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White matter abnormalities in first-episode schizophrenia: a combined structural MRI and DTI study.

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.schres.2009.12.012 Byline: Wai-Yen Chan (a), Guo-Liang Yang (b), Ming-Ying Chia (a), Ik-Yung Lau (c), Yih-Yian Sitoh (d), Wieslaw Lucjan Nowinski (b), Kang Sim (a)(e) Keywords: Schizophrenia; First-episode; Di... Full description

Journal Title: Schizophrenia research June 2010, Vol.119(1-3), pp.52-60
Main Author: Chan, Wai-Yen
Other Authors: Yang, Guo-Liang , Chia, Ming-Ying , Lau, Ik-Yung , Sitoh, Yih-Yian , Nowinski, Wieslaw Lucjan , Sim, Kang
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1573-2509 ; DOI: 10.1016/j.schres.2009.12.012
Link: http://search.proquest.com/docview/733444815/?pq-origsite=primo
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title: White matter abnormalities in first-episode schizophrenia: a combined structural MRI and DTI study.
format: Article
creator:
  • Chan, Wai-Yen
  • Yang, Guo-Liang
  • Chia, Ming-Ying
  • Lau, Ik-Yung
  • Sitoh, Yih-Yian
  • Nowinski, Wieslaw Lucjan
  • Sim, Kang
subjects:
  • Adult–Pathology
  • Brain Mapping–Pathology
  • Diffusion Magnetic Resonance Imaging–Pathology
  • Female–Diagnosis
  • Humans–Pathology
  • Image Processing, Computer-Assisted–Pathology
  • Magnetic Resonance Imaging–Pathology
  • Male–Pathology
  • Nerve Fibers, Myelinated–Pathology
  • Neural Pathways–Pathology
  • Occipital Lobe–Pathology
  • Reference Values–Pathology
  • Schizophrenia–Pathology
  • Temporal Lobe–Pathology
  • Young Adult–Pathology
ispartof: Schizophrenia research, June 2010, Vol.119(1-3), pp.52-60
description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.schres.2009.12.012 Byline: Wai-Yen Chan (a), Guo-Liang Yang (b), Ming-Ying Chia (a), Ik-Yung Lau (c), Yih-Yian Sitoh (d), Wieslaw Lucjan Nowinski (b), Kang Sim (a)(e) Keywords: Schizophrenia; First-episode; Diffusion tensor imaging; Geometric indices; Fractional anisotropy; Inferior longitudinal fasciculus Abstract: This study examined white matter volume change and integrity jointly in patients with first-episode schizophrenia using an empirically derived region of interest approach and novel Diffusion Tensor Imaging (DTI) geometric indices. Structural images from 103 individuals comprising of 39 patients with first-episode schizophrenia and 64 healthy controls were examined for regions of white matter volume change using voxel-based morphometry (VBM). These regions were then further interrogated for group differences employing geometric indices in addition to fractional anisotropy (FA).VBM analyses revealed that patients with first-episode schizophrenia had lower white matter volume in the right temporal-occipital region (p
language: eng
source:
identifier: E-ISSN: 1573-2509 ; DOI: 10.1016/j.schres.2009.12.012
fulltext: fulltext
issn:
  • 15732509
  • 1573-2509
url: Link


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titleWhite matter abnormalities in first-episode schizophrenia: a combined structural MRI and DTI study.
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identifierE-ISSN: 1573-2509 ; DOI: 10.1016/j.schres.2009.12.012
subjectAdult–Pathology ; Brain Mapping–Pathology ; Diffusion Magnetic Resonance Imaging–Pathology ; Female–Diagnosis ; Humans–Pathology ; Image Processing, Computer-Assisted–Pathology ; Magnetic Resonance Imaging–Pathology ; Male–Pathology ; Nerve Fibers, Myelinated–Pathology ; Neural Pathways–Pathology ; Occipital Lobe–Pathology ; Reference Values–Pathology ; Schizophrenia–Pathology ; Temporal Lobe–Pathology ; Young Adult–Pathology
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descriptionTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.schres.2009.12.012 Byline: Wai-Yen Chan (a), Guo-Liang Yang (b), Ming-Ying Chia (a), Ik-Yung Lau (c), Yih-Yian Sitoh (d), Wieslaw Lucjan Nowinski (b), Kang Sim (a)(e) Keywords: Schizophrenia; First-episode; Diffusion tensor imaging; Geometric indices; Fractional anisotropy; Inferior longitudinal fasciculus Abstract: This study examined white matter volume change and integrity jointly in patients with first-episode schizophrenia using an empirically derived region of interest approach and novel Diffusion Tensor Imaging (DTI) geometric indices. Structural images from 103 individuals comprising of 39 patients with first-episode schizophrenia and 64 healthy controls were examined for regions of white matter volume change using voxel-based morphometry (VBM). These regions were then further interrogated for group differences employing geometric indices in addition to fractional anisotropy (FA).VBM analyses revealed that patients with first-episode schizophrenia had lower white matter volume in the right temporal-occipital region (p <0.005) corresponding to the inferior longitudinal fasciculus. Further analyses of diffusion anisotropy in the right temporal-occipital region revealed lower planar anisotropy, and higher linear anisotropy (p =0.012) in patients. FA in the implicated region was also found to be correlated with severity of delusions (r =0.47, p =0.004).We confirmed previous findings of lower white matter volume in the region of inferior longitudinal fasciculus. The presence of changes in geometric diffusion indices in the implicated white matter region suggested that pathophysiological processes which underlie cerebral white matter volume reduction may not be reflected by changes in FA. Further research is needed to better understand the nature of these white matter changes and its progression in schizophrenia over time. Author Affiliation: (a) Research Division, Institute of Mental Health, Singapore (b) Biomedical Imaging Laboratory, Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore (c) Health Products Regulation Group, Health Sciences Authority, Singapore (d) Department of Neuroradiology, National Neuroscience Institute, Singapore (e) Department of General Psychiatry, Institute of Mental Health, Singapore, 10, Buangkok View, 539747, Singapore Article History: Received 22 June 2009; Revised 25 November 2009; Accepted 14 December 2009
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titleWhite matter abnormalities in first-episode schizophrenia: a combined structural MRI and DTI study.
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