrow
ispartof: OncoTargets and Therapy, 2018, Vol.11, pp.8251-8263
description: Background: Bone marrow-derived mesenchymal stem cells (BM-MSCs) have been identified to be closely associated with cancer progression. Our previous experimental results showed that BM-MSCs promote tumor growth and metastasis of gastric cancer through paracrine-soluble cytokines or exosomes. However, the elements that affect the role of BM-MSCs in promoting tumor metastasis are not clear. It is known that thrombocytosis in cancer patients is very common. Recently, platelets are recognized to play a critical role in tumor progression. Purpose: This study aims to observe the effect of BM-MSCs which were co-cultured with platelets on tumor cell metastasis. Methods: Platelet aggregation rate and the expression of P-selectin of platelets co-incubated with conditioned medium of SGC-7901 cells and BM-MSCs were detected by flow cytometry and platelet aggregometer. We also analyzed the change of BM-MSCs after co-incubation with platelets or platelets which were treated with SGC-7901 cells using...
language: eng
source:
identifier: E-ISSN: 1178-6930 ; DOI: 10.2147/OTT.S181673
fulltext: fulltext_linktorsrc
issn:
  • 11786930
  • 1178-6930
url: Link


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titlePlatelets enhance the ability of bone-marrow mesenchymal stem cells to promote cancer metastasis
creatorWang, Qianqian ; Li, Zhuqian ; Sun, Li ; Chen, Bin ; Zhao, Yuanyuan ; Shen, Bo ; Zhu, Miaolin ; Zhao, Xiangdong ; Xu, Changgen ; Wang, Mei ; Xu, Wenrong ; Zhu, Wei
ispartofOncoTargets and Therapy, 2018, Vol.11, pp.8251-8263
identifierE-ISSN: 1178-6930 ; DOI: 10.2147/OTT.S181673
subjectUnited States–Us ; China ; Glycoproteins ; Metastasis ; Leukemia ; Fibroblasts ; Cancer Therapies ; Stomach Cancer ; Blood Platelets ; Bone Marrow ; Flow Cytometry ; Stem Cells ; Angiogenesis ; Proteins ; Mesenchymal Stem Cells ; Platelets ; Gastric Cancer ; Metastasis ; Bone Marrow
descriptionBackground: Bone marrow-derived mesenchymal stem cells (BM-MSCs) have been identified to be closely associated with cancer progression. Our previous experimental results showed that BM-MSCs promote tumor growth and metastasis of gastric cancer through paracrine-soluble cytokines or exosomes. However, the elements that affect the role of BM-MSCs in promoting tumor metastasis are not clear. It is known that thrombocytosis in cancer patients is very common. Recently, platelets are recognized to play a critical role in tumor progression. Purpose: This study aims to observe the effect of BM-MSCs which were co-cultured with platelets on tumor cell metastasis. Methods: Platelet aggregation rate and the expression of P-selectin of platelets co-incubated with conditioned medium of SGC-7901 cells and BM-MSCs were detected by flow cytometry and platelet aggregometer. We also analyzed the change of BM-MSCs after co-incubation with platelets or platelets which were treated with SGC-7901 cells using...
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titlePlatelets enhance the ability of bone-marrow mesenchymal stem cells to promote cancer metastasis
descriptionBackground: Bone marrow-derived mesenchymal stem cells (BM-MSCs) have been identified to be closely associated with cancer progression. Our previous experimental results showed that BM-MSCs promote tumor growth and metastasis of gastric cancer through paracrine-soluble cytokines or exosomes. However, the elements that affect the role of BM-MSCs in promoting tumor metastasis are not clear. It is known that thrombocytosis in cancer patients is very common. Recently, platelets are recognized to play a critical role in tumor progression. Purpose: This study aims to observe the effect of BM-MSCs which were co-cultured with platelets on tumor cell metastasis. Methods: Platelet aggregation rate and the expression of P-selectin of platelets co-incubated with conditioned medium of SGC-7901 cells and BM-MSCs were detected by flow cytometry and platelet aggregometer. We also analyzed the change of BM-MSCs after co-incubation with platelets or platelets which were treated with SGC-7901 cells using...
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titlePlatelets enhance the ability of bone-marrow mesenchymal stem cells to promote cancer metastasis
authorWang, Qianqian ; Li, Zhuqian ; Sun, Li ; Chen, Bin ; Zhao, Yuanyuan ; Shen, Bo ; Zhu, Miaolin ; Zhao, Xiangdong ; Xu, Changgen ; Wang, Mei ; Xu, Wenrong ; Zhu, Wei
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abstractBackground: Bone marrow-derived mesenchymal stem cells (BM-MSCs) have been identified to be closely associated with cancer progression. Our previous experimental results showed that BM-MSCs promote tumor growth and metastasis of gastric cancer through paracrine-soluble cytokines or exosomes. However, the elements that affect the role of BM-MSCs in promoting tumor metastasis are not clear. It is known that thrombocytosis in cancer patients is very common. Recently, platelets are recognized to play a critical role in tumor progression. Purpose: This study aims to observe the effect of BM-MSCs which were co-cultured with platelets on tumor cell metastasis. Methods: Platelet aggregation rate and the expression of P-selectin of platelets co-incubated with conditioned medium of SGC-7901 cells and BM-MSCs were detected by flow cytometry and platelet aggregometer. We also analyzed the change of BM-MSCs after co-incubation with platelets or platelets which were treated with SGC-7901 cells using...
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