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Palmerolide A, a cytotoxic macrolide from the antarctic tunicate Synoicum adareanum.

Palmerolide A, a 20-membered macrocyclic polyketide bearing carbamate and vinyl amide functionality, was isolated from the tunicate Synoicum adareanum collected from the vicinity of Palmer Station on the Antarctic Peninsula. Palmerolide A displays potent and selective cytotoxicity toward melanoma (U... Full description

Journal Title: Journal of the American Chemical Society May 3, 2006, Vol.128(17), pp.5630-5631
Main Author: Diyabalanage, Thushara
Other Authors: Amsler, Charles D , Mcclintock, James B , Baker, Bill J
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0002-7863
Link: http://search.proquest.com/docview/67904855/?pq-origsite=primo
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recordid: proquest67904855
title: Palmerolide A, a cytotoxic macrolide from the antarctic tunicate Synoicum adareanum.
format: Article
creator:
  • Diyabalanage, Thushara
  • Amsler, Charles D
  • Mcclintock, James B
  • Baker, Bill J
subjects:
  • Animals–Chemistry
  • Antineoplastic Agents–Isolation & Purification
  • Drug Screening Assays, Antitumor–Pharmacology
  • Macrolides–Chemistry
  • Magnetic Resonance Spectroscopy–Isolation & Purification
  • Models, Molecular–Pharmacology
  • Spectrometry, Mass, Fast Atom Bombardment–Chemistry
  • Urochordata–Chemistry
  • Antineoplastic Agents
  • Macrolides
  • Palmerolide A
ispartof: Journal of the American Chemical Society, May 3, 2006, Vol.128(17), pp.5630-5631
description: Palmerolide A, a 20-membered macrocyclic polyketide bearing carbamate and vinyl amide functionality, was isolated from the tunicate Synoicum adareanum collected from the vicinity of Palmer Station on the Antarctic Peninsula. Palmerolide A displays potent and selective cytotoxicity toward melanoma (UACC-66 LC50 = 0.018 muM) and appears to operate via inhibition (IC50 = 2 nM) of V-ATPase.
language: eng
source:
identifier: ISSN: 0002-7863
fulltext: no_fulltext
issn:
  • 00027863
  • 0002-7863
url: Link


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titlePalmerolide A, a cytotoxic macrolide from the antarctic tunicate Synoicum adareanum.
creatorDiyabalanage, Thushara ; Amsler, Charles D ; Mcclintock, James B ; Baker, Bill J
contributorDiyabalanage, Thushara (correspondence author) ; Diyabalanage, Thushara (record owner)
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subjectAnimals–Chemistry ; Antineoplastic Agents–Isolation & Purification ; Drug Screening Assays, Antitumor–Pharmacology ; Macrolides–Chemistry ; Magnetic Resonance Spectroscopy–Isolation & Purification ; Models, Molecular–Pharmacology ; Spectrometry, Mass, Fast Atom Bombardment–Chemistry ; Urochordata–Chemistry ; Antineoplastic Agents ; Macrolides ; Palmerolide A
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descriptionPalmerolide A, a 20-membered macrocyclic polyketide bearing carbamate and vinyl amide functionality, was isolated from the tunicate Synoicum adareanum collected from the vicinity of Palmer Station on the Antarctic Peninsula. Palmerolide A displays potent and selective cytotoxicity toward melanoma (UACC-66 LC50 = 0.018 muM) and appears to operate via inhibition (IC50 = 2 nM) of V-ATPase.
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