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Different methods for the detection of small changes in uptake between single-photon emission computed tomography (SPECT) examinations: 99mTc-sestamibi in chemotherapy for breast tumours.

AIMThis study was undertaken to evaluate different methods for the detection of small changes in uptake between single-photon emission computed tomography (SPECT) examinations in the same individual. No standard exists for making digital evaluations at single-photon examinations. For this purpose, w... Full description

Journal Title: Nuclear medicine communications April 2006, Vol.27(4), pp.347-352
Main Author: Jacobsson, Hans
Other Authors: Wilczek, Brigitte , Bergh, Jonas , Von Schoultz, Eva , Eriksson, Elina , Larsson, Stig A
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0143-3636
Link: http://search.proquest.com/docview/67740350/?pq-origsite=primo
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title: Different methods for the detection of small changes in uptake between single-photon emission computed tomography (SPECT) examinations: 99mTc-sestamibi in chemotherapy for breast tumours.
format: Article
creator:
  • Jacobsson, Hans
  • Wilczek, Brigitte
  • Bergh, Jonas
  • Von Schoultz, Eva
  • Eriksson, Elina
  • Larsson, Stig A
subjects:
  • Adult–Therapeutic Use
  • Aged–Therapeutic Use
  • Algorithms–Diagnostic Imaging
  • Antineoplastic Agents–Drug Therapy
  • Antineoplastic Combined Chemotherapy Protocols–Metabolism
  • Breast Neoplasms–Therapeutic Use
  • Cyclophosphamide–Therapeutic Use
  • Epirubicin–Therapeutic Use
  • Female–Methods
  • Fluorouracil–Pharmacokinetics
  • Humans–Pharmacokinetics
  • Image Interpretation, Computer-Assisted–Methods
  • Middle Aged–Methods
  • Prognosis–Methods
  • Radiopharmaceuticals–Methods
  • Reproducibility of Results–Methods
  • Sensitivity and Specificity–Methods
  • Signal Processing, Computer-Assisted–Methods
  • Technetium Tc 99m Sestamibi–Methods
  • Tomography, Emission-Computed, Single-Photon–Methods
  • Treatment Outcome–Methods
  • Antineoplastic Agents
  • Radiopharmaceuticals
  • Epirubicin
  • Cyclophosphamide
  • Technetium Tc 99m Sestamibi
  • Fluorouracil
ispartof: Nuclear medicine communications, April 2006, Vol.27(4), pp.347-352
description: AIMThis study was undertaken to evaluate different methods for the detection of small changes in uptake between single-photon emission computed tomography (SPECT) examinations in the same individual. No standard exists for making digital evaluations at single-photon examinations. For this purpose, we employed a patient cohort from a previous study assessing the response to neoadjuvant chemotherapy for breast cancer using Tc-hexakis-2-methoxyisobutylisonitrile (Tc-sestamibi). METHODSThe tumour uptake in 29 women with locally advanced breast cancer was examined using Tc-sestamibi and SPECT before neoadjuvant chemotherapy and, on average, 19 days after one chemotherapy cycle. The histology of the finally resected tumour confirmed a therapeutic response. Different assessments of the uptake, various levels of background activity subtraction and different reference tissues for relative activity calculations were used. The tumour uptake and activity of the reference tissues were also related to the administered activity. RESULTSDifferent definitions of tumour activity had little influence. Relating the tumour uptake to a large portion of the abdomen, as well as visual evaluation, showed a therapeutic response. Comparison with the administered activity showed that the apparent responses were due to an increased activity of the reference tissues. Referring the tumour uptake to the administered activity truly depicted a therapeutic response. CONCLUSIONSA critical attitude is necessary when making digital evaluations at SPECT. Digital data may seem more relevant than they really are. Relative comparisons may be unreliable. It may be necessary to develop standardized methods for this purpose.
language: eng
source:
identifier: ISSN: 0143-3636
fulltext: fulltext
issn:
  • 01433636
  • 0143-3636
url: Link


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titleDifferent methods for the detection of small changes in uptake between single-photon emission computed tomography (SPECT) examinations: 99mTc-sestamibi in chemotherapy for breast tumours.
creatorJacobsson, Hans ; Wilczek, Brigitte ; Bergh, Jonas ; Von Schoultz, Eva ; Eriksson, Elina ; Larsson, Stig A
contributorJacobsson, Hans (correspondence author) ; Jacobsson, Hans (record owner)
ispartofNuclear medicine communications, April 2006, Vol.27(4), pp.347-352
identifierISSN: 0143-3636
subjectAdult–Therapeutic Use ; Aged–Therapeutic Use ; Algorithms–Diagnostic Imaging ; Antineoplastic Agents–Drug Therapy ; Antineoplastic Combined Chemotherapy Protocols–Metabolism ; Breast Neoplasms–Therapeutic Use ; Cyclophosphamide–Therapeutic Use ; Epirubicin–Therapeutic Use ; Female–Methods ; Fluorouracil–Pharmacokinetics ; Humans–Pharmacokinetics ; Image Interpretation, Computer-Assisted–Methods ; Middle Aged–Methods ; Prognosis–Methods ; Radiopharmaceuticals–Methods ; Reproducibility of Results–Methods ; Sensitivity and Specificity–Methods ; Signal Processing, Computer-Assisted–Methods ; Technetium Tc 99m Sestamibi–Methods ; Tomography, Emission-Computed, Single-Photon–Methods ; Treatment Outcome–Methods ; Antineoplastic Agents ; Radiopharmaceuticals ; Epirubicin ; Cyclophosphamide ; Technetium Tc 99m Sestamibi ; Fluorouracil
descriptionAIMThis study was undertaken to evaluate different methods for the detection of small changes in uptake between single-photon emission computed tomography (SPECT) examinations in the same individual. No standard exists for making digital evaluations at single-photon examinations. For this purpose, we employed a patient cohort from a previous study assessing the response to neoadjuvant chemotherapy for breast cancer using Tc-hexakis-2-methoxyisobutylisonitrile (Tc-sestamibi). METHODSThe tumour uptake in 29 women with locally advanced breast cancer was examined using Tc-sestamibi and SPECT before neoadjuvant chemotherapy and, on average, 19 days after one chemotherapy cycle. The histology of the finally resected tumour confirmed a therapeutic response. Different assessments of the uptake, various levels of background activity subtraction and different reference tissues for relative activity calculations were used. The tumour uptake and activity of the reference tissues were also related to the administered activity. RESULTSDifferent definitions of tumour activity had little influence. Relating the tumour uptake to a large portion of the abdomen, as well as visual evaluation, showed a therapeutic response. Comparison with the administered activity showed that the apparent responses were due to an increased activity of the reference tissues. Referring the tumour uptake to the administered activity truly depicted a therapeutic response. CONCLUSIONSA critical attitude is necessary when making digital evaluations at SPECT. Digital data may seem more relevant than they really are. Relative comparisons may be unreliable. It may be necessary to develop standardized methods for this purpose.
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titleDifferent methods for the detection of small changes in uptake between single-photon emission computed tomography (SPECT) examinations: 99mTc-sestamibi in chemotherapy for breast tumours.
descriptionAIMThis study was undertaken to evaluate different methods for the detection of small changes in uptake between single-photon emission computed tomography (SPECT) examinations in the same individual. No standard exists for making digital evaluations at single-photon examinations. For this purpose, we employed a patient cohort from a previous study assessing the response to neoadjuvant chemotherapy for breast cancer using Tc-hexakis-2-methoxyisobutylisonitrile (Tc-sestamibi). METHODSThe tumour uptake in 29 women with locally advanced breast cancer was examined using Tc-sestamibi and SPECT before neoadjuvant chemotherapy and, on average, 19 days after one chemotherapy cycle. The histology of the finally resected tumour confirmed a therapeutic response. Different assessments of the uptake, various levels of background activity subtraction and different reference tissues for relative activity calculations were used. The tumour uptake and activity of the reference tissues were also related to the administered activity. RESULTSDifferent definitions of tumour activity had little influence. Relating the tumour uptake to a large portion of the abdomen, as well as visual evaluation, showed a therapeutic response. Comparison with the administered activity showed that the apparent responses were due to an increased activity of the reference tissues. Referring the tumour uptake to the administered activity truly depicted a therapeutic response. CONCLUSIONSA critical attitude is necessary when making digital evaluations at SPECT. Digital data may seem more relevant than they really are. Relative comparisons may be unreliable. It may be necessary to develop standardized methods for this purpose.
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13Prognosis–Methods
14Radiopharmaceuticals–Methods
15Reproducibility of Results–Methods
16Sensitivity and Specificity–Methods
17Signal Processing, Computer-Assisted–Methods
18Technetium Tc 99m Sestamibi–Methods
19Tomography, Emission-Computed, Single-Photon–Methods
20Treatment Outcome–Methods
21Antineoplastic Agents
22Radiopharmaceuticals
23Epirubicin
24Cyclophosphamide
25Technetium Tc 99m Sestamibi
26Fluorouracil
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titleDifferent methods for the detection of small changes in uptake between single-photon emission computed tomography (SPECT) examinations: 99mTc-sestamibi in chemotherapy for breast tumours.
authorJacobsson, Hans ; Wilczek, Brigitte ; Bergh, Jonas ; Von Schoultz, Eva ; Eriksson, Elina ; Larsson, Stig A
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7Epirubicin–Therapeutic Use
8Female–Methods
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abstractAIMThis study was undertaken to evaluate different methods for the detection of small changes in uptake between single-photon emission computed tomography (SPECT) examinations in the same individual. No standard exists for making digital evaluations at single-photon examinations. For this purpose, we employed a patient cohort from a previous study assessing the response to neoadjuvant chemotherapy for breast cancer using Tc-hexakis-2-methoxyisobutylisonitrile (Tc-sestamibi). METHODSThe tumour uptake in 29 women with locally advanced breast cancer was examined using Tc-sestamibi and SPECT before neoadjuvant chemotherapy and, on average, 19 days after one chemotherapy cycle. The histology of the finally resected tumour confirmed a therapeutic response. Different assessments of the uptake, various levels of background activity subtraction and different reference tissues for relative activity calculations were used. The tumour uptake and activity of the reference tissues were also related to the administered activity. RESULTSDifferent definitions of tumour activity had little influence. Relating the tumour uptake to a large portion of the abdomen, as well as visual evaluation, showed a therapeutic response. Comparison with the administered activity showed that the apparent responses were due to an increased activity of the reference tissues. Referring the tumour uptake to the administered activity truly depicted a therapeutic response. CONCLUSIONSA critical attitude is necessary when making digital evaluations at SPECT. Digital data may seem more relevant than they really are. Relative comparisons may be unreliable. It may be necessary to develop standardized methods for this purpose.
urlhttp://search.proquest.com/docview/67740350/
doi10.1590/S0004-282X2006000400004
eissn16784227
date2006-04-01