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TCR alpha genes direct MHC restriction in the potent human T cell response to a class I-bound viral epitope.

The underlying generic properties of alphabeta TCRs that control MHC restriction remain largely unresolved. To investigate MHC restriction, we have examined the CTL response to a viral epitope that binds promiscuously to two human leukocyte Ags (HLAs) that differ by a single amino acid at position 1... Full description

Journal Title: Journal of immunology (Baltimore Md. : 1950), November 15, 2006, Vol.177(10), pp.6804-6814
Main Author: Miles, John J
Other Authors: Borg, Natalie A , Brennan, Rebekah M , Tynan, Fleur E , Kjer-Nielsen, Lars , Silins, Sharon L , Bell, Melissa J , Burrows, Jacqueline M , Mccluskey, James , Rossjohn, Jamie , Burrows, Scott R
Format: Electronic Article Electronic Article
Language: English
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ID: ISSN: 0022-1767
Link: http://search.proquest.com/docview/68105994/?pq-origsite=primo
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title: TCR alpha genes direct MHC restriction in the potent human T cell response to a class I-bound viral epitope.
format: Article
creator:
  • Miles, John J
  • Borg, Natalie A
  • Brennan, Rebekah M
  • Tynan, Fleur E
  • Kjer-Nielsen, Lars
  • Silins, Sharon L
  • Bell, Melissa J
  • Burrows, Jacqueline M
  • Mccluskey, James
  • Rossjohn, Jamie
  • Burrows, Scott R
subjects:
  • Amino Acid Sequence–Genetics
  • Antigen Presentation–Genetics
  • Cell Line, Transformed–Immunology
  • Cells, Cultured–Metabolism
  • Crystallography, X-Ray–Immunology
  • Cytotoxicity, Immunologic–Metabolism
  • Epitopes, T-Lymphocyte–Genetics
  • Epstein-Barr Virus Nuclear Antigens–Immunology
  • HLA Antigens–Metabolism
  • HLA-B Antigens–Metabolism
  • HLA-B35 Antigen–Genetics
  • Histocompatibility Antigens Class I–Immunology
  • Humans–Metabolism
  • Molecular Sequence Data–Genetics
  • Protein Binding–Immunology
  • Protein Subunits–Biosynthesis
  • Receptors, Antigen, T-Cell, Alpha-Beta–Genetics
  • T-Lymphocytes, Cytotoxic–Physiology
  • T-Lymphocytes, Cytotoxic–Biosynthesis
  • T-Lymphocytes, Cytotoxic–Genetics
  • T-Lymphocytes, Cytotoxic–Physiology
  • T-Lymphocytes, Cytotoxic–Immunology
  • T-Lymphocytes, Cytotoxic–Metabolism
  • T-Lymphocytes, Cytotoxic–Virology
  • Abridged
  • Epitopes, T-Lymphocyte
  • Epstein-Barr Virus Nuclear Antigens
  • HLA Antigens
  • HLA-B Antigens
  • HLA-B*35:01 Antigen
  • HLA-B35 Antigen
  • Histocompatibility Antigens Class I
  • Protein Subunits
  • Receptors, Antigen, T-Cell, Alpha-Beta
  • Ebv-Encoded Nuclear Antigen 1
ispartof: Journal of immunology (Baltimore, Md. : 1950), November 15, 2006, Vol.177(10), pp.6804-6814
description: The underlying generic properties of alphabeta TCRs that control MHC restriction remain largely unresolved. To investigate MHC restriction, we have examined the CTL response to a viral epitope that binds promiscuously to two human leukocyte Ags (HLAs) that differ by a single amino acid at position 156. Individuals expressing either HLA-B*3501 (156Leucine) or HLA-B*3508 (156Arginine) showed a potent CTL response to the 407HPVGEADYFEY417 epitope from EBV. Interestingly, the response was characterized by highly restricted TCR beta-chain usage in both HLA-B*3501+ and HLA-B*3508+ individuals; however, this conserved TRBV9+ beta-chain was associated with distinct TCR alpha-chains depending upon the HLA-B*35 allele expressed by the virus-exposed host. Functional assays confirmed that TCR alpha-chain usage determined the HLA restriction of the CTLs. Structural studies revealed significant differences in the mobility of the peptide when bound to HLA-B*3501 or HLA-B*3508. In HLA-B*3501, the bulged...
language: eng
source:
identifier: ISSN: 0022-1767
fulltext: fulltext
issn:
  • 00221767
  • 0022-1767
url: Link


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titleTCR alpha genes direct MHC restriction in the potent human T cell response to a class I-bound viral epitope.
creatorMiles, John J ; Borg, Natalie A ; Brennan, Rebekah M ; Tynan, Fleur E ; Kjer-Nielsen, Lars ; Silins, Sharon L ; Bell, Melissa J ; Burrows, Jacqueline M ; Mccluskey, James ; Rossjohn, Jamie ; Burrows, Scott R
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ispartofJournal of immunology (Baltimore, Md. : 1950), November 15, 2006, Vol.177(10), pp.6804-6814
identifierISSN: 0022-1767
subjectAmino Acid Sequence–Genetics ; Antigen Presentation–Genetics ; Cell Line, Transformed–Immunology ; Cells, Cultured–Metabolism ; Crystallography, X-Ray–Immunology ; Cytotoxicity, Immunologic–Metabolism ; Epitopes, T-Lymphocyte–Genetics ; Epstein-Barr Virus Nuclear Antigens–Immunology ; HLA Antigens–Metabolism ; HLA-B Antigens–Metabolism ; HLA-B35 Antigen–Genetics ; Histocompatibility Antigens Class I–Immunology ; Humans–Metabolism ; Molecular Sequence Data–Genetics ; Protein Binding–Immunology ; Protein Subunits–Biosynthesis ; Receptors, Antigen, T-Cell, Alpha-Beta–Genetics ; T-Lymphocytes, Cytotoxic–Physiology ; T-Lymphocytes, Cytotoxic–Biosynthesis ; T-Lymphocytes, Cytotoxic–Genetics ; T-Lymphocytes, Cytotoxic–Physiology ; T-Lymphocytes, Cytotoxic–Immunology ; T-Lymphocytes, Cytotoxic–Metabolism ; T-Lymphocytes, Cytotoxic–Virology ; Abridged ; Epitopes, T-Lymphocyte ; Epstein-Barr Virus Nuclear Antigens ; HLA Antigens ; HLA-B Antigens ; HLA-B*35:01 Antigen ; HLA-B35 Antigen ; Histocompatibility Antigens Class I ; Protein Subunits ; Receptors, Antigen, T-Cell, Alpha-Beta ; Ebv-Encoded Nuclear Antigen 1
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descriptionThe underlying generic properties of alphabeta TCRs that control MHC restriction remain largely unresolved. To investigate MHC restriction, we have examined the CTL response to a viral epitope that binds promiscuously to two human leukocyte Ags (HLAs) that differ by a single amino acid at position 156. Individuals expressing either HLA-B*3501 (156Leucine) or HLA-B*3508 (156Arginine) showed a potent CTL response to the 407HPVGEADYFEY417 epitope from EBV. Interestingly, the response was characterized by highly restricted TCR beta-chain usage in both HLA-B*3501+ and HLA-B*3508+ individuals; however, this conserved TRBV9+ beta-chain was associated with distinct TCR alpha-chains depending upon the HLA-B*35 allele expressed by the virus-exposed host. Functional assays confirmed that TCR alpha-chain usage determined the HLA restriction of the CTLs. Structural studies revealed significant differences in the mobility of the peptide when bound to HLA-B*3501 or HLA-B*3508. In HLA-B*3501, the bulged...
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6Bell, Melissa J
7Burrows, Jacqueline M
8Mccluskey, James
9Rossjohn, Jamie
10Burrows, Scott R
titleTCR alpha genes direct MHC restriction in the potent human T cell response to a class I-bound viral epitope.
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1Antigen Presentation–Genetics
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3Cells, Cultured–Metabolism
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6Epitopes, T-Lymphocyte–Genetics
7Epstein-Barr Virus Nuclear Antigens–Immunology
8HLA Antigens–Metabolism
9HLA-B Antigens–Metabolism
10HLA-B35 Antigen–Genetics
11Histocompatibility Antigens Class I–Immunology
12Humans–Metabolism
13Molecular Sequence Data–Genetics
14Protein Binding–Immunology
15Protein Subunits–Biosynthesis
16Receptors, Antigen, T-Cell, Alpha-Beta–Genetics
17T-Lymphocytes, Cytotoxic–Physiology
18T-Lymphocytes, Cytotoxic–Biosynthesis
19T-Lymphocytes, Cytotoxic–Genetics
20T-Lymphocytes, Cytotoxic–Immunology
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titleTCR alpha genes direct MHC restriction in the potent human T cell response to a class I-bound viral epitope.
authorMiles, John J ; Borg, Natalie A ; Brennan, Rebekah M ; Tynan, Fleur E ; Kjer-Nielsen, Lars ; Silins, Sharon L ; Bell, Melissa J ; Burrows, Jacqueline M ; Mccluskey, James ; Rossjohn, Jamie ; Burrows, Scott R
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3Cells, Cultured–Metabolism
4Crystallography, X-Ray–Immunology
5Cytotoxicity, Immunologic–Metabolism
6Epitopes, T-Lymphocyte–Genetics
7Epstein-Barr Virus Nuclear Antigens–Immunology
8HLA Antigens–Metabolism
9HLA-B Antigens–Metabolism
10HLA-B35 Antigen–Genetics
11Histocompatibility Antigens Class I–Immunology
12Humans–Metabolism
13Molecular Sequence Data–Genetics
14Protein Binding–Immunology
15Protein Subunits–Biosynthesis
16Receptors, Antigen, T-Cell, Alpha-Beta–Genetics
17T-Lymphocytes, Cytotoxic–Physiology
18T-Lymphocytes, Cytotoxic–Biosynthesis
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21T-Lymphocytes, Cytotoxic–Metabolism
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