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Regulating intracellular fate of siRNA by endoplasmic reticulum membrane-decorated hybrid nanoplexes

Most cationic vectors are difficult to avoid the fate of small interfering RNA (siRNA) degradation following the endosome-lysosome pathway during siRNA transfection. In this study, the endoplasmic reticulum (ER) membrane isolated from cancer cells was...

Journal Title: Nature Communications Jun 2019, Vol.10, pp.1-14
Main Author: Qiu, Chong
Other Authors: Hu-Hu, Han , Sun, Jing , Hai-Tao, Zhang , Wei, Wei , Shi-He, Cui , Chen, Xin , Jian-Cheng, Wang , Zhang, Qiang
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 20411723 ; DOI: 10.1038/s41467-019-10562-w
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title: Regulating intracellular fate of siRNA by endoplasmic reticulum membrane-decorated hybrid nanoplexes
format: Article
creator:
  • Qiu, Chong
  • Hu-Hu, Han
  • Sun, Jing
  • Hai-Tao, Zhang
  • Wei, Wei
  • Shi-He, Cui
  • Chen, Xin
  • Jian-Cheng, Wang
  • Zhang, Qiang
subjects:
  • Gene Silencing
  • Endoplasmic Reticulum
  • Endoplasmic Reticulum
  • Golgi Apparatus
  • Antitumor Activity
  • Sirna
  • Anticancer Properties
  • Trafficking
  • Endoplasmic Reticulum
  • Decoration
  • Degradation
  • In Vivo Methods and Tests
  • Transfection
  • Intracellular
  • Lysosomes
ispartof: Nature Communications, Jun 2019, Vol.10, pp.1-14
description: Most cationic vectors are difficult to avoid the fate of small interfering RNA (siRNA) degradation following the endosome-lysosome pathway during siRNA transfection. In this study, the endoplasmic reticulum (ER) membrane isolated from cancer cells was...
language: eng
source:
identifier: E-ISSN: 20411723 ; DOI: 10.1038/s41467-019-10562-w
fulltext: fulltext_linktorsrc
issn:
  • 20411723
  • 2041-1723
url: Link


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titleRegulating intracellular fate of siRNA by endoplasmic reticulum membrane-decorated hybrid nanoplexes
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ispartofNature Communications, Jun 2019, Vol.10, pp.1-14
identifierE-ISSN: 20411723 ; DOI: 10.1038/s41467-019-10562-w
subjectGene Silencing ; Endoplasmic Reticulum ; Endoplasmic Reticulum ; Golgi Apparatus ; Antitumor Activity ; Sirna ; Anticancer Properties ; Trafficking ; Endoplasmic Reticulum ; Decoration ; Degradation ; In Vivo Methods and Tests ; Transfection ; Intracellular ; Lysosomes
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titleRegulating intracellular fate of siRNA by endoplasmic reticulum membrane-decorated hybrid nanoplexes
authorQiu, Chong ; Hu-Hu, Han ; Sun, Jing ; Hai-Tao, Zhang ; Wei, Wei ; Shi-He, Cui ; Chen, Xin ; Jian-Cheng, Wang ; Zhang, Qiang
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abstractMost cationic vectors are difficult to avoid the fate of small interfering RNA (siRNA) degradation following the endosome-lysosome pathway during siRNA transfection. In this study, the endoplasmic reticulum (ER) membrane isolated from cancer cells was...
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doi10.1038/s41467-019-10562-w
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