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Associations Between Linoleic Acid Intake and Incident Type 2 Diabetes Among U.S. Men and Women

OBJECTIVE To investigate the association between intakes of n-6 polyunsaturated fatty acids (PUFAs) and type 2 diabetes risk in three prospective cohort studies of U.S. men and women. RESEARCH DESIGN AND METHODS We followed 83,648 women from the Nurses' Health Study (NHS) (1980–2012), 88,610 women f... Full description

Journal Title: Diabetes Care Aug 1, 2019, Vol.42(8), p.1406
Main Author: Zong, Geng
Other Authors: Liu, Gang , Willett, Walter , Wanders, Anne , Alssema, Marjan , Zock, Peter , Hu, Frank , Sun, Qi
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 01495992 ; DOI: 10.2337/dc19-0412
Link: http://search.proquest.com/docview/2273189696/?pq-origsite=primo
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title: Associations Between Linoleic Acid Intake and Incident Type 2 Diabetes Among U.S. Men and Women
format: Article
creator:
  • Zong, Geng
  • Liu, Gang
  • Willett, Walter
  • Wanders, Anne
  • Alssema, Marjan
  • Zock, Peter
  • Hu, Frank
  • Sun, Qi
subjects:
  • United States–Us
  • Diabetes Mellitus (Non-Insulin Dependent)
  • Diabetes
  • Diet
  • Fatty Acids
  • Fats
  • Carbohydrates
  • Fatty Acids
  • Polyunsaturated Fatty Acids
  • Carbohydrates
  • Risk
  • Carbohydrates
  • Fatty Acids
  • Linoleic Acid
  • Medical Personnel
  • Fatty Acids
  • Questionnaires
  • Diabetes Mellitus
  • Trans Fats
ispartof: Diabetes Care, Aug 1, 2019, Vol.42(8), p.1406
description: OBJECTIVE To investigate the association between intakes of n-6 polyunsaturated fatty acids (PUFAs) and type 2 diabetes risk in three prospective cohort studies of U.S. men and women. RESEARCH DESIGN AND METHODS We followed 83,648 women from the Nurses' Health Study (NHS) (1980–2012), 88,610 women from NHSII (1991–2013), and 41,771 men from the Health Professionals Follow-Up Study (HPFS) (1986–2012). Dietary data were collected every 2–4 years by using validated food-frequency questionnaires. Self-reported incident diabetes, identified biennially, was confirmed by using a validated supplementary questionnaire. RESULTS During 4.93 million person-years of follow-up, 18,442 type 2 diabetes cases were documented. Dietary n-6 PUFAs accounted for 4.4–6.8% of total energy, on average, and consisted primarily of linoleic acid (LA) (≥98%). In multivariate-adjusted models, hazard ratios (95% CIs) of type 2 diabetes risk comparing extreme n-6 PUFA quintiles (highest vs. lowest) were 0.91 (0.85, 0.96)...
language: eng
source:
identifier: ISSN: 01495992 ; DOI: 10.2337/dc19-0412
fulltext: fulltext
issn:
  • 01495992
  • 0149-5992
url: Link


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titleAssociations Between Linoleic Acid Intake and Incident Type 2 Diabetes Among U.S. Men and Women
creatorZong, Geng ; Liu, Gang ; Willett, Walter ; Wanders, Anne ; Alssema, Marjan ; Zock, Peter ; Hu, Frank ; Sun, Qi
ispartofDiabetes Care, Aug 1, 2019, Vol.42(8), p.1406
identifierISSN: 01495992 ; DOI: 10.2337/dc19-0412
subjectUnited States–Us ; Diabetes Mellitus (Non-Insulin Dependent) ; Diabetes ; Diet ; Fatty Acids ; Fats ; Carbohydrates ; Fatty Acids ; Polyunsaturated Fatty Acids ; Carbohydrates ; Risk ; Carbohydrates ; Fatty Acids ; Linoleic Acid ; Medical Personnel ; Fatty Acids ; Questionnaires ; Diabetes Mellitus ; Trans Fats
descriptionOBJECTIVE To investigate the association between intakes of n-6 polyunsaturated fatty acids (PUFAs) and type 2 diabetes risk in three prospective cohort studies of U.S. men and women. RESEARCH DESIGN AND METHODS We followed 83,648 women from the Nurses' Health Study (NHS) (1980–2012), 88,610 women from NHSII (1991–2013), and 41,771 men from the Health Professionals Follow-Up Study (HPFS) (1986–2012). Dietary data were collected every 2–4 years by using validated food-frequency questionnaires. Self-reported incident diabetes, identified biennially, was confirmed by using a validated supplementary questionnaire. RESULTS During 4.93 million person-years of follow-up, 18,442 type 2 diabetes cases were documented. Dietary n-6 PUFAs accounted for 4.4–6.8% of total energy, on average, and consisted primarily of linoleic acid (LA) (≥98%). In multivariate-adjusted models, hazard ratios (95% CIs) of type 2 diabetes risk comparing extreme n-6 PUFA quintiles (highest vs. lowest) were 0.91 (0.85, 0.96)...
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titleAssociations Between Linoleic Acid Intake and Incident Type 2 Diabetes Among U.S. Men and Women
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abstractOBJECTIVE To investigate the association between intakes of n-6 polyunsaturated fatty acids (PUFAs) and type 2 diabetes risk in three prospective cohort studies of U.S. men and women. RESEARCH DESIGN AND METHODS We followed 83,648 women from the Nurses' Health Study (NHS) (1980–2012), 88,610 women from NHSII (1991–2013), and 41,771 men from the Health Professionals Follow-Up Study (HPFS) (1986–2012). Dietary data were collected every 2–4 years by using validated food-frequency questionnaires. Self-reported incident diabetes, identified biennially, was confirmed by using a validated supplementary questionnaire. RESULTS During 4.93 million person-years of follow-up, 18,442 type 2 diabetes cases were documented. Dietary n-6 PUFAs accounted for 4.4–6.8% of total energy, on average, and consisted primarily of linoleic acid (LA) (≥98%). In multivariate-adjusted models, hazard ratios (95% CIs) of type 2 diabetes risk comparing extreme n-6 PUFA quintiles (highest vs. lowest) were 0.91 (0.85, 0.96)...
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date2019-08-01