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Reactivation by exon shuffling of a conserved HLA-DR3-like pseudogene segment in a New World primate species.

The common marmoset (Callithrix jacchus), a New World monkey species with a limited MHC class II repertoire, is highly susceptible to certain bacterial infections. Genomic analysis of exon 2 sequences documented the existence of only one DRB region configuration harboring three loci. Two of these lo... Full description

Journal Title: Proceedings of the National Academy of Sciences of the United States of America April 11, 2006, Vol.103(15), pp.5864-5868
Main Author: Doxiadis, Gaby G M
Other Authors: van Der Wiel, Marit K H , Brok, Herbert P M , de Groot, Natasja G , Otting, Nel , 'T Hart, Bert A , van Rood, Jon J , Bontrop, Ronald E
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0027-8424
Link: http://search.proquest.com/docview/67858790/?pq-origsite=primo
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title: Reactivation by exon shuffling of a conserved HLA-DR3-like pseudogene segment in a New World primate species.
format: Article
creator:
  • Doxiadis, Gaby G M
  • van Der Wiel, Marit K H
  • Brok, Herbert P M
  • de Groot, Natasja G
  • Otting, Nel
  • 'T Hart, Bert A
  • van Rood, Jon J
  • Bontrop, Ronald E
subjects:
  • Amino Acid Sequence–Genetics
  • Animals–Genetics
  • Exons–Genetics
  • HLA-Dr3 Antigen–Immunology
  • Histocompatibility Antigens Class II–Immunology
  • Molecular Sequence Data–Immunology
  • Primates–Immunology
  • Pseudogenes–Immunology
  • Sequence Alignment–Immunology
  • Sequence Homology, Amino Acid–Immunology
  • Transcription, Genetic–Immunology
  • HLA-Dr3 Antigen
  • Histocompatibility Antigens Class II
ispartof: Proceedings of the National Academy of Sciences of the United States of America, April 11, 2006, Vol.103(15), pp.5864-5868
description: The common marmoset (Callithrix jacchus), a New World monkey species with a limited MHC class II repertoire, is highly susceptible to certain bacterial infections. Genomic analysis of exon 2 sequences documented the existence of only one DRB region configuration harboring three loci. Two of these loci display moderate levels of allelic polymorphism, whereas the -DRB*W12 gene appears to be monomorphic. This study shows that only the CajaDRB*W16 and -DRB*W12 loci produce functional transcripts. The Caja-DRB1*03 locus is occupied by a pseudogene, given that most of the transcripts, if detected at all, show imperfections and are present at low levels. Moreover, two hybrid transcripts were identified that feature the evolutionarily conserved peptide-binding motif characteristic for the Caja-DRB1*03 gene. Thus, the severely reduced MHC class II repertoire in common marmosets has been expanded by reactivation of a pseudogene segment as a result of exon shuffling. MHC | non-human primates | selection | immune response | evolution
language: eng
source:
identifier: ISSN: 0027-8424
fulltext: fulltext
issn:
  • 00278424
  • 0027-8424
url: Link


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titleReactivation by exon shuffling of a conserved HLA-DR3-like pseudogene segment in a New World primate species.
creatorDoxiadis, Gaby G M ; van Der Wiel, Marit K H ; Brok, Herbert P M ; de Groot, Natasja G ; Otting, Nel ; 'T Hart, Bert A ; van Rood, Jon J ; Bontrop, Ronald E
contributorDoxiadis, Gaby G M (correspondence author) ; Doxiadis, Gaby G M (record owner)
ispartofProceedings of the National Academy of Sciences of the United States of America, April 11, 2006, Vol.103(15), pp.5864-5868
identifierISSN: 0027-8424
subjectAmino Acid Sequence–Genetics ; Animals–Genetics ; Exons–Genetics ; HLA-Dr3 Antigen–Immunology ; Histocompatibility Antigens Class II–Immunology ; Molecular Sequence Data–Immunology ; Primates–Immunology ; Pseudogenes–Immunology ; Sequence Alignment–Immunology ; Sequence Homology, Amino Acid–Immunology ; Transcription, Genetic–Immunology ; HLA-Dr3 Antigen ; Histocompatibility Antigens Class II
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descriptionThe common marmoset (Callithrix jacchus), a New World monkey species with a limited MHC class II repertoire, is highly susceptible to certain bacterial infections. Genomic analysis of exon 2 sequences documented the existence of only one DRB region configuration harboring three loci. Two of these loci display moderate levels of allelic polymorphism, whereas the -DRB*W12 gene appears to be monomorphic. This study shows that only the CajaDRB*W16 and -DRB*W12 loci produce functional transcripts. The Caja-DRB1*03 locus is occupied by a pseudogene, given that most of the transcripts, if detected at all, show imperfections and are present at low levels. Moreover, two hybrid transcripts were identified that feature the evolutionarily conserved peptide-binding motif characteristic for the Caja-DRB1*03 gene. Thus, the severely reduced MHC class II repertoire in common marmosets has been expanded by reactivation of a pseudogene segment as a result of exon shuffling. MHC | non-human primates | selection | immune response | evolution
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titleReactivation by exon shuffling of a conserved HLA-DR3-like pseudogene segment in a New World primate species.
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titleReactivation by exon shuffling of a conserved HLA-DR3-like pseudogene segment in a New World primate species.
authorDoxiadis, Gaby G M ; van Der Wiel, Marit K H ; Brok, Herbert P M ; de Groot, Natasja G ; Otting, Nel ; 'T Hart, Bert A ; van Rood, Jon J ; Bontrop, Ronald E
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