schliessen

Filtern

 

Bibliotheken

Synaptic plasticity (and the lack thereof) in hippocampal CA2 neurons.

The hippocampus is critical for some forms of memory and spatial navigation, but previous research has mostly neglected the CA2, a unique region situated between CA3 and CA1. Here, we show that CA2 pyramidal neurons have distinctive physiological characteristics that include an unprecedented synapti... Full description

Journal Title: The Journal of neuroscience : the official journal of the Society for Neuroscience October 31, 2007, Vol.27(44), pp.12025-12032
Main Author: Zhao, Meilan
Other Authors: Choi, Yun-Sik , Obrietan, Karl , Dudek, Serena M
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1529-2401
Link: http://search.proquest.com/docview/68472250/?pq-origsite=primo
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: proquest68472250
title: Synaptic plasticity (and the lack thereof) in hippocampal CA2 neurons.
format: Article
creator:
  • Zhao, Meilan
  • Choi, Yun-Sik
  • Obrietan, Karl
  • Dudek, Serena M
subjects:
  • Animals–Methods
  • Animals, Newborn–Drug Effects
  • Disease Models, Animal–Physiology
  • Dose-Response Relationship, Radiation–Radiation Effects
  • Electric Stimulation–Cytology
  • Excitatory Postsynaptic Potentials–Physiology
  • Hippocampus–Radiation Effects
  • In Vitro Techniques–Physiology
  • Long-Term Potentiation–Radiation Effects
  • Male–Physiology
  • Mice–Methods
  • Mice, Inbred C57bl–Chemically Induced
  • Neuronal Plasticity–Physiopathology
  • Neurons–Drug Effects
  • Patch-Clamp Techniques–Physiology
  • Rats–Radiation Effects
  • Rats, Sprague-Dawley–Radiation Effects
  • Status Epilepticus–Radiation Effects
  • Synaptic Transmission–Radiation Effects
ispartof: The Journal of neuroscience : the official journal of the Society for Neuroscience, October 31, 2007, Vol.27(44), pp.12025-12032
description: The hippocampus is critical for some forms of memory and spatial navigation, but previous research has mostly neglected the CA2, a unique region situated between CA3 and CA1. Here, we show that CA2 pyramidal neurons have distinctive physiological characteristics that include an unprecedented synaptic stability. Although basal synaptic currents in CA1 and CA2 are quite similar, synaptic plasticity including long-term potentiation and long-term depression is absent or less likely to be induced with conventional methods of stimulation in CA2. We also find that CA2 neurons have larger leak currents and more negative resting membrane potentials than CA1 neurons, and consequently, more current is required for action potential generation in CA2 neurons. These data suggest that the molecular "conspiracy against plasticity" in CA2 makes it functionally distinct from the other hippocampal CA regions. This work provides critical insight into hippocampal function and may lead to an understanding of the resistance of CA2 to damage from disease, trauma, and hypoxia.
language: eng
source:
identifier: E-ISSN: 1529-2401
fulltext: fulltext
issn:
  • 15292401
  • 1529-2401
url: Link


@attributes
ID1644279238
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid68472250
sourceidproquest
recordidTN_proquest68472250
sourcesystemPC
pqid68472250
display
typearticle
titleSynaptic plasticity (and the lack thereof) in hippocampal CA2 neurons.
creatorZhao, Meilan ; Choi, Yun-Sik ; Obrietan, Karl ; Dudek, Serena M
contributorZhao, Meilan (correspondence author) ; Zhao, Meilan (record owner)
ispartofThe Journal of neuroscience : the official journal of the Society for Neuroscience, October 31, 2007, Vol.27(44), pp.12025-12032
identifierE-ISSN: 1529-2401
subjectAnimals–Methods ; Animals, Newborn–Drug Effects ; Disease Models, Animal–Physiology ; Dose-Response Relationship, Radiation–Radiation Effects ; Electric Stimulation–Cytology ; Excitatory Postsynaptic Potentials–Physiology ; Hippocampus–Radiation Effects ; In Vitro Techniques–Physiology ; Long-Term Potentiation–Radiation Effects ; Male–Physiology ; Mice–Methods ; Mice, Inbred C57bl–Chemically Induced ; Neuronal Plasticity–Physiopathology ; Neurons–Drug Effects ; Patch-Clamp Techniques–Physiology ; Rats–Radiation Effects ; Rats, Sprague-Dawley–Radiation Effects ; Status Epilepticus–Radiation Effects ; Synaptic Transmission–Radiation Effects
languageeng
source
descriptionThe hippocampus is critical for some forms of memory and spatial navigation, but previous research has mostly neglected the CA2, a unique region situated between CA3 and CA1. Here, we show that CA2 pyramidal neurons have distinctive physiological characteristics that include an unprecedented synaptic stability. Although basal synaptic currents in CA1 and CA2 are quite similar, synaptic plasticity including long-term potentiation and long-term depression is absent or less likely to be induced with conventional methods of stimulation in CA2. We also find that CA2 neurons have larger leak currents and more negative resting membrane potentials than CA1 neurons, and consequently, more current is required for action potential generation in CA2 neurons. These data suggest that the molecular "conspiracy against plasticity" in CA2 makes it functionally distinct from the other hippocampal CA regions. This work provides critical insight into hippocampal function and may lead to an understanding of the resistance of CA2 to damage from disease, trauma, and hypoxia.
version4
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://search.proquest.com/docview/68472250/?pq-origsite=primo$$EView_record_in_ProQuest_(subscribers_only)
search
creatorcontrib
0Zhao, Meilan
1Choi, Yun-Sik
2Obrietan, Karl
3Dudek, Serena M
titleSynaptic plasticity (and the lack thereof) in hippocampal CA2 neurons.
subject
0Animals–Methods
1Animals, Newborn–Drug Effects
2Disease Models, Animal–Physiology
3Dose-Response Relationship, Radiation–Radiation Effects
4Electric Stimulation–Cytology
5Excitatory Postsynaptic Potentials–Physiology
6Hippocampus–Radiation Effects
7In Vitro Techniques–Physiology
8Long-Term Potentiation–Radiation Effects
9Male–Physiology
10Mice–Methods
11Mice, Inbred C57bl–Chemically Induced
12Neuronal Plasticity–Physiopathology
13Neurons–Drug Effects
14Patch-Clamp Techniques–Physiology
15Rats–Radiation Effects
16Rats, Sprague-Dawley–Radiation Effects
17Status Epilepticus–Radiation Effects
18Synaptic Transmission–Radiation Effects
general
0English
1MEDLINE (ProQuest)
2ProQuest Biological Science Collection
3ProQuest Environmental Science Collection
4ProQuest Natural Science Collection
5ProQuest SciTech Collection
6Agricultural & Environmental Science Database
7Biological Science Database
8Natural Science Collection
9SciTech Premium Collection
10Health Research Premium Collection
11Health Research Premium Collection (Alumni edition)
12Environmental Science Index (ProQuest)
13Biological Science Index (ProQuest)
14Environmental Science Collection (ProQuest)
sourceidproquest
recordidproquest68472250
issn
015292401
11529-2401
rsrctypearticle
creationdate2007
addtitleThe Journal of neuroscience : the official journal of the Society for Neuroscience
searchscope
01007489
11007527
21007944
31009130
410000004
510000006
610000038
710000043
810000050
910000120
1010000159
1110000198
1210000200
1310000209
1410000217
1510000234
1610000238
1710000253
1810000260
1910000270
2010000271
2110000302
2210000349
2310000350
2410000354
25proquest
scope
01007489
11007527
21007944
31009130
410000004
510000006
610000038
710000043
810000050
910000120
1010000159
1110000198
1210000200
1310000209
1410000217
1510000234
1610000238
1710000253
1810000260
1910000270
2010000271
2110000302
2210000349
2310000350
2410000354
25proquest
lsr43
01007489false
11007527false
21007944false
31009130false
410000004false
510000006false
610000038false
710000043false
810000050false
910000120false
1010000159false
1110000198false
1210000200false
1310000209false
1410000217false
1510000234false
1610000238false
1710000253false
1810000260false
1910000270false
2010000271false
2110000302false
2210000349false
2310000350false
2410000354false
contributorZhao, Meilan
startdate20071031
enddate20071031
citationpf 12025 pt 12032 vol 27 issue 44
lsr30VSR-Enriched:[description, doi, pqid, issn]
sort
titleSynaptic plasticity (and the lack thereof) in hippocampal CA2 neurons.
authorZhao, Meilan ; Choi, Yun-Sik ; Obrietan, Karl ; Dudek, Serena M
creationdate20071031
lso0120071031
facets
frbrgroupid8978607673096529355
frbrtype5
newrecords20181218
languageeng
creationdate2007
topic
0Animals–Methods
1Animals, Newborn–Drug Effects
2Disease Models, Animal–Physiology
3Dose-Response Relationship, Radiation–Radiation Effects
4Electric Stimulation–Cytology
5Excitatory Postsynaptic Potentials–Physiology
6Hippocampus–Radiation Effects
7In Vitro Techniques–Physiology
8Long-Term Potentiation–Radiation Effects
9Male–Physiology
10Mice–Methods
11Mice, Inbred C57bl–Chemically Induced
12Neuronal Plasticity–Physiopathology
13Neurons–Drug Effects
14Patch-Clamp Techniques–Physiology
15Rats–Radiation Effects
16Rats, Sprague-Dawley–Radiation Effects
17Status Epilepticus–Radiation Effects
18Synaptic Transmission–Radiation Effects
collection
0MEDLINE (ProQuest)
1ProQuest Biological Science Collection
2ProQuest Environmental Science Collection
3ProQuest Natural Science Collection
4ProQuest SciTech Collection
5Agricultural & Environmental Science Database
6Biological Science Database
7Natural Science Collection
8SciTech Premium Collection
9Health Research Premium Collection
10Health Research Premium Collection (Alumni edition)
11Environmental Science Index (ProQuest)
12Biological Science Index (ProQuest)
13Environmental Science Collection (ProQuest)
prefilterarticles
rsrctypearticles
creatorcontrib
0Zhao, Meilan
1Choi, Yun-Sik
2Obrietan, Karl
3Dudek, Serena M
jtitleJournal of neuroscience : the official journal of the Society for Neuroscience
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Zhao
1Choi
2Obrietan
3Dudek
aufirst
0Meilan
1Yun-Sik
2Karl
3Serena M
au
0Zhao, Meilan
1Choi, Yun-Sik
2Obrietan, Karl
3Dudek, Serena M
addauZhao, Meilan
atitleSynaptic plasticity (and the lack thereof) in hippocampal CA2 neurons.
jtitleThe Journal of neuroscience : the official journal of the Society for Neuroscience
risdate20071031
volume27
issue44
spage12025
epage12032
pages12025-12032
eissn1529-2401
formatjournal
genrearticle
ristypeJOUR
urlhttp://search.proquest.com/docview/68472250/
doi10.1523/JNEUROSCI.4094-07.2007
issn02706474
date2007-10-31