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An investigation of the cytotoxicity and histocompatibility of in situ forming lactic acid based orthopedic biomaterials.

The cytotoxicity and biocompatibility of polymer networks prefabricated from multifunctional lactic acid based oligomers that are being developed for orthopedic applications were assessed through in vitro cytotoxicity analysis and subcutaneous implantation. After 7 and 14 days, no significant differ... Full description

Journal Title: Journal of biomedical materials research 2002, Vol.63(5), pp.484-491
Main Author: Burdick, Jason A
Other Authors: Padera, Robert F , Huang, Janice V , Anseth, Kristi S
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0021-9304
Link: http://search.proquest.com/docview/72056065/?pq-origsite=primo
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title: An investigation of the cytotoxicity and histocompatibility of in situ forming lactic acid based orthopedic biomaterials.
format: Article
creator:
  • Burdick, Jason A
  • Padera, Robert F
  • Huang, Janice V
  • Anseth, Kristi S
subjects:
  • Alkaline Phosphatase–Metabolism
  • Animals–Metabolism
  • Biocompatible Materials–Toxicity
  • Cell Survival–Metabolism
  • Cells, Cultured–Physiology
  • Lactic Acid–Chemistry
  • Molecular Structure–Metabolism
  • Osteoblasts–Toxicity
  • Polymers–Cytology
  • Prostheses and Implants–Anatomy & Histology
  • Rats–Metabolism
  • Rats, Sprague-Dawley–Metabolism
  • Skull–Metabolism
  • Subcutaneous Tissue–Metabolism
  • Biocompatible Materials
  • Polymers
  • Lactic Acid
  • Alkaline Phosphatase
ispartof: Journal of biomedical materials research, 2002, Vol.63(5), pp.484-491
description: The cytotoxicity and biocompatibility of polymer networks prefabricated from multifunctional lactic acid based oligomers that are being developed for orthopedic applications were assessed through in vitro cytotoxicity analysis and subcutaneous implantation. After 7 and 14 days, no significant difference was observed in the relative viability or alkaline phosphatase activity of primary rat calvarial osteoblasts cultured in the presence or absence of degrading polymer networks, indicating that the degradation products had no detrimental effect on the function or activity of the cultured cells. The tissue response to preformed lactic acid networks implanted in rats consisted of a mild inflammatory response with an increase in fibrous capsule thickness and inflammation correlating with faster degrading polymer compositions. This relatively neutral response is indicative of a biocompatible, degradable polymer that has potential medical applications. Finally, porous scaffolds were implanted subcutaneously...
language: eng
source:
identifier: ISSN: 0021-9304
fulltext: fulltext
issn:
  • 00219304
  • 0021-9304
url: Link


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titleAn investigation of the cytotoxicity and histocompatibility of in situ forming lactic acid based orthopedic biomaterials.
creatorBurdick, Jason A ; Padera, Robert F ; Huang, Janice V ; Anseth, Kristi S
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ispartofJournal of biomedical materials research, 2002, Vol.63(5), pp.484-491
identifierISSN: 0021-9304
subjectAlkaline Phosphatase–Metabolism ; Animals–Metabolism ; Biocompatible Materials–Toxicity ; Cell Survival–Metabolism ; Cells, Cultured–Physiology ; Lactic Acid–Chemistry ; Molecular Structure–Metabolism ; Osteoblasts–Toxicity ; Polymers–Cytology ; Prostheses and Implants–Anatomy & Histology ; Rats–Metabolism ; Rats, Sprague-Dawley–Metabolism ; Skull–Metabolism ; Subcutaneous Tissue–Metabolism ; Biocompatible Materials ; Polymers ; Lactic Acid ; Alkaline Phosphatase
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descriptionThe cytotoxicity and biocompatibility of polymer networks prefabricated from multifunctional lactic acid based oligomers that are being developed for orthopedic applications were assessed through in vitro cytotoxicity analysis and subcutaneous implantation. After 7 and 14 days, no significant difference was observed in the relative viability or alkaline phosphatase activity of primary rat calvarial osteoblasts cultured in the presence or absence of degrading polymer networks, indicating that the degradation products had no detrimental effect on the function or activity of the cultured cells. The tissue response to preformed lactic acid networks implanted in rats consisted of a mild inflammatory response with an increase in fibrous capsule thickness and inflammation correlating with faster degrading polymer compositions. This relatively neutral response is indicative of a biocompatible, degradable polymer that has potential medical applications. Finally, porous scaffolds were implanted subcutaneously...
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