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Wnt-3a Induces Cytokine Release in Human Mast Cells.

Mast cells are well known for their detrimental effects in allergies and asthma, and Wnt signaling has recently been implicated in asthma and other airway diseases. However, it is not known if or how Wnts affect human mast cells. Since Wnt expression is elevated in individuals with asthma and is lin... Full description

Journal Title: Cells November 1, 2019, Vol.8(11)
Main Author: Tebroke, Julia
Other Authors: Lieverse, Joris E , Säfholm, Jesper , Schulte, Gunnar , Nilsson, Gunnar , Rönnberg, Elin
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 2073-4409 ; DOI: 10.3390/cells8111372
Link: http://search.proquest.com/docview/2312279199/?pq-origsite=primo
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recordid: proquest2312279199
title: Wnt-3a Induces Cytokine Release in Human Mast Cells.
format: Article
creator:
  • Tebroke, Julia
  • Lieverse, Joris E
  • Säfholm, Jesper
  • Schulte, Gunnar
  • Nilsson, Gunnar
  • Rönnberg, Elin
subjects:
  • Ccl8
  • Frizzled
  • Il-8
  • Wnt Signaling
  • Wnt-3a
  • Asthma
  • Mast Cells
ispartof: Cells, November 1, 2019, Vol.8(11)
description: Mast cells are well known for their detrimental effects in allergies and asthma, and Wnt signaling has recently been implicated in asthma and other airway diseases. However, it is not known if or how Wnts affect human mast cells. Since Wnt expression is elevated in individuals with asthma and is linked to a Th2 profile, we hypothesized that mast cells could be affected by Wnts in the context of asthma. We therefore sought to investigate the role of Wnt signaling in human mast cell development and activation. We first examined the expression of the 10 main Wnt receptors, Frizzled 1-10 (FZD(1-10)), and found expression of several FZDs in human mast cells. Treatment with purified recombinant Wnt-3a or Wnt-5a did not affect the proliferation or maturation of CD34(+) progenitors into mast cells, as indicated by cellular expression of CD117 and Fc epsilon RI, activation by Fc epsilon RI crosslinking, and histamine and tryptase release. Furthermore, Wnt treatment did not change the phenotype from...
language: eng
source:
identifier: E-ISSN: 2073-4409 ; DOI: 10.3390/cells8111372
fulltext: fulltext
issn:
  • 20734409
  • 2073-4409
url: Link


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titleWnt-3a Induces Cytokine Release in Human Mast Cells.
creatorTebroke, Julia ; Lieverse, Joris E ; Säfholm, Jesper ; Schulte, Gunnar ; Nilsson, Gunnar ; Rönnberg, Elin
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identifierE-ISSN: 2073-4409 ; DOI: 10.3390/cells8111372
subjectCcl8 ; Frizzled ; Il-8 ; Wnt Signaling ; Wnt-3a ; Asthma ; Mast Cells
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descriptionMast cells are well known for their detrimental effects in allergies and asthma, and Wnt signaling has recently been implicated in asthma and other airway diseases. However, it is not known if or how Wnts affect human mast cells. Since Wnt expression is elevated in individuals with asthma and is linked to a Th2 profile, we hypothesized that mast cells could be affected by Wnts in the context of asthma. We therefore sought to investigate the role of Wnt signaling in human mast cell development and activation. We first examined the expression of the 10 main Wnt receptors, Frizzled 1-10 (FZD(1-10)), and found expression of several FZDs in human mast cells. Treatment with purified recombinant Wnt-3a or Wnt-5a did not affect the proliferation or maturation of CD34(+) progenitors into mast cells, as indicated by cellular expression of CD117 and Fc epsilon RI, activation by Fc epsilon RI crosslinking, and histamine and tryptase release. Furthermore, Wnt treatment did not change the phenotype from...
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