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Microchip capillary electrophoresis with electrochemical detection.

A novel microchip capillary electrophoresis system with electrochemical detection, using the replaceable microelectrode, is first reported. This kind of electrode can be fabricated in general laboratories and can be replaced quickly with electrodes of different materials according to the requirement... Full description

Journal Title: Analytical chemistry May 15, 2002, Vol.74(10), pp.2441-2445
Main Author: Zeng, Yong
Other Authors: Chen, Hong , Pang, Dai-Wen , Wang, Zong-Li , Cheng, Jie-Ke
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0003-2700
Link: http://search.proquest.com/docview/71727674/?pq-origsite=primo
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title: Microchip capillary electrophoresis with electrochemical detection.
format: Article
creator:
  • Zeng, Yong
  • Chen, Hong
  • Pang, Dai-Wen
  • Wang, Zong-Li
  • Cheng, Jie-Ke
subjects:
  • Biogenic Amines–Analysis
  • Disposable Equipment–Analysis
  • Dopamine–Instrumentation
  • Electrochemistry–Standards
  • Electrophoresis, Capillary–Analysis
  • Epinephrine–Analysis
  • Microelectrodes–Analysis
  • Miniaturization–Analysis
  • Reproducibility of Results–Analysis
  • Sensitivity and Specificity–Analysis
  • Serotonin–Analysis
  • Biogenic Amines
  • Serotonin
  • Dopamine
  • Epinephrine
ispartof: Analytical chemistry, May 15, 2002, Vol.74(10), pp.2441-2445
description: A novel microchip capillary electrophoresis system with electrochemical detection, using the replaceable microelectrode, is first reported. This kind of electrode can be fabricated in general laboratories and can be replaced quickly with electrodes of different materials according to the requirements of experiments. The end-column electrochemical detection on microchip CE was achieved by fixing the working electrode (such as carbon fiber, Pt, or Au, etc.) through a guide robe on .the end of the separation channel. The experiment results indicate that the alignment of the electrode with the channel outlet can be carried out accurately and reproducibly, and therefore, the detection device has low noise and good reproducibility. The detection limit of dopamine is 2.4 x [10.sup.-7] M, which is the lowest result reported so far. The separation and detection of dopamine, 5-hydroxytryptamine and epinephrine using carbon fiber and Pt microdisk electrodes within 50 s was successfully performed.
language: eng
source:
identifier: ISSN: 0003-2700
fulltext: fulltext
issn:
  • 00032700
  • 0003-2700
url: Link


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titleMicrochip capillary electrophoresis with electrochemical detection.
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ispartofAnalytical chemistry, May 15, 2002, Vol.74(10), pp.2441-2445
identifierISSN: 0003-2700
subjectBiogenic Amines–Analysis ; Disposable Equipment–Analysis ; Dopamine–Instrumentation ; Electrochemistry–Standards ; Electrophoresis, Capillary–Analysis ; Epinephrine–Analysis ; Microelectrodes–Analysis ; Miniaturization–Analysis ; Reproducibility of Results–Analysis ; Sensitivity and Specificity–Analysis ; Serotonin–Analysis ; Biogenic Amines ; Serotonin ; Dopamine ; Epinephrine
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descriptionA novel microchip capillary electrophoresis system with electrochemical detection, using the replaceable microelectrode, is first reported. This kind of electrode can be fabricated in general laboratories and can be replaced quickly with electrodes of different materials according to the requirements of experiments. The end-column electrochemical detection on microchip CE was achieved by fixing the working electrode (such as carbon fiber, Pt, or Au, etc.) through a guide robe on .the end of the separation channel. The experiment results indicate that the alignment of the electrode with the channel outlet can be carried out accurately and reproducibly, and therefore, the detection device has low noise and good reproducibility. The detection limit of dopamine is 2.4 x [10.sup.-7] M, which is the lowest result reported so far. The separation and detection of dopamine, 5-hydroxytryptamine and epinephrine using carbon fiber and Pt microdisk electrodes within 50 s was successfully performed.
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