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Differential corticosteroid modulation of inhibitory synaptic currents in the dorsal and ventral hippocampus.

Corticosterone has been known to mediate the effects of stress on cognitive functions associated with the hippocampus. Acting at mineralocorticosteroid receptors (MRs) and glucocorticosteroid receptors (GRs), corticosterone exerts several effects in the hippocampus and elsewhere. Assuming that there... Full description

Journal Title: The Journal of neuroscience : the official journal of the Society for Neuroscience March 4, 2009, Vol.29(9), pp.2857-2866
Main Author: Maggio, Nicola
Other Authors: Segal, Menahem
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1529-2401 ; DOI: 10.1523/JNEUROSCI.4399-08.2009
Link: http://search.proquest.com/docview/66992907/?pq-origsite=primo
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title: Differential corticosteroid modulation of inhibitory synaptic currents in the dorsal and ventral hippocampus.
format: Article
creator:
  • Maggio, Nicola
  • Segal, Menahem
subjects:
  • Adrenal Cortex Hormones–Pharmacology
  • Aldosterone–Pharmacology
  • Animals–Drug Effects
  • Cell Membrane–Physiology
  • Corticosterone–Pharmacology
  • Dexamethasone–Pharmacology
  • Electrophysiology–Drug Effects
  • Excitatory Postsynaptic Potentials–Physiology
  • Hippocampus–Drug Effects
  • Interneurons–Physiology
  • Male–Physiology
  • Neurons–Drug Effects
  • Patch-Clamp Techniques–Physiology
  • Rats–Drug Effects
  • Rats, Wistar–Genetics
  • Receptors, Mineralocorticoid–Physiology
  • Synapses–Drug Effects
  • Gamma-Aminobutyric Acid–Physiology
  • Gamma-Aminobutyric Acid–Physiology
  • Adrenal Cortex Hormones
  • Receptors, Mineralocorticoid
  • Aldosterone
  • Gamma-Aminobutyric Acid
  • Dexamethasone
  • Corticosterone
ispartof: The Journal of neuroscience : the official journal of the Society for Neuroscience, March 4, 2009, Vol.29(9), pp.2857-2866
description: Corticosterone has been known to mediate the effects of stress on cognitive functions associated with the hippocampus. Acting at mineralocorticosteroid receptors (MRs) and glucocorticosteroid receptors (GRs), corticosterone exerts several effects in the hippocampus and elsewhere. Assuming that there are major functional differences between the dorsal hippocampus (DH) and ventral hippocampus (VH), and that these may be regulated by local interneurons, we analyzed the action of corticosterone on inhibitory synaptic currents in patch-clamped pyramidal neurons, recorded in acute slices of DH and VH. Corticosterone, through activation of MRs, reduced the frequency of spontaneous IPSCs in VH but not in DH neurons, and markedly suppressed paired-pulse facilitation of evoked inhibitory synaptic currents. These effects were mimicked by aldosterone, an MR agonist, and were blocked by an MR antagonist. In contrast, corticosterone caused an increase in the magnitude of IPSCs in both the DH and VH via its activation of GRs. This effect was mimicked by a GR agonist, dexamethasone, which produced a slow-onset, large potentiation reaching a peak within 45-60 min after onset of perfusion, and was blocked by a GR antagonist. The amplitude of mIPSCs was markedly increased by the GR agonist, indicating a synaptic locus of effect. These results indicate that corticosterone has a dual action, which may underlie the differential functional effects of stress hormones in the DH and VH.
language: eng
source:
identifier: E-ISSN: 1529-2401 ; DOI: 10.1523/JNEUROSCI.4399-08.2009
fulltext: fulltext
issn:
  • 15292401
  • 1529-2401
url: Link


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titleDifferential corticosteroid modulation of inhibitory synaptic currents in the dorsal and ventral hippocampus.
creatorMaggio, Nicola ; Segal, Menahem
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identifierE-ISSN: 1529-2401 ; DOI: 10.1523/JNEUROSCI.4399-08.2009
subjectAdrenal Cortex Hormones–Pharmacology ; Aldosterone–Pharmacology ; Animals–Drug Effects ; Cell Membrane–Physiology ; Corticosterone–Pharmacology ; Dexamethasone–Pharmacology ; Electrophysiology–Drug Effects ; Excitatory Postsynaptic Potentials–Physiology ; Hippocampus–Drug Effects ; Interneurons–Physiology ; Male–Physiology ; Neurons–Drug Effects ; Patch-Clamp Techniques–Physiology ; Rats–Drug Effects ; Rats, Wistar–Genetics ; Receptors, Mineralocorticoid–Physiology ; Synapses–Drug Effects ; Gamma-Aminobutyric Acid–Physiology ; Gamma-Aminobutyric Acid–Physiology ; Adrenal Cortex Hormones ; Receptors, Mineralocorticoid ; Aldosterone ; Gamma-Aminobutyric Acid ; Dexamethasone ; Corticosterone
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descriptionCorticosterone has been known to mediate the effects of stress on cognitive functions associated with the hippocampus. Acting at mineralocorticosteroid receptors (MRs) and glucocorticosteroid receptors (GRs), corticosterone exerts several effects in the hippocampus and elsewhere. Assuming that there are major functional differences between the dorsal hippocampus (DH) and ventral hippocampus (VH), and that these may be regulated by local interneurons, we analyzed the action of corticosterone on inhibitory synaptic currents in patch-clamped pyramidal neurons, recorded in acute slices of DH and VH. Corticosterone, through activation of MRs, reduced the frequency of spontaneous IPSCs in VH but not in DH neurons, and markedly suppressed paired-pulse facilitation of evoked inhibitory synaptic currents. These effects were mimicked by aldosterone, an MR agonist, and were blocked by an MR antagonist. In contrast, corticosterone caused an increase in the magnitude of IPSCs in both the DH and VH via its activation of GRs. This effect was mimicked by a GR agonist, dexamethasone, which produced a slow-onset, large potentiation reaching a peak within 45-60 min after onset of perfusion, and was blocked by a GR antagonist. The amplitude of mIPSCs was markedly increased by the GR agonist, indicating a synaptic locus of effect. These results indicate that corticosterone has a dual action, which may underlie the differential functional effects of stress hormones in the DH and VH.
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