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Liposomes and micro/nanoparticles as colloidal carriers for nasal drug delivery.

The use of the nasal route for drug delivery has attracted much interest in recent years in the pharmaceutical field. Local and principally systemic drug delivery can be achieved by this route of administration. But the nasal route of delivery is not applicable to all drugs. Polar drugs and some mac... Full description

Journal Title: Current drug delivery July 2006, Vol.3(3), pp.275-285
Main Author: Mainardes, Rubiana Mara
Other Authors: Urban, Maria Cristina Cocenza , Cinto, Priscila Oliveira , Chaud, Marco Vinícius , Evangelista, Raul Cesar , Gremião, Maria Palmira Daflon
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1567-2018
Link: http://search.proquest.com/docview/68654634/?pq-origsite=primo
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recordid: proquest68654634
title: Liposomes and micro/nanoparticles as colloidal carriers for nasal drug delivery.
format: Article
creator:
  • Mainardes, Rubiana Mara
  • Urban, Maria Cristina Cocenza
  • Cinto, Priscila Oliveira
  • Chaud, Marco Vinícius
  • Evangelista, Raul Cesar
  • Gremião, Maria Palmira Daflon
subjects:
  • Administration, Intranasal–Chemistry
  • Animals–Methods
  • Biological Availability–Chemistry
  • Colloids–Chemistry
  • Drug Carriers–Administration & Dosage
  • Drug Delivery Systems–Chemistry
  • Humans–Pharmacokinetics
  • Liposomes–Pharmacokinetics
  • Nanostructures–Pharmacokinetics
  • Vaccines–Pharmacokinetics
  • Colloids
  • Drug Carriers
  • Liposomes
  • Vaccines
ispartof: Current drug delivery, July 2006, Vol.3(3), pp.275-285
description: The use of the nasal route for drug delivery has attracted much interest in recent years in the pharmaceutical field. Local and principally systemic drug delivery can be achieved by this route of administration. But the nasal route of delivery is not applicable to all drugs. Polar drugs and some macromolecules are not absorbed in sufficient concentration due to poor membrane permeability, rapid clearance and enzymatic degradation into the nasal cavity. Thus, alternative means that help overcome these nasal barriers are currently in development. Absorption enhancers such as phospholipids and surfactants are constantly used, but care must be taken in relation to their concentration. Drug delivery systems including liposomes, cyclodextrins, micro- and nanoparticles are being investigated to increase the bioavailability of drugs delivered intranasally. This review article discusses recent progress and specific development issues relating to colloidal drug delivery systems in nasal drug delivery.
language: eng
source:
identifier: ISSN: 1567-2018
fulltext: fulltext
issn:
  • 15672018
  • 1567-2018
url: Link


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titleLiposomes and micro/nanoparticles as colloidal carriers for nasal drug delivery.
creatorMainardes, Rubiana Mara ; Urban, Maria Cristina Cocenza ; Cinto, Priscila Oliveira ; Chaud, Marco Vinícius ; Evangelista, Raul Cesar ; Gremião, Maria Palmira Daflon
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identifierISSN: 1567-2018
subjectAdministration, Intranasal–Chemistry ; Animals–Methods ; Biological Availability–Chemistry ; Colloids–Chemistry ; Drug Carriers–Administration & Dosage ; Drug Delivery Systems–Chemistry ; Humans–Pharmacokinetics ; Liposomes–Pharmacokinetics ; Nanostructures–Pharmacokinetics ; Vaccines–Pharmacokinetics ; Colloids ; Drug Carriers ; Liposomes ; Vaccines
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descriptionThe use of the nasal route for drug delivery has attracted much interest in recent years in the pharmaceutical field. Local and principally systemic drug delivery can be achieved by this route of administration. But the nasal route of delivery is not applicable to all drugs. Polar drugs and some macromolecules are not absorbed in sufficient concentration due to poor membrane permeability, rapid clearance and enzymatic degradation into the nasal cavity. Thus, alternative means that help overcome these nasal barriers are currently in development. Absorption enhancers such as phospholipids and surfactants are constantly used, but care must be taken in relation to their concentration. Drug delivery systems including liposomes, cyclodextrins, micro- and nanoparticles are being investigated to increase the bioavailability of drugs delivered intranasally. This review article discusses recent progress and specific development issues relating to colloidal drug delivery systems in nasal drug delivery.
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