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Autophagy in health and disease: a double-edged sword.

Autophagy, the process by which cells recycle cytoplasm and dispose of excess or defective organelles, has entered the research spotlight largely owing to the discovery of the protein components that drive this process. Identifying the autophagy genes in yeast and finding orthologs in other organism... Full description

Journal Title: Science (New York N.Y.), November 5, 2004, Vol.306(5698), pp.990-995
Main Author: Shintani, Takahiro
Other Authors: Klionsky, Daniel J
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1095-9203
Link: http://search.proquest.com/docview/67044760/?pq-origsite=primo
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recordid: proquest67044760
title: Autophagy in health and disease: a double-edged sword.
format: Article
creator:
  • Shintani, Takahiro
  • Klionsky, Daniel J
subjects:
  • Animals–Physiology
  • Apoptosis–Physiopathology
  • Autophagy–Physiopathology
  • Humans–Physiopathology
  • Infection–Physiopathology
  • Muscular Diseases–Physiology
  • Neoplasms–Physiology
  • Neurodegenerative Diseases–Physiology
  • Phagosomes–Physiology
ispartof: Science (New York, N.Y.), November 5, 2004, Vol.306(5698), pp.990-995
description: Autophagy, the process by which cells recycle cytoplasm and dispose of excess or defective organelles, has entered the research spotlight largely owing to the discovery of the protein components that drive this process. Identifying the autophagy genes in yeast and finding orthologs in other organisms reveals the conservation of the mechanism of autophagy in eukaryotes and allows the use of molecular genetics and biology in different model systems to study this process. By mostly morphological studies, autophagy has been linked to disease processes. Whether autophagy protects from or causes disease is unclear. Here, we summarize current knowledge about the role of autophagy in disease and health. [PUBLICATION ]
language: eng
source:
identifier: E-ISSN: 1095-9203
fulltext: fulltext
issn:
  • 10959203
  • 1095-9203
url: Link


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descriptionAutophagy, the process by which cells recycle cytoplasm and dispose of excess or defective organelles, has entered the research spotlight largely owing to the discovery of the protein components that drive this process. Identifying the autophagy genes in yeast and finding orthologs in other organisms reveals the conservation of the mechanism of autophagy in eukaryotes and allows the use of molecular genetics and biology in different model systems to study this process. By mostly morphological studies, autophagy has been linked to disease processes. Whether autophagy protects from or causes disease is unclear. Here, we summarize current knowledge about the role of autophagy in disease and health. [PUBLICATION ]
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