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PP2A1 binding, cell transducing and apoptotic properties of Vpr(77-92): a new functional domain of HIV-1 Vpr proteins.

BACKGROUNDThe hallmark of HIV-1 pathogenesis is the progressive CD4(+) T cell depletion and high propensity of CD4(+) T cells to apoptosis. HIV-1 viral protein R (Vpr) is a major pro-apoptotic gene product. A first Vpr-mediated apoptotic mechanism that requires a physical interaction of HIV-1 Vpr(71... Full description

Journal Title: PloS one November 1, 2010, Vol.5(11), p.e13760
Main Author: Godet, Angélique N
Other Authors: Guergnon, Julien , Croset, Amélie , Cayla, Xavier , Falanga, Pierre Barthélemy , Colle, Jean-Hervé , Garcia, Alphonse
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0013760
Link: http://search.proquest.com/docview/764549473/?pq-origsite=primo
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title: PP2A1 binding, cell transducing and apoptotic properties of Vpr(77-92): a new functional domain of HIV-1 Vpr proteins.
format: Article
creator:
  • Godet, Angélique N
  • Guergnon, Julien
  • Croset, Amélie
  • Cayla, Xavier
  • Falanga, Pierre Barthélemy
  • Colle, Jean-Hervé
  • Garcia, Alphonse
subjects:
  • Amino Acid Sequence–Drug Effects
  • Apoptosis–Genetics
  • Binding Sites–Drug Effects
  • Biotinylation–Genetics
  • Cell Line, Tumor–Metabolism
  • Hela Cells–Pharmacology
  • Humans–Metabolism
  • In Situ Nick-End Labeling–Chemistry
  • Jurkat Cells–Genetics
  • Membrane Potential, Mitochondrial–Genetics
  • Microscopy, Fluorescence–Genetics
  • Molecular Sequence Data–Genetics
  • Mutation–Genetics
  • Peptide Fragments–Genetics
  • Protein Binding–Genetics
  • Protein Phosphatase 2–Genetics
  • Vpr Gene Products, Human Immunodeficiency Virus–Genetics
  • Peptide Fragments
  • Vpr Gene Products, Human Immunodeficiency Virus
  • Vpr Protein, Human Immunodeficiency Virus 1
  • Ppp2ca Protein, Human
  • Protein Phosphatase 2
ispartof: PloS one, November 1, 2010, Vol.5(11), p.e13760
description: BACKGROUNDThe hallmark of HIV-1 pathogenesis is the progressive CD4(+) T cell depletion and high propensity of CD4(+) T cells to apoptosis. HIV-1 viral protein R (Vpr) is a major pro-apoptotic gene product. A first Vpr-mediated apoptotic mechanism that requires a physical interaction of HIV-1 Vpr(71-82)...
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0013760
fulltext: fulltext
issn:
  • 19326203
  • 1932-6203
url: Link


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titlePP2A1 binding, cell transducing and apoptotic properties of Vpr(77-92): a new functional domain of HIV-1 Vpr proteins.
creatorGodet, Angélique N ; Guergnon, Julien ; Croset, Amélie ; Cayla, Xavier ; Falanga, Pierre Barthélemy ; Colle, Jean-Hervé ; Garcia, Alphonse
contributorGodet, Angélique N (correspondence author) ; Godet, Angélique N (record owner)
ispartofPloS one, November 1, 2010, Vol.5(11), p.e13760
identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0013760
subjectAmino Acid Sequence–Drug Effects ; Apoptosis–Genetics ; Binding Sites–Drug Effects ; Biotinylation–Genetics ; Cell Line, Tumor–Metabolism ; Hela Cells–Pharmacology ; Humans–Metabolism ; In Situ Nick-End Labeling–Chemistry ; Jurkat Cells–Genetics ; Membrane Potential, Mitochondrial–Genetics ; Microscopy, Fluorescence–Genetics ; Molecular Sequence Data–Genetics ; Mutation–Genetics ; Peptide Fragments–Genetics ; Protein Binding–Genetics ; Protein Phosphatase 2–Genetics ; Vpr Gene Products, Human Immunodeficiency Virus–Genetics ; Peptide Fragments ; Vpr Gene Products, Human Immunodeficiency Virus ; Vpr Protein, Human Immunodeficiency Virus 1 ; Ppp2ca Protein, Human ; Protein Phosphatase 2
descriptionBACKGROUNDThe hallmark of HIV-1 pathogenesis is the progressive CD4(+) T cell depletion and high propensity of CD4(+) T cells to apoptosis. HIV-1 viral protein R (Vpr) is a major pro-apoptotic gene product. A first Vpr-mediated apoptotic mechanism that requires a physical interaction of HIV-1 Vpr(71-82)...
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titlePP2A1 binding, cell transducing and apoptotic properties of Vpr(77-92): a new functional domain of HIV-1 Vpr proteins.
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titlePP2A1 binding, cell transducing and apoptotic properties of Vpr(77-92): a new functional domain of HIV-1 Vpr proteins.
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abstractBACKGROUNDThe hallmark of HIV-1 pathogenesis is the progressive CD4(+) T cell depletion and high propensity of CD4(+) T cells to apoptosis. HIV-1 viral protein R (Vpr) is a major pro-apoptotic gene product. A first Vpr-mediated apoptotic mechanism that requires a physical interaction of HIV-1 Vpr(71-82)...
doi10.1371/journal.pone.0013760
urlhttp://search.proquest.com/docview/764549473/
date2010-11-01