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Computational model of steroidogenesis in human H295R cells to predict biochemical response to endocrine-active chemicals: model development for metyrapone.

BACKGROUNDAn in vitro steroidogenesis assay using the human adrenocortical carcinoma cell line H295R is being evaluated as a possible screening assay to detect and assess the impact of endocrine-active chemicals (EACs) capable of altering steroid biosynthesis. Data interpretation and their quantitat... Full description

Journal Title: Environmental health perspectives February 2010, Vol.118(2), pp.265-272
Main Author: Breen, Michael S
Other Authors: Breen, Miyuki , Terasaki, Natsuko , Yamazaki, Makoto , Conolly, Rory B
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1552-9924 ; DOI: 10.1289/ehp.0901107
Link: http://search.proquest.com/docview/733146607/?pq-origsite=primo
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recordid: proquest733146607
title: Computational model of steroidogenesis in human H295R cells to predict biochemical response to endocrine-active chemicals: model development for metyrapone.
format: Article
creator:
  • Breen, Michael S
  • Breen, Miyuki
  • Terasaki, Natsuko
  • Yamazaki, Makoto
  • Conolly, Rory B
subjects:
  • Adrenal Glands–Drug Effects
  • Cell Line, Tumor–Metabolism
  • Computational Biology–Methods
  • Endocrine Disruptors–Pharmacology
  • Humans–Pharmacology
  • Metyrapone–Metabolism
  • Models, Theoretical–Metabolism
  • Steroids–Metabolism
  • Endocrine Disruptors
  • Steroids
  • Metyrapone
ispartof: Environmental health perspectives, February 2010, Vol.118(2), pp.265-272
description: BACKGROUNDAn in vitro steroidogenesis assay using the human adrenocortical carcinoma cell line H295R is being evaluated as a possible screening assay to detect and assess the impact of endocrine-active chemicals (EACs) capable of altering steroid biosynthesis. Data interpretation and their quantitative...
language: eng
source:
identifier: E-ISSN: 1552-9924 ; DOI: 10.1289/ehp.0901107
fulltext: fulltext
issn:
  • 15529924
  • 1552-9924
url: Link


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titleComputational model of steroidogenesis in human H295R cells to predict biochemical response to endocrine-active chemicals: model development for metyrapone.
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identifierE-ISSN: 1552-9924 ; DOI: 10.1289/ehp.0901107
subjectAdrenal Glands–Drug Effects ; Cell Line, Tumor–Metabolism ; Computational Biology–Methods ; Endocrine Disruptors–Pharmacology ; Humans–Pharmacology ; Metyrapone–Metabolism ; Models, Theoretical–Metabolism ; Steroids–Metabolism ; Endocrine Disruptors ; Steroids ; Metyrapone
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abstractBACKGROUNDAn in vitro steroidogenesis assay using the human adrenocortical carcinoma cell line H295R is being evaluated as a possible screening assay to detect and assess the impact of endocrine-active chemicals (EACs) capable of altering steroid biosynthesis. Data interpretation and their quantitative...
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date2010-02-01