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Nanoscale coordination polymers for platinum-based anticancer drug delivery.

Pt-containing nanoscale coordination polymer (NCP) particles with the formula of Tb sub(2)(DSCP) sub(3)(H sub(2)O) sub(12) (where DSCP represents disuccinatocisplatin), NCP-1, were precipitated from an aqueous solution of Tb super(3+) ions and DSCP bridging ligands via the addition of a poor solvent... Full description

Journal Title: Journal of the American Chemical Society September 3, 2008, Vol.130(35), pp.11584-11585
Main Author: Rieter, William J
Other Authors: Pott, Kimberly M , Taylor, Kathryn M L , Lin, Wenbin
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1520-5126 ; DOI: 10.1021/ja803383k
Link: http://search.proquest.com/docview/69475764/?pq-origsite=primo
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recordid: proquest69475764
title: Nanoscale coordination polymers for platinum-based anticancer drug delivery.
format: Article
creator:
  • Rieter, William J
  • Pott, Kimberly M
  • Taylor, Kathryn M L
  • Lin, Wenbin
subjects:
  • Antineoplastic Agents–Administration & Dosage
  • Cisplatin–Chemistry
  • Colorectal Neoplasms–Administration & Dosage
  • Delayed-Action Preparations–Analogs & Derivatives
  • Drug Delivery Systems–Drug Therapy
  • Ht29 Cells–Methods
  • Humans–Chemistry
  • Models, Molecular–Administration & Dosage
  • Nanostructures–Chemistry
  • Silicon Dioxide–Chemistry
  • Terbium–Chemistry
  • X-Ray Diffraction–Chemistry
  • Antineoplastic Agents
  • Delayed-Action Preparations
  • Terbium
  • Silicon Dioxide
  • Terbium Chloride
  • Cisplatin
ispartof: Journal of the American Chemical Society, September 3, 2008, Vol.130(35), pp.11584-11585
description: Pt-containing nanoscale coordination polymer (NCP) particles with the formula of Tb sub(2)(DSCP) sub(3)(H sub(2)O) sub(12) (where DSCP represents disuccinatocisplatin), NCP-1, were precipitated from an aqueous solution of Tb super(3+) ions and DSCP bridging ligands via the addition of a poor solvent. SEM and TEM images showed that as-synthesized NCP-1 exhibited a spherical morphology with a DLS diameter of 58.3 +/- 11.3 nm. NCP-1 particles were stabilized against rapid dissolution in water by encapsulation in shells of amorphous silica. The resulting silica-coated particles NCP-1' exhibited significantly longer half-lives for DSCP release from the particles (a t sub(1/2) of similar to 9 h for NCP-1' with 7 nm silica coating vs t sub(1/2) of similar to 1 h for as-synthesized NCP-1). In vitro cancer cell cytotoxicity assays with the human colon carcinoma cell line (HT-29) showed that internalized NCP-1' particles readily released the DSCP moieties which were presumably reduced to cytotoxic Pt(II) species to give the Pt-containing NCPs anticancer efficacy superior to the cisplatin standard. The generality of this degradable nanoparticle formulation should allow for the design of NCPs as effective delivery vehicles for a variety of biologically and medically important cargoes such as therapeutic and imaging agents.
language: eng
source:
identifier: E-ISSN: 1520-5126 ; DOI: 10.1021/ja803383k
fulltext: fulltext
issn:
  • 15205126
  • 1520-5126
url: Link


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titleNanoscale coordination polymers for platinum-based anticancer drug delivery.
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identifierE-ISSN: 1520-5126 ; DOI: 10.1021/ja803383k
subjectAntineoplastic Agents–Administration & Dosage ; Cisplatin–Chemistry ; Colorectal Neoplasms–Administration & Dosage ; Delayed-Action Preparations–Analogs & Derivatives ; Drug Delivery Systems–Drug Therapy ; Ht29 Cells–Methods ; Humans–Chemistry ; Models, Molecular–Administration & Dosage ; Nanostructures–Chemistry ; Silicon Dioxide–Chemistry ; Terbium–Chemistry ; X-Ray Diffraction–Chemistry ; Antineoplastic Agents ; Delayed-Action Preparations ; Terbium ; Silicon Dioxide ; Terbium Chloride ; Cisplatin
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descriptionPt-containing nanoscale coordination polymer (NCP) particles with the formula of Tb sub(2)(DSCP) sub(3)(H sub(2)O) sub(12) (where DSCP represents disuccinatocisplatin), NCP-1, were precipitated from an aqueous solution of Tb super(3+) ions and DSCP bridging ligands via the addition of a poor solvent. SEM and TEM images showed that as-synthesized NCP-1 exhibited a spherical morphology with a DLS diameter of 58.3 +/- 11.3 nm. NCP-1 particles were stabilized against rapid dissolution in water by encapsulation in shells of amorphous silica. The resulting silica-coated particles NCP-1' exhibited significantly longer half-lives for DSCP release from the particles (a t sub(1/2) of similar to 9 h for NCP-1' with 7 nm silica coating vs t sub(1/2) of similar to 1 h for as-synthesized NCP-1). In vitro cancer cell cytotoxicity assays with the human colon carcinoma cell line (HT-29) showed that internalized NCP-1' particles readily released the DSCP moieties which were presumably reduced to cytotoxic Pt(II) species to give the Pt-containing NCPs anticancer efficacy superior to the cisplatin standard. The generality of this degradable nanoparticle formulation should allow for the design of NCPs as effective delivery vehicles for a variety of biologically and medically important cargoes such as therapeutic and imaging agents.
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