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Use of thiazolidinediones does not affect prostate-specific antigen levels in men with diabetes.

Thiazolidinediones (TZD) have been shown to down-regulate prostate-specific antigen (PSA) levels in prostate cancer cell lines and decrease PSA velocity among prostate cancer patients; however, the effect of TZDs on serum PSA levels among men with diabetes at risk for prostate cancer is unknown. We... Full description

Journal Title: Cancer epidemiology biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, June 2009, Vol.18(6), pp.1937-1938
Main Author: Pini, Tunghi M
Other Authors: Griffin, Marie R , Roumie, Christianne L , Huizinga, Mary Margaret , Fowke, Jay H , Greevy, Robert , Liu, Xulei , Murff, Harvey J
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1538-7755 ; DOI: 10.1158/1055-9965.EPI-09-0215
Link: http://search.proquest.com/docview/67338317/?pq-origsite=primo
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title: Use of thiazolidinediones does not affect prostate-specific antigen levels in men with diabetes.
format: Article
creator:
  • Pini, Tunghi M
  • Griffin, Marie R
  • Roumie, Christianne L
  • Huizinga, Mary Margaret
  • Fowke, Jay H
  • Greevy, Robert
  • Liu, Xulei
  • Murff, Harvey J
subjects:
  • Cohort Studies–Drug Therapy
  • Diabetes Mellitus–Therapeutic Use
  • Humans–Blood
  • Hypoglycemic Agents–Drug Effects
  • Male–Blood
  • Middle Aged–Therapeutic Use
  • Prostate-Specific Antigen–Therapeutic Use
  • Prostatic Neoplasms–Therapeutic Use
  • Retrospective Studies–Therapeutic Use
  • Thiazolidinediones–Therapeutic Use
  • Hypoglycemic Agents
  • Thiazolidinediones
  • Prostate-Specific Antigen
ispartof: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, June 2009, Vol.18(6), pp.1937-1938
description: Thiazolidinediones (TZD) have been shown to down-regulate prostate-specific antigen (PSA) levels in prostate cancer cell lines and decrease PSA velocity among prostate cancer patients; however, the effect of TZDs on serum PSA levels among men with diabetes at risk for prostate cancer is unknown. We conducted a retrospective cohort study of veterans receiving care for diabetes between 1999 and 2005 to determine if TZD use affects PSA levels in veterans at risk for prostate cancer. Eligible patients were male, >or=45 years old, taking at least one oral antidiabetic medication, and with two or more recorded PSA values. Patients with a prior history of prostate cancer or prostatectomy were excluded. Of the 13,791 patients included in the adjusted analysis, 2,016 (14.6%) were prescribed a TZD. No effect of cumulative TZD dose on change in PSA was detected (P = 0.26). Increased TZD exposure was not associated with a change in PSA, suggesting that TZD treatment for diabetes is unlikely to affect prostate cancer detection.
language: eng
source:
identifier: E-ISSN: 1538-7755 ; DOI: 10.1158/1055-9965.EPI-09-0215
fulltext: fulltext
issn:
  • 15387755
  • 1538-7755
url: Link


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titleUse of thiazolidinediones does not affect prostate-specific antigen levels in men with diabetes.
creatorPini, Tunghi M ; Griffin, Marie R ; Roumie, Christianne L ; Huizinga, Mary Margaret ; Fowke, Jay H ; Greevy, Robert ; Liu, Xulei ; Murff, Harvey J
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identifierE-ISSN: 1538-7755 ; DOI: 10.1158/1055-9965.EPI-09-0215
subjectCohort Studies–Drug Therapy ; Diabetes Mellitus–Therapeutic Use ; Humans–Blood ; Hypoglycemic Agents–Drug Effects ; Male–Blood ; Middle Aged–Therapeutic Use ; Prostate-Specific Antigen–Therapeutic Use ; Prostatic Neoplasms–Therapeutic Use ; Retrospective Studies–Therapeutic Use ; Thiazolidinediones–Therapeutic Use ; Hypoglycemic Agents ; Thiazolidinediones ; Prostate-Specific Antigen
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descriptionThiazolidinediones (TZD) have been shown to down-regulate prostate-specific antigen (PSA) levels in prostate cancer cell lines and decrease PSA velocity among prostate cancer patients; however, the effect of TZDs on serum PSA levels among men with diabetes at risk for prostate cancer is unknown. We conducted a retrospective cohort study of veterans receiving care for diabetes between 1999 and 2005 to determine if TZD use affects PSA levels in veterans at risk for prostate cancer. Eligible patients were male, >or=45 years old, taking at least one oral antidiabetic medication, and with two or more recorded PSA values. Patients with a prior history of prostate cancer or prostatectomy were excluded. Of the 13,791 patients included in the adjusted analysis, 2,016 (14.6%) were prescribed a TZD. No effect of cumulative TZD dose on change in PSA was detected (P = 0.26). Increased TZD exposure was not associated with a change in PSA, suggesting that TZD treatment for diabetes is unlikely to affect prostate cancer detection.
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