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Liposomal or nanoparticle alpha-TEA reduced 66cl-4 murine mammary cancer burden and metastasis.

Efficacy of alpha-TEA formulated in liposome or biodegradable poly(D, L-lactide-co-glycolide) (PLGA) nanoparticle was evaluated in a BALB/c clone 66cl-4 mammary cancer mouse model using oral delivery. alpha-TEA-loaded liposome or nanoparticle at 5 mg, but not 2.5 mg/day, significantly reduced tumor... Full description

Journal Title: Drug delivery November 2007, Vol.14(8), pp.497-505
Main Author: Wang, Pei
Other Authors: Jia, Li , Sanders, Bob G , Kline, Kimberly
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1071-7544
Link: http://search.proquest.com/docview/68526950/?pq-origsite=primo
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title: Liposomal or nanoparticle alpha-TEA reduced 66cl-4 murine mammary cancer burden and metastasis.
format: Article
creator:
  • Wang, Pei
  • Jia, Li
  • Sanders, Bob G
  • Kline, Kimberly
subjects:
  • Administration, Oral–Administration & Dosage
  • Animals–Chemistry
  • Antineoplastic Agents–Therapeutic Use
  • Apoptosis–Drug Effects
  • Body Weight–Drug Effects
  • Cell Line, Tumor–Chemistry
  • Female–Chemical Synthesis
  • Lactic Acid–Chemistry
  • Liposomes–Prevention & Control
  • Lung Neoplasms–Secondary
  • Lymph Nodes–Drug Effects
  • Lymphocytes–Pathology
  • Mammary Neoplasms, Experimental–Drug Effects
  • Mice–Pathology
  • Mice, Inbred Balb C–Drug Therapy
  • Nanoparticles–Pathology
  • Particle Size–Chemistry
  • Phosphatidylcholines–Chemistry
  • Polyglycolic Acid–Chemistry
  • Polylactic Acid-Polyglycolic Acid Copolymer–Chemistry
  • Polymers–Administration & Dosage
  • Tocopherols–Chemistry
  • Tumor Burden–Therapeutic Use
  • Tumor Burden–Drug Effects
  • Antineoplastic Agents
  • Liposomes
  • Phosphatidylcholines
  • Polymers
  • 1,2-Dilauroylphosphatidylcholine
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Polyglycolic Acid
  • Lactic Acid
  • 2,5,7,8-Tetramethyl-2r-(4r,8r,12-Trimethyltridecyl)Chroman-6-Yloxy Acetic Acid
  • Tocopherols
ispartof: Drug delivery, November 2007, Vol.14(8), pp.497-505
description: Efficacy of alpha-TEA formulated in liposome or biodegradable poly(D, L-lactide-co-glycolide) (PLGA) nanoparticle was evaluated in a BALB/c clone 66cl-4 mammary cancer mouse model using oral delivery. alpha-TEA-loaded liposome or nanoparticle at 5 mg, but not 2.5 mg/day, significantly reduced tumor burden (p < 0.001). Both formulations at 5 mg significantly reduced visible lung metastases and lymph node and lung micrometastatic tumor foci. Surprisingly, nanoparticle control mice exhibited significantly reduced tumor burden, lymph node, and lung micrometastatic tumor foci. Both formulations at 5 mg significantly enhanced tumor apoptosis. In summary, liposomes and nanoparticles are effective means for administering the lipophilic anticancer drug alpha-TEA.
language: eng
source:
identifier: ISSN: 1071-7544
fulltext: fulltext
issn:
  • 10717544
  • 1071-7544
url: Link


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titleLiposomal or nanoparticle alpha-TEA reduced 66cl-4 murine mammary cancer burden and metastasis.
creatorWang, Pei ; Jia, Li ; Sanders, Bob G ; Kline, Kimberly
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ispartofDrug delivery, November 2007, Vol.14(8), pp.497-505
identifierISSN: 1071-7544
subjectAdministration, Oral–Administration & Dosage ; Animals–Chemistry ; Antineoplastic Agents–Therapeutic Use ; Apoptosis–Drug Effects ; Body Weight–Drug Effects ; Cell Line, Tumor–Chemistry ; Female–Chemical Synthesis ; Lactic Acid–Chemistry ; Liposomes–Prevention & Control ; Lung Neoplasms–Secondary ; Lymph Nodes–Drug Effects ; Lymphocytes–Pathology ; Mammary Neoplasms, Experimental–Drug Effects ; Mice–Pathology ; Mice, Inbred Balb C–Drug Therapy ; Nanoparticles–Pathology ; Particle Size–Chemistry ; Phosphatidylcholines–Chemistry ; Polyglycolic Acid–Chemistry ; Polylactic Acid-Polyglycolic Acid Copolymer–Chemistry ; Polymers–Administration & Dosage ; Tocopherols–Chemistry ; Tumor Burden–Therapeutic Use ; Tumor Burden–Drug Effects ; Antineoplastic Agents ; Liposomes ; Phosphatidylcholines ; Polymers ; 1,2-Dilauroylphosphatidylcholine ; Polylactic Acid-Polyglycolic Acid Copolymer ; Polyglycolic Acid ; Lactic Acid ; 2,5,7,8-Tetramethyl-2r-(4r,8r,12-Trimethyltridecyl)Chroman-6-Yloxy Acetic Acid ; Tocopherols
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descriptionEfficacy of alpha-TEA formulated in liposome or biodegradable poly(D, L-lactide-co-glycolide) (PLGA) nanoparticle was evaluated in a BALB/c clone 66cl-4 mammary cancer mouse model using oral delivery. alpha-TEA-loaded liposome or nanoparticle at 5 mg, but not 2.5 mg/day, significantly reduced tumor burden (p < 0.001). Both formulations at 5 mg significantly reduced visible lung metastases and lymph node and lung micrometastatic tumor foci. Surprisingly, nanoparticle control mice exhibited significantly reduced tumor burden, lymph node, and lung micrometastatic tumor foci. Both formulations at 5 mg significantly enhanced tumor apoptosis. In summary, liposomes and nanoparticles are effective means for administering the lipophilic anticancer drug alpha-TEA.
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titleLiposomal or nanoparticle alpha-TEA reduced 66cl-4 murine mammary cancer burden and metastasis.
authorWang, Pei ; Jia, Li ; Sanders, Bob G ; Kline, Kimberly
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2Antineoplastic Agents–Therapeutic Use
3Apoptosis–Drug Effects
4Body Weight–Drug Effects
5Cell Line, Tumor–Chemistry
6Female–Chemical Synthesis
7Lactic Acid–Chemistry
8Liposomes–Prevention & Control
9Lung Neoplasms–Secondary
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13Mice–Pathology
14Mice, Inbred Balb C–Drug Therapy
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17Phosphatidylcholines–Chemistry
18Polyglycolic Acid–Chemistry
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281,2-Dilauroylphosphatidylcholine
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