schliessen

Filtern

 

Bibliotheken

Social networks shape the transmission dynamics of hepatitis C virus.

Hepatitis C virus (HCV) infects 170 million people worldwide, and is a major public health problem in Brazil, where over 1% of the population may be infected and where multiple viral genotypes co-circulate. Chronically infected individuals are both the source of transmission to others and are at ris... Full description

Journal Title: PloS one June 23, 2010, Vol.5(6), p.e11170
Main Author: Romano, Camila Malta
Other Authors: de Carvalho-Mello, Isabel M V Guedes , Jamal, Leda F , de Melo, Fernando Lucas , Iamarino, Atila , Motoki, Marco , Pinho, João Renato Rebello , Holmes, Edward C , de Andrade Zanotto, Paolo Marinho , Romano, Camila Malta
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0011170
Link: http://search.proquest.com/docview/733501063/?pq-origsite=primo
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: proquest733501063
title: Social networks shape the transmission dynamics of hepatitis C virus.
format: Article
creator:
  • Romano, Camila Malta
  • de Carvalho-Mello, Isabel M V Guedes
  • Jamal, Leda F
  • de Melo, Fernando Lucas
  • Iamarino, Atila
  • Motoki, Marco
  • Pinho, João Renato Rebello
  • Holmes, Edward C
  • de Andrade Zanotto, Paolo Marinho
  • Romano, Camila Malta
subjects:
  • Hepatitis C–Classification
  • Humans–Transmission
  • Phylogeny–Transmission
  • Social Support–Transmission
ispartof: PloS one, June 23, 2010, Vol.5(6), p.e11170
description: Hepatitis C virus (HCV) infects 170 million people worldwide, and is a major public health problem in Brazil, where over 1% of the population may be infected and where multiple viral genotypes co-circulate. Chronically infected individuals are both the source of transmission to others and are at risk for HCV-related diseases, such as liver cancer and cirrhosis. Before the adoption of anti-HCV control measures in blood banks, this virus was mainly transmitted via blood transfusion. Today, needle sharing among injecting drug users is the most common form of HCV transmission. Of particular importance is that HCV prevalence is growing in non-risk groups. Since there is no vaccine against HCV, it is important to determine the factors that control viral transmission in order to develop more efficient control measures. However, despite the health costs associated with HCV, the factors that determine the spread of virus at the epidemiological scale are often poorly understood. Here, we sequenced partial NS5b gene sequences sampled from blood samples collected from 591 patients in S#227;o Paulo state, Brazil. We show that different viral genotypes entered S#227;o Paulo at different times, grew at different rates, and are associated with different age groups and risk behaviors. In particular, subtype 1b is older and grew more slowly than subtypes 1a and 3a, and is associated with multiple age classes. In contrast, subtypes 1a and 3b are associated with younger people infected more recently, possibly with higher rates of sexual transmission. The transmission dynamics of HCV in S#227;o Paulo therefore vary by subtype and are determined by a combination of age, risk exposure and underlying social network. We conclude that social factors may play a key role in determining the rate and pattern of HCV spread, and should influence future intervention policies.
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0011170
fulltext: fulltext
issn:
  • 19326203
  • 1932-6203
url: Link


@attributes
ID798421353
RANK0.06999999
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid733501063
sourceidproquest
recordidTN_proquest733501063
sourcesystemPC
pqid733501063
galeid473889148
display
typearticle
titleSocial networks shape the transmission dynamics of hepatitis C virus.
creatorRomano, Camila Malta ; de Carvalho-Mello, Isabel M V Guedes ; Jamal, Leda F ; de Melo, Fernando Lucas ; Iamarino, Atila ; Motoki, Marco ; Pinho, João Renato Rebello ; Holmes, Edward C ; de Andrade Zanotto, Paolo Marinho ; Romano, Camila Malta
contributorTateno, Adriana (correspondence author) ; Duarte, Alberto José Da Silva (record owner) ; Martinelli, Ana Luiza ; Pannuti, Cláudio Sérgio ; de Lima, Edimo Garcia ; Durigon, Edison Luiz ; Massad, Eduardo ; Malta, Fernanda de Mello ; Gonçales Júnior, Fernando Lopes ; Carrilho, Flair José ; Lopes, Gabriela Peçanha ; de Araújo, Jansen ; Levi, José Eduardo ; Garcia, José Fernando ; Wolff, José Luiz Caldas ; Candeias, João Manuel Grisi ; Richtzenhain, Leonardo José ; Pardini, Maria Inês de Moura Campos ; Da Silva, Mariliza Henrique ; Nogueira, Maurício ; Gomes-Gouvêa, Michele Mesquita ; Ueda, Mirthes ; Yamaguchi, Mônica ; Rahal, Paula ; Han, Sang Won ; Notaroberto, Suzete ; de Magalhães, Vanda Dolabela ; Botosso, Viviane ; Bloch, Juliana Aliano ; Rezende, Rosamar E F ; Rezende, Rosamar E F ; Rezende, Rosamar E F
ispartofPloS one, June 23, 2010, Vol.5(6), p.e11170
identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0011170
subjectHepatitis C–Classification ; Humans–Transmission ; Phylogeny–Transmission ; Social Support–Transmission
languageeng
source
descriptionHepatitis C virus (HCV) infects 170 million people worldwide, and is a major public health problem in Brazil, where over 1% of the population may be infected and where multiple viral genotypes co-circulate. Chronically infected individuals are both the source of transmission to others and are at risk for HCV-related diseases, such as liver cancer and cirrhosis. Before the adoption of anti-HCV control measures in blood banks, this virus was mainly transmitted via blood transfusion. Today, needle sharing among injecting drug users is the most common form of HCV transmission. Of particular importance is that HCV prevalence is growing in non-risk groups. Since there is no vaccine against HCV, it is important to determine the factors that control viral transmission in order to develop more efficient control measures. However, despite the health costs associated with HCV, the factors that determine the spread of virus at the epidemiological scale are often poorly understood. Here, we sequenced partial NS5b gene sequences sampled from blood samples collected from 591 patients in S#227;o Paulo state, Brazil. We show that different viral genotypes entered S#227;o Paulo at different times, grew at different rates, and are associated with different age groups and risk behaviors. In particular, subtype 1b is older and grew more slowly than subtypes 1a and 3a, and is associated with multiple age classes. In contrast, subtypes 1a and 3b are associated with younger people infected more recently, possibly with higher rates of sexual transmission. The transmission dynamics of HCV in S#227;o Paulo therefore vary by subtype and are determined by a combination of age, risk exposure and underlying social network. We conclude that social factors may play a key role in determining the rate and pattern of HCV spread, and should influence future intervention policies.
version10
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://search.proquest.com/docview/733501063/?pq-origsite=primo$$EView_record_in_ProQuest_(subscribers_only)
search
creatorcontrib
0Romano, Camila Malta
1de Carvalho-Mello, Isabel M V Guedes
2Jamal, Leda F
3de Melo, Fernando Lucas
4Iamarino, Atila
5Motoki, Marco
6Pinho, João Renato Rebello
7Holmes, Edward C
8de Andrade Zanotto, Paolo Marinho
titleSocial networks shape the transmission dynamics of hepatitis C virus.
subject
0Hepatitis C–Classification
1Humans–Transmission
2Phylogeny–Transmission
3Social Support–Transmission
general
0English
110.1371/journal.pone.0011170
2MEDLINE (ProQuest)
3ProQuest Biological Science Collection
4ProQuest Natural Science Collection
5ProQuest SciTech Collection
6Biological Science Database
7Natural Science Collection
8SciTech Premium Collection
9Health Research Premium Collection
10Health Research Premium Collection (Alumni edition)
11Biological Science Index (ProQuest)
sourceidproquest
recordidproquest733501063
issn
019326203
11932-6203
rsrctypearticle
creationdate2010
addtitlePloS one
searchscope
01007527
11007944
21009130
310000004
410000038
510000050
610000120
710000159
810000238
910000253
1010000260
1110000270
1210000271
1310000302
1410000350
15proquest
scope
01007527
11007944
21009130
310000004
410000038
510000050
610000120
710000159
810000238
910000253
1010000260
1110000270
1210000271
1310000302
1410000350
15proquest
lsr43
01007527false
11007944false
21009130false
310000004false
410000038false
510000050false
610000120false
710000159false
810000238false
910000253false
1010000260false
1110000270false
1210000271false
1310000302false
1410000350false
contributor
0Tateno, Adriana
1Duarte, Alberto José Da Silva
2Martinelli, Ana Luiza
3Pannuti, Cláudio Sérgio
4de Lima, Edimo Garcia
5Durigon, Edison Luiz
6Massad, Eduardo
7Malta, Fernanda de Mello
8Gonçales Júnior, Fernando Lopes
9Carrilho, Flair José
10Lopes, Gabriela Peçanha
11de Araújo, Jansen
12Levi, José Eduardo
13Garcia, José Fernando
14Wolff, José Luiz Caldas
15Candeias, João Manuel Grisi
16Richtzenhain, Leonardo José
17Pardini, Maria Inês de Moura Campos
18Da Silva, Mariliza Henrique
19Nogueira, Maurício
20Gomes-Gouvêa, Michele Mesquita
21Ueda, Mirthes
22Yamaguchi, Mônica
23Rahal, Paula
24Han, Sang Won
25Notaroberto, Suzete
26de Magalhães, Vanda Dolabela
27Botosso, Viviane
28Bloch, Juliana Aliano
29Rezende, Rosamar E F
startdate20100623
enddate20100623
citationpf e11170 pt e11170 vol 5 issue 6
lsr30VSR-Enriched:[galeid, description, pqid]
sort
titleSocial networks shape the transmission dynamics of hepatitis C virus.
authorRomano, Camila Malta ; de Carvalho-Mello, Isabel M V Guedes ; Jamal, Leda F ; de Melo, Fernando Lucas ; Iamarino, Atila ; Motoki, Marco ; Pinho, João Renato Rebello ; Holmes, Edward C ; de Andrade Zanotto, Paolo Marinho ; Romano, Camila Malta
creationdate20100623
lso0120100623
facets
frbrgroupid6071743048350493967
frbrtype5
newrecords20181218
languageeng
creationdate2010
topic
0Hepatitis C–Classification
1Humans–Transmission
2Phylogeny–Transmission
3Social Support–Transmission
collection
0MEDLINE (ProQuest)
1ProQuest Biological Science Collection
2ProQuest Natural Science Collection
3ProQuest SciTech Collection
4Biological Science Database
5Natural Science Collection
6SciTech Premium Collection
7Health Research Premium Collection
8Health Research Premium Collection (Alumni edition)
9Biological Science Index (ProQuest)
prefilterarticles
rsrctypearticles
creatorcontrib
0Romano, Camila Malta
1de Carvalho-Mello, Isabel M V Guedes
2Jamal, Leda F
3de Melo, Fernando Lucas
4Iamarino, Atila
5Motoki, Marco
6Pinho, João Renato Rebello
7Holmes, Edward C
8de Andrade Zanotto, Paolo Marinho
9Tateno, Adriana
10Duarte, Alberto José Da Silva
11Martinelli, Ana Luiza
12Pannuti, Cláudio Sérgio
13de Lima, Edimo Garcia
14Durigon, Edison Luiz
15Massad, Eduardo
16Malta, Fernanda de Mello
17Gonçales Júnior, Fernando Lopes
18Carrilho, Flair José
19Lopes, Gabriela Peçanha
20de Araújo, Jansen
21Levi, José Eduardo
22Garcia, José Fernando
23Wolff, José Luiz Caldas
24Candeias, João Manuel Grisi
25Richtzenhain, Leonardo José
26Pardini, Maria Inês de Moura Campos
27Da Silva, Mariliza Henrique
28Nogueira, Maurício
29Gomes-Gouvêa, Michele Mesquita
30Ueda, Mirthes
31Yamaguchi, Mônica
32Rahal, Paula
33Han, Sang Won
34Notaroberto, Suzete
35de Magalhães, Vanda Dolabela
36Botosso, Viviane
37Bloch, Juliana Aliano
38Rezende, Rosamar E F
jtitlePloS one
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Romano
1de Carvalho-Mello
2Jamal
3de Melo
4Iamarino
5Motoki
6Pinho
7Holmes
8de Andrade Zanotto
aufirst
0Camila Malta
1Isabel M V Guedes
2Leda F
3Fernando Lucas
4Atila
5Marco
6João Renato Rebello
7Edward C
8Paolo Marinho
au
0Romano, Camila Malta
1de Carvalho-Mello, Isabel M V Guedes
2Jamal, Leda F
3de Melo, Fernando Lucas
4Iamarino, Atila
5Motoki, Marco
6Pinho, João Renato Rebello
7Holmes, Edward C
8de Andrade Zanotto, Paolo Marinho
addau
0Tateno, Adriana
1Duarte, Alberto José da Silva
2Martinelli, Ana Luiza
3Pannuti, Cláudio Sérgio
4de Lima, Edimo Garcia
5Durigon, Edison Luiz
6Massad, Eduardo
7Malta, Fernanda de Mello
8Gonçales Júnior, Fernando Lopes
9Carrilho, Flair José
10Lopes, Gabriela Peçanha
11de Araújo, Jansen
12Levi, José Eduardo
13Garcia, José Fernando
14Wolff, José Luiz Caldas
15Candeias, João Manuel Grisi
16Richtzenhain, Leonardo José
17Pardini, Maria Inês de Moura Campos
18da Silva, Mariliza Henrique
19Nogueira, Maurício
20Gomes-Gouvêa, Michele Mesquita
21Ueda, Mirthes
22Yamaguchi, Mônica
23Rahal, Paula
24Han, Sang Won
25Notaroberto, Suzete
26de Magalhães, Vanda Dolabela
27Botosso, Viviane
28Bloch, Juliana Aliano
29Rezende, Rosamar E F
atitleSocial networks shape the transmission dynamics of hepatitis C virus.
jtitlePloS one
risdate20100623
volume5
issue6
spagee11170
epagee11170
pagese11170
eissn1932-6203
formatjournal
genrearticle
ristypeJOUR
doi10.1371/journal.pone.0011170
urlhttp://search.proquest.com/docview/733501063/
date2010-06-23