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The small intestine proteome is changed in preterm pigs developing necrotizing enterocolitis in response to formula feeding.

Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in newborn premature infants. Clinical studies show increased incidence of NEC in premature infants with enteral formula feeding; however, pathogenesis remains unclear. To identify the NEC-related proteins for molecular me... Full description

Journal Title: The Journal of nutrition October 2008, Vol.138(10), pp.1895-1901
Main Author: Jiang, Pingping
Other Authors: Siggers, Jayda Lee Ann , Ngai, Heidi Hoi-Yee , Sit, Wai-Hung , Sangild, Per T , Wan, Jennifer Man-Fan
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1541-6100
Link: http://search.proquest.com/docview/69585519/?pq-origsite=primo
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title: The small intestine proteome is changed in preterm pigs developing necrotizing enterocolitis in response to formula feeding.
format: Article
creator:
  • Jiang, Pingping
  • Siggers, Jayda Lee Ann
  • Ngai, Heidi Hoi-Yee
  • Sit, Wai-Hung
  • Sangild, Per T
  • Wan, Jennifer Man-Fan
subjects:
  • Animals–Adverse Effects
  • Enteral Nutrition–Etiology
  • Enterocolitis, Necrotizing–Adverse Effects
  • Female–Embryology
  • Infant Food–Metabolism
  • Intestine, Small–Pathology
  • Parenteral Nutrition, Total–Adverse Effects
  • Pregnancy–Adverse Effects
  • Premature Birth–Adverse Effects
  • Proteome–Adverse Effects
  • Swine–Adverse Effects
  • Proteome
ispartof: The Journal of nutrition, October 2008, Vol.138(10), pp.1895-1901
description: Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in newborn premature infants. Clinical studies show increased incidence of NEC in premature infants with enteral formula feeding; however, pathogenesis remains unclear. To identify the NEC-related proteins for molecular mechanisms, we applied proteomics analysis to characterize changes in the protein expression profile of newborn premature piglet intestines with NEC developed after enteral formula feeding for 24 h. Changes in protein expression were identified using 2-dimensional gel electrophoresis and peptide mass fingerprinting with MS as well as western blotting analysis. Nineteen differentially expressed proteins were identified and these have roles in oxidative stress, chaperone, signal transduction, protein folding and degradation, oxygen transport, signal transduction, and energy metabolism. Proteins with increased levels include manganese-containing superoxide dismutase and hemoglobin subunit and proteins with decreased expression include sorbitol dehydrogenase, mitochondrial aldehyde dehydrogenase 2, glucose-regulated protein 75, CRY protein, snail homolog 3, thyroid hormone-binding protein precursor, and DJ1 (Parkinson's disease 7) etc. The data provided novel mechanistic insights into the pathogenesis of NEC and the insults of a formulated diet to the premature gut. ; Includes references ; p. 1895-1901.
language: eng
source:
identifier: E-ISSN: 1541-6100
fulltext: fulltext
issn:
  • 15416100
  • 1541-6100
url: Link


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titleThe small intestine proteome is changed in preterm pigs developing necrotizing enterocolitis in response to formula feeding.
creatorJiang, Pingping ; Siggers, Jayda Lee Ann ; Ngai, Heidi Hoi-Yee ; Sit, Wai-Hung ; Sangild, Per T ; Wan, Jennifer Man-Fan
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subjectAnimals–Adverse Effects ; Enteral Nutrition–Etiology ; Enterocolitis, Necrotizing–Adverse Effects ; Female–Embryology ; Infant Food–Metabolism ; Intestine, Small–Pathology ; Parenteral Nutrition, Total–Adverse Effects ; Pregnancy–Adverse Effects ; Premature Birth–Adverse Effects ; Proteome–Adverse Effects ; Swine–Adverse Effects ; Proteome
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descriptionNecrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in newborn premature infants. Clinical studies show increased incidence of NEC in premature infants with enteral formula feeding; however, pathogenesis remains unclear. To identify the NEC-related proteins for molecular mechanisms, we applied proteomics analysis to characterize changes in the protein expression profile of newborn premature piglet intestines with NEC developed after enteral formula feeding for 24 h. Changes in protein expression were identified using 2-dimensional gel electrophoresis and peptide mass fingerprinting with MS as well as western blotting analysis. Nineteen differentially expressed proteins were identified and these have roles in oxidative stress, chaperone, signal transduction, protein folding and degradation, oxygen transport, signal transduction, and energy metabolism. Proteins with increased levels include manganese-containing superoxide dismutase and hemoglobin subunit and proteins with decreased expression include sorbitol dehydrogenase, mitochondrial aldehyde dehydrogenase 2, glucose-regulated protein 75, CRY protein, snail homolog 3, thyroid hormone-binding protein precursor, and DJ1 (Parkinson's disease 7) etc. The data provided novel mechanistic insights into the pathogenesis of NEC and the insults of a formulated diet to the premature gut. ; Includes references ; p. 1895-1901.
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