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Intake of trans fatty acids and risk of coronary heart disease among women.

Trans isomers of fatty acids, formed by the partial hydrogenation of vegetable oils to produce margarine and vegetable shortening, increase the ratio of plasma low-density-lipoprotein to high-density-lipoprotein cholesterol, so it is possible that they adversely influence risk of coronary heart dise... Full description

Journal Title: Lancet (London England), March 6, 1993, Vol.341(8845), pp.581-585
Main Author: Willett, W C
Other Authors: Stampfer, M J , Manson, J E , Colditz, G A , Speizer, F E , Rosner, B A , Sampson, L A , Hennekens, C H
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0140-6736
Link: http://search.proquest.com/docview/75585475/?pq-origsite=primo
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recordid: proquest75585475
title: Intake of trans fatty acids and risk of coronary heart disease among women.
format: Article
creator:
  • Willett, W C
  • Stampfer, M J
  • Manson, J E
  • Colditz, G A
  • Speizer, F E
  • Rosner, B A
  • Sampson, L A
  • Hennekens, C H
subjects:
  • Age Factors–Blood
  • Body Mass Index–Blood
  • Cholesterol, HDL–Blood
  • Cholesterol, LDL–Epidemiology
  • Cohort Studies–Etiology
  • Coronary Disease–Adverse Effects
  • Diet Surveys–Analysis
  • Energy Intake–Chemistry
  • Energy Metabolism–Complications
  • Exercise–Adverse Effects
  • Fatty Acids, Unsaturated–Analysis
  • Female–Adverse Effects
  • Humans–Epidemiology
  • Hydrogenation–Therapeutic Use
  • Hypertension–Therapeutic Use
  • Margarine–Therapeutic Use
  • Nurses–Therapeutic Use
  • Proportional Hazards Models–Therapeutic Use
  • Risk Factors–Therapeutic Use
  • Smoking–Therapeutic Use
  • Stereoisomerism–Therapeutic Use
  • United States–Therapeutic Use
  • Vitamins–Therapeutic Use
  • Abridged
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Fatty Acids, Unsaturated
  • Vitamins
  • Margarine
ispartof: Lancet (London, England), March 6, 1993, Vol.341(8845), pp.581-585
description: Trans isomers of fatty acids, formed by the partial hydrogenation of vegetable oils to produce margarine and vegetable shortening, increase the ratio of plasma low-density-lipoprotein to high-density-lipoprotein cholesterol, so it is possible that they adversely influence risk of coronary heart disease (CHD). To investigate this possibility, we studied dietary data from participants in the Nurses' Health Study. We calculated intake of trans fatty acids from dietary questionnaires completed by 85 095 women without diagnosed CHD, stroke, diabetes, or hypercholesterolaemia in 1980. During 8 years of follow-up, there were 431 cases of new CHD (non-fatal myocardial infarction or death from CHD). After adjustment for age and total energy intake, intake of trans isomers was directly related to risk of CHD (relative risk for highest vs lowest quintile 1.50 [95% Cl 1.12-2.00], p for trend = 00.001). Additional control for established CHD risk factors, multivitamin use, and intakes of saturated fat, monounsaturated fat, and linoleic acid, dietary cholesterol, vitamins E or C, carotene, or fibre did not change the relative risk substantially. The association was stronger for the 69 181 women whose margarine consumption over the previous 10 years had been stable (1.67 [1.05-2.66], p for trend=0.002). Intakes of foods that are major sources of trans isomers (margarine, cookies [biscuits], cake, and white bread) were each significantly associated with higher risks of CHD. These findings support the hypothesis that consumption of partially hydrogenated vegetable oils may contribute to occurrence of CHD. Lancet 1993; 341: 581-85.
language: eng
source:
identifier: ISSN: 0140-6736
fulltext: fulltext
issn:
  • 01406736
  • 0140-6736
url: Link


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titleIntake of trans fatty acids and risk of coronary heart disease among women.
creatorWillett, W C ; Stampfer, M J ; Manson, J E ; Colditz, G A ; Speizer, F E ; Rosner, B A ; Sampson, L A ; Hennekens, C H
contributorWillett, W C (correspondence author) ; Willett, W C (record owner)
ispartofLancet (London, England), March 6, 1993, Vol.341(8845), pp.581-585
identifierISSN: 0140-6736
subjectAge Factors–Blood ; Body Mass Index–Blood ; Cholesterol, HDL–Blood ; Cholesterol, LDL–Epidemiology ; Cohort Studies–Etiology ; Coronary Disease–Adverse Effects ; Diet Surveys–Analysis ; Energy Intake–Chemistry ; Energy Metabolism–Complications ; Exercise–Adverse Effects ; Fatty Acids, Unsaturated–Analysis ; Female–Adverse Effects ; Humans–Epidemiology ; Hydrogenation–Therapeutic Use ; Hypertension–Therapeutic Use ; Margarine–Therapeutic Use ; Nurses–Therapeutic Use ; Proportional Hazards Models–Therapeutic Use ; Risk Factors–Therapeutic Use ; Smoking–Therapeutic Use ; Stereoisomerism–Therapeutic Use ; United States–Therapeutic Use ; Vitamins–Therapeutic Use ; Abridged ; Cholesterol, HDL ; Cholesterol, LDL ; Fatty Acids, Unsaturated ; Vitamins ; Margarine
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descriptionTrans isomers of fatty acids, formed by the partial hydrogenation of vegetable oils to produce margarine and vegetable shortening, increase the ratio of plasma low-density-lipoprotein to high-density-lipoprotein cholesterol, so it is possible that they adversely influence risk of coronary heart disease (CHD). To investigate this possibility, we studied dietary data from participants in the Nurses' Health Study. We calculated intake of trans fatty acids from dietary questionnaires completed by 85 095 women without diagnosed CHD, stroke, diabetes, or hypercholesterolaemia in 1980. During 8 years of follow-up, there were 431 cases of new CHD (non-fatal myocardial infarction or death from CHD). After adjustment for age and total energy intake, intake of trans isomers was directly related to risk of CHD (relative risk for highest vs lowest quintile 1.50 [95% Cl 1.12-2.00], p for trend = 00.001). Additional control for established CHD risk factors, multivitamin use, and intakes of saturated fat, monounsaturated fat, and linoleic acid, dietary cholesterol, vitamins E or C, carotene, or fibre did not change the relative risk substantially. The association was stronger for the 69 181 women whose margarine consumption over the previous 10 years had been stable (1.67 [1.05-2.66], p for trend=0.002). Intakes of foods that are major sources of trans isomers (margarine, cookies [biscuits], cake, and white bread) were each significantly associated with higher risks of CHD. These findings support the hypothesis that consumption of partially hydrogenated vegetable oils may contribute to occurrence of CHD. Lancet 1993; 341: 581-85.
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titleIntake of trans fatty acids and risk of coronary heart disease among women.
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1Body Mass Index–Blood
2Cholesterol, HDL–Blood
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titleIntake of trans fatty acids and risk of coronary heart disease among women.
authorWillett, W C ; Stampfer, M J ; Manson, J E ; Colditz, G A ; Speizer, F E ; Rosner, B A ; Sampson, L A ; Hennekens, C H
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1Body Mass Index–Blood
2Cholesterol, HDL–Blood
3Cholesterol, LDL–Epidemiology
4Cohort Studies–Etiology
5Coronary Disease–Adverse Effects
6Diet Surveys–Analysis
7Energy Intake–Chemistry
8Energy Metabolism–Complications
9Exercise–Adverse Effects
10Fatty Acids, Unsaturated–Analysis
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19Smoking–Therapeutic Use
20Stereoisomerism–Therapeutic Use
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24Cholesterol, HDL
25Cholesterol, LDL
26Fatty Acids, Unsaturated
27Vitamins
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