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Short-term exercise training prevents micro- and macrovascular disease following coronary stenting

The purpose of this study was to determine the effects of exercise on coronary blood flow and macrovascular atherosclerosis in response to stent deployment. Male Yucatan swine were placed on a control diet (C); on a high-fat/cholesterol diet (hypercholesterolemic; H); or on a high-fat/cholesterol di... Full description

Journal Title: Journal of Applied Physiology Jun 2010, Vol.108(6), p.1766
Main Author: Long, Xin
Other Authors: Bratz, Ian , Alloosh, Mouhamad , Edwards, Jason , Sturek, Michael
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 87507587 ; E-ISSN: 15221601
Link: http://search.proquest.com/docview/527950392/?pq-origsite=primo
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title: Short-term exercise training prevents micro- and macrovascular disease following coronary stenting
format: Article
creator:
  • Long, Xin
  • Bratz, Ian
  • Alloosh, Mouhamad
  • Edwards, Jason
  • Sturek, Michael
subjects:
  • Physiology
  • Cardiovascular Disease
  • Disease Prevention
  • Coronary Vessels
  • Blood
  • Atherosclerosis
  • Hogs
  • Diet
  • Exercise
ispartof: Journal of Applied Physiology, Jun 2010, Vol.108(6), p.1766
description: The purpose of this study was to determine the effects of exercise on coronary blood flow and macrovascular atherosclerosis in response to stent deployment. Male Yucatan swine were placed on a control diet (C); on a high-fat/cholesterol diet (hypercholesterolemic; H); or on a high-fat/cholesterol diet and aerobically exercise trained (HX) starting after 36 wk on the diet. All pigs underwent coronary angiography and intravascular ultrasound (IVUS) guided placement of a bare metal stent in the circumflex coronary artery after 40 wk on diets and 3 wk later pigs underwent repeat angiography and IVUS and coronary blood flow (CBF) measurement. Average peak velocity (APV) was measured under basal conditions and in response to intracoronary application of the endothelium-independent vasodilator adenosine and the endothelium-dependent vasodilator bradykinin. There was a similar ~8-fold increase in total cholesterol in H and HX compared with control. Baseline CBF was increased above control and H in HX (P < 0.05). At all doses adenosine-induced CBF was impaired in H, but preserved in HX. Similarly, bradykinin-induced CBF was impaired in H vs. control, yet was potentiated in HX. Microvessel density was decreased in H and preserved in HX vs. control. Native atheroma in HX was lower relative to H and control, while in-stent stenosis in HX was not different from H. Hyperlipidemia-induced microvascular dysfunction after stent deployment may be a result of reduction in microvessel density. This is the first report that short-term exercise training near the time of stenting prevents stent-induced microvascular dysfunction and attenuates native atheroma independent of changes in plasma cholesterol in this porcine model. [PUBLICATION ]
language: eng
source:
identifier: ISSN: 87507587 ; E-ISSN: 15221601
fulltext: fulltext
issn:
  • 87507587
  • 8750-7587
  • 15221601
  • 1522-1601
url: Link


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titleShort-term exercise training prevents micro- and macrovascular disease following coronary stenting
creatorLong, Xin ; Bratz, Ian ; Alloosh, Mouhamad ; Edwards, Jason ; Sturek, Michael
ispartofJournal of Applied Physiology, Jun 2010, Vol.108(6), p.1766
identifierISSN: 87507587 ; E-ISSN: 15221601
subjectPhysiology ; Cardiovascular Disease ; Disease Prevention ; Coronary Vessels ; Blood ; Atherosclerosis ; Hogs ; Diet ; Exercise
descriptionThe purpose of this study was to determine the effects of exercise on coronary blood flow and macrovascular atherosclerosis in response to stent deployment. Male Yucatan swine were placed on a control diet (C); on a high-fat/cholesterol diet (hypercholesterolemic; H); or on a high-fat/cholesterol diet and aerobically exercise trained (HX) starting after 36 wk on the diet. All pigs underwent coronary angiography and intravascular ultrasound (IVUS) guided placement of a bare metal stent in the circumflex coronary artery after 40 wk on diets and 3 wk later pigs underwent repeat angiography and IVUS and coronary blood flow (CBF) measurement. Average peak velocity (APV) was measured under basal conditions and in response to intracoronary application of the endothelium-independent vasodilator adenosine and the endothelium-dependent vasodilator bradykinin. There was a similar ~8-fold increase in total cholesterol in H and HX compared with control. Baseline CBF was increased above control and H in HX (P < 0.05). At all doses adenosine-induced CBF was impaired in H, but preserved in HX. Similarly, bradykinin-induced CBF was impaired in H vs. control, yet was potentiated in HX. Microvessel density was decreased in H and preserved in HX vs. control. Native atheroma in HX was lower relative to H and control, while in-stent stenosis in HX was not different from H. Hyperlipidemia-induced microvascular dysfunction after stent deployment may be a result of reduction in microvessel density. This is the first report that short-term exercise training near the time of stenting prevents stent-induced microvascular dysfunction and attenuates native atheroma independent of changes in plasma cholesterol in this porcine model. [PUBLICATION ]
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abstractThe purpose of this study was to determine the effects of exercise on coronary blood flow and macrovascular atherosclerosis in response to stent deployment. Male Yucatan swine were placed on a control diet (C); on a high-fat/cholesterol diet (hypercholesterolemic; H); or on a high-fat/cholesterol diet and aerobically exercise trained (HX) starting after 36 wk on the diet. All pigs underwent coronary angiography and intravascular ultrasound (IVUS) guided placement of a bare metal stent in the circumflex coronary artery after 40 wk on diets and 3 wk later pigs underwent repeat angiography and IVUS and coronary blood flow (CBF) measurement. Average peak velocity (APV) was measured under basal conditions and in response to intracoronary application of the endothelium-independent vasodilator adenosine and the endothelium-dependent vasodilator bradykinin. There was a similar ~8-fold increase in total cholesterol in H and HX compared with control. Baseline CBF was increased above control and H in HX (P < 0.05). At all doses adenosine-induced CBF was impaired in H, but preserved in HX. Similarly, bradykinin-induced CBF was impaired in H vs. control, yet was potentiated in HX. Microvessel density was decreased in H and preserved in HX vs. control. Native atheroma in HX was lower relative to H and control, while in-stent stenosis in HX was not different from H. Hyperlipidemia-induced microvascular dysfunction after stent deployment may be a result of reduction in microvessel density. This is the first report that short-term exercise training near the time of stenting prevents stent-induced microvascular dysfunction and attenuates native atheroma independent of changes in plasma cholesterol in this porcine model. [PUBLICATION ABSTRACT]
copBethesda
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urlhttp://search.proquest.com/docview/527950392/
doi10.1152/japplphysiol.01014.2009
pages1766-74
date2010-06-01