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The Schistosoma japonicum genome reveals features of host-parasite interplay.

Schistosoma japonicum is a parasitic flatworm that causes human schistosomiasis, which is a significant cause of morbidity in China and the Philippines. Here we present a draft genomic sequence for the worm. The genome provides a global insight into the molecular architecture and host interaction of... Full description

Journal Title: Nature July 16, 2009, Vol.460(7253), pp.345-351
Main Author: Zhou, Yan
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1476-4687 ; DOI: 10.1038/nature08140
Link: http://search.proquest.com/docview/67495097/?pq-origsite=primo
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title: The Schistosoma japonicum genome reveals features of host-parasite interplay.
format: Article
creator:
  • Zhou, Yan
subjects:
  • Animals–Metabolism
  • Endocrine System–Genetics
  • Evolution, Molecular–Genetics
  • Gene Duplication–Genetics
  • Genes, Helminth–Metabolism
  • Genome, Helminth–Metabolism
  • Host-Parasite Interactions–Metabolism
  • Immune System–Genetics
  • Inflammation Mediators–Metabolism
  • Molecular Sequence Data–Genetics
  • Nervous System–Embryology
  • Peptide Hydrolases–Enzymology
  • Phylogeny–Genetics
  • Protein Structure, Tertiary–Physiology
  • Schistosoma Japonicum–Genetics
  • Signal Transduction–Genetics
  • Inflammation Mediators
  • Peptide Hydrolases
ispartof: Nature, July 16, 2009, Vol.460(7253), pp.345-351
description: Schistosoma japonicum is a parasitic flatworm that causes human schistosomiasis, which is a significant cause of morbidity in China and the Philippines. Here we present a draft genomic sequence for the worm. The genome provides a global insight into the molecular architecture and host interaction of this complex metazoan pathogen, revealing that it can exploit host nutrients, neuroendocrine hormones and signalling pathways for growth, development and maturation. Having a complex nervous system and a well-developed sensory system, S. japonicum can accept stimulation of the corresponding ligands as a physiological response to different environments, such as fresh water or the tissues of its intermediate and mammalian hosts. Numerous proteases, including cercarial elastase, are implicated in mammalian skin penetration and haemoglobin degradation. The genomic information will serve as a valuable platform to facilitate development of new interventions for schistosomiasis control. [PUBLICATION...
language: eng
source:
identifier: E-ISSN: 1476-4687 ; DOI: 10.1038/nature08140
fulltext: fulltext
issn:
  • 14764687
  • 1476-4687
url: Link


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titleThe Schistosoma japonicum genome reveals features of host-parasite interplay.
creatorZhou, Yan
contributorZheng, Huajun (record owner) ; Chen, Yangyi ; Zhang, Lei ; Wang, Kai ; Guo, Jing ; Huang, Zhen ; Zhang, Bo ; Huang, Wei ; Jin, Ke ; Dou, Tonghai ; Hasegawa, Masami ; Wang, Li ; Zhang, Yuan ; Zhou, Jie ; Tao, Lin ; Cao, Zhiwei ; Li, Yixue ; Vinar, Tomas ; Brejova, Brona ; Brown
ispartofNature, July 16, 2009, Vol.460(7253), pp.345-351
identifierE-ISSN: 1476-4687 ; DOI: 10.1038/nature08140
subjectAnimals–Metabolism ; Endocrine System–Genetics ; Evolution, Molecular–Genetics ; Gene Duplication–Genetics ; Genes, Helminth–Metabolism ; Genome, Helminth–Metabolism ; Host-Parasite Interactions–Metabolism ; Immune System–Genetics ; Inflammation Mediators–Metabolism ; Molecular Sequence Data–Genetics ; Nervous System–Embryology ; Peptide Hydrolases–Enzymology ; Phylogeny–Genetics ; Protein Structure, Tertiary–Physiology ; Schistosoma Japonicum–Genetics ; Signal Transduction–Genetics ; Inflammation Mediators ; Peptide Hydrolases
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descriptionSchistosoma japonicum is a parasitic flatworm that causes human schistosomiasis, which is a significant cause of morbidity in China and the Philippines. Here we present a draft genomic sequence for the worm. The genome provides a global insight into the molecular architecture and host interaction of this complex metazoan pathogen, revealing that it can exploit host nutrients, neuroendocrine hormones and signalling pathways for growth, development and maturation. Having a complex nervous system and a well-developed sensory system, S. japonicum can accept stimulation of the corresponding ligands as a physiological response to different environments, such as fresh water or the tissues of its intermediate and mammalian hosts. Numerous proteases, including cercarial elastase, are implicated in mammalian skin penetration and haemoglobin degradation. The genomic information will serve as a valuable platform to facilitate development of new interventions for schistosomiasis control. [PUBLICATION...
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titleThe Schistosoma japonicum genome reveals features of host-parasite interplay.
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