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Bacopasaponin C: critical evaluation of anti-leishmanial properties in various delivery modes.

max311 Bacopasaponin C, an indigenous glycoside, was isolated from Indian medicinal plant Bacopa monniera (b. brahmi) and was tested for antileishmanial properties both in free and in various delivery modes, e.g., niosomes, microspheres, and nanoparticles that are used now as alternatives to more co... Full description

Journal Title: Drug delivery 2002 Jan-Mar, Vol.9(1), pp.55-62
Main Author: Sinha, J
Other Authors: Raay, B , Das, N , Medda, S , Garai, S , Mahato, S B , Basu, M K
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1071-7544
Link: http://search.proquest.com/docview/71491300/?pq-origsite=primo
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title: Bacopasaponin C: critical evaluation of anti-leishmanial properties in various delivery modes.
format: Article
creator:
  • Sinha, J
  • Raay, B
  • Das, N
  • Medda, S
  • Garai, S
  • Mahato, S B
  • Basu, M K
subjects:
  • Animals–Administration & Dosage
  • Antiprotozoal Agents–Pharmacology
  • Cricetinae–Toxicity
  • Drug Carriers–Administration & Dosage
  • Glycosides–Pharmacology
  • In Vitro Techniques–Toxicity
  • Leishmania Donovani–Drug Effects
  • Liposomes–Drug Effects
  • Liver–Drug Effects
  • Macrophages, Peritoneal–Parasitology
  • Mesocricetus–Parasitology
  • Mice–Parasitology
  • Mice, Inbred Balb C–Parasitology
  • Spleen–Parasitology
  • Triterpenes–Parasitology
  • Antiprotozoal Agents
  • Drug Carriers
  • Glycosides
  • Liposomes
  • Triterpenes
  • Bacopasaponin C
ispartof: Drug delivery, 2002 Jan-Mar, Vol.9(1), pp.55-62
description: max311 Bacopasaponin C, an indigenous glycoside, was isolated from Indian medicinal plant Bacopa monniera (b. brahmi) and was tested for antileishmanial properties both in free and in various delivery modes, e.g., niosomes, microspheres, and nanoparticles that are used now as alternatives to more commonly used liposomes. The different vesicles were prepared by published protocols. The percent intercalation of Bacopasaponin C in liposomes, niosomes, and micropspheres determined at its absorption maximal ( max = 238 nm, = 8.6 10 3 M 1 cm 1 ) was found to be 30; for nanoparticles it was 50. At equivalent dose of 1.75 mg/kg body weight, every third day for a total of 6 doses in 15 days, Bacopasaponin C in all the vesicular forms was found to be very active. An inverse linear relationship between the efficacy and the size of the vesicles was established. As analyzed from tissue histology, blood pathology, and specific tests related to normal liver and kidney functions, Bacopasaponin C in each of the four vesicular forms was found to be without any side effects. Thus, because of its indigenous origin and non-toxic nature, Bacopasaponin C could very well be considered for application in the clinic through these alternative delivery modes.
language: eng
source:
identifier: ISSN: 1071-7544
fulltext: fulltext
issn:
  • 10717544
  • 1071-7544
url: Link


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titleBacopasaponin C: critical evaluation of anti-leishmanial properties in various delivery modes.
creatorSinha, J ; Raay, B ; Das, N ; Medda, S ; Garai, S ; Mahato, S B ; Basu, M K
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subjectAnimals–Administration & Dosage ; Antiprotozoal Agents–Pharmacology ; Cricetinae–Toxicity ; Drug Carriers–Administration & Dosage ; Glycosides–Pharmacology ; In Vitro Techniques–Toxicity ; Leishmania Donovani–Drug Effects ; Liposomes–Drug Effects ; Liver–Drug Effects ; Macrophages, Peritoneal–Parasitology ; Mesocricetus–Parasitology ; Mice–Parasitology ; Mice, Inbred Balb C–Parasitology ; Spleen–Parasitology ; Triterpenes–Parasitology ; Antiprotozoal Agents ; Drug Carriers ; Glycosides ; Liposomes ; Triterpenes ; Bacopasaponin C
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