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Longitudinal associations of blood markers of insulin and glucose metabolism and cancer mortality in the third National Health and Nutrition Examination Survey.

Insulin and glucose may influence cancer mortality via their proliferative and anti-apoptotic properties. Using longitudinal data from the nationally representative Third National Health and Nutrition Examination Survey (NHANES III; 1988-1994), with an average follow-up of 8.5 years to death, we eva... Full description

Journal Title: Cancer causes & control : CCC April 2010, Vol.21(4), pp.631-642
Main Author: Parekh, Niyati
Other Authors: Lin, Yong , Hayes, Richard B , Albu, Jeanine B , Lu-Yao, Grace L
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1573-7225 ; DOI: 10.1007/s10552-009-9492-y
Link: http://search.proquest.com/docview/733713045/?pq-origsite=primo
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recordid: proquest733713045
title: Longitudinal associations of blood markers of insulin and glucose metabolism and cancer mortality in the third National Health and Nutrition Examination Survey.
format: Article
creator:
  • Parekh, Niyati
  • Lin, Yong
  • Hayes, Richard B
  • Albu, Jeanine B
  • Lu-Yao, Grace L
subjects:
  • Adult–Blood
  • Aged–Metabolism
  • Aged, 80 and Over–Blood
  • Biomarkers–Metabolism
  • Blood Glucose–Blood
  • Body Mass Index–Metabolism
  • C-Peptide–Blood
  • Female–Blood
  • Glucose–Metabolism
  • Health Surveys–Mortality
  • Humans–Mortality
  • Insulin–Mortality
  • Insulin Resistance–Mortality
  • Life Style–Mortality
  • Lipids–Mortality
  • Longitudinal Studies–Mortality
  • Male–Mortality
  • Middle Aged–Mortality
  • Neoplasms–Mortality
  • Nutrition Surveys
ispartof: Cancer causes & control : CCC, April 2010, Vol.21(4), pp.631-642
description: Insulin and glucose may influence cancer mortality via their proliferative and anti-apoptotic properties. Using longitudinal data from the nationally representative Third National Health and Nutrition Examination Survey (NHANES III; 1988-1994), with an average follow-up of 8.5 years to death, we evaluated markers of glucose and insulin metabolism, with cancer mortality, ascertained using death certificates or the National Death Index. Plasma glucose, insulin, C-peptide, and lipid concentrations were measured. Anthropometrics, lifestyle, medical, and demographic information was obtained during in-person interviews. After adjusting for age, race, sex, smoking status, physical activity, and body mass index, for every 50 mg/dl increase in plasma glucose, there was a 22% increased risk of overall cancer mortality. Insulin resistance was associated with a 41% (95% confidence interval (CI) (1.07-1.87; p = 0.01) increased risk of overall cancer mortality. These associations were stronger after excluding lung cancer deaths for insulin-resistant individuals (HR: 1.67; 95% CI: 1.15-2.42; p = 0.01), specifically among those with lower levels of physical activity (HR: 2.06; 95% CI: 1.4-3.0; p = 0.0001). Similar associations were observed for other blood markers of glucose and insulin, albeit not statistically significant. In conclusion, hyperglycemia and insulin resistance may be 'high-risk' conditions for cancer mortality. Managing these conditions may be effective cancer control tools.
language: eng
source:
identifier: E-ISSN: 1573-7225 ; DOI: 10.1007/s10552-009-9492-y
fulltext: fulltext
issn:
  • 15737225
  • 1573-7225
url: Link


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titleLongitudinal associations of blood markers of insulin and glucose metabolism and cancer mortality in the third National Health and Nutrition Examination Survey.
creatorParekh, Niyati ; Lin, Yong ; Hayes, Richard B ; Albu, Jeanine B ; Lu-Yao, Grace L
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identifierE-ISSN: 1573-7225 ; DOI: 10.1007/s10552-009-9492-y
subjectAdult–Blood ; Aged–Metabolism ; Aged, 80 and Over–Blood ; Biomarkers–Metabolism ; Blood Glucose–Blood ; Body Mass Index–Metabolism ; C-Peptide–Blood ; Female–Blood ; Glucose–Metabolism ; Health Surveys–Mortality ; Humans–Mortality ; Insulin–Mortality ; Insulin Resistance–Mortality ; Life Style–Mortality ; Lipids–Mortality ; Longitudinal Studies–Mortality ; Male–Mortality ; Middle Aged–Mortality ; Neoplasms–Mortality ; Nutrition Surveys
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descriptionInsulin and glucose may influence cancer mortality via their proliferative and anti-apoptotic properties. Using longitudinal data from the nationally representative Third National Health and Nutrition Examination Survey (NHANES III; 1988-1994), with an average follow-up of 8.5 years to death, we evaluated markers of glucose and insulin metabolism, with cancer mortality, ascertained using death certificates or the National Death Index. Plasma glucose, insulin, C-peptide, and lipid concentrations were measured. Anthropometrics, lifestyle, medical, and demographic information was obtained during in-person interviews. After adjusting for age, race, sex, smoking status, physical activity, and body mass index, for every 50 mg/dl increase in plasma glucose, there was a 22% increased risk of overall cancer mortality. Insulin resistance was associated with a 41% (95% confidence interval (CI) (1.07-1.87; p = 0.01) increased risk of overall cancer mortality. These associations were stronger after excluding lung cancer deaths for insulin-resistant individuals (HR: 1.67; 95% CI: 1.15-2.42; p = 0.01), specifically among those with lower levels of physical activity (HR: 2.06; 95% CI: 1.4-3.0; p = 0.0001). Similar associations were observed for other blood markers of glucose and insulin, albeit not statistically significant. In conclusion, hyperglycemia and insulin resistance may be 'high-risk' conditions for cancer mortality. Managing these conditions may be effective cancer control tools.
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