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Liposomal bleomycin: increased therapeutic activity and decreased pulmonary toxicity in mice.

Conventional and sterically stabilized liposomes derived from phosphatidylcholine or the antitumor agents, hexadecylphosphocholine and octadecyl-(1,1-dimethyl-4-piperidino-4-yl)-phosphate, as bilayer forming constituents, containing bleomycin, were developed and tested. Liposomal encapsulation of bl... Full description

Journal Title: Drug delivery 2001 Jan-Mar, Vol.8(1), pp.1-7
Main Author: Arndt, D
Other Authors: Zeisig, R , Bechtel, D , Fichtner, I
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1071-7544
Link: http://search.proquest.com/docview/77009038/?pq-origsite=primo
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recordid: proquest77009038
title: Liposomal bleomycin: increased therapeutic activity and decreased pulmonary toxicity in mice.
format: Article
creator:
  • Arndt, D
  • Zeisig, R
  • Bechtel, D
  • Fichtner, I
subjects:
  • Animals–Administration & Dosage
  • Antibiotics, Antineoplastic–Toxicity
  • Bleomycin–Administration & Dosage
  • Dose-Response Relationship, Drug–Toxicity
  • Drug Delivery Systems–Drug Effects
  • Female–Prevention & Control
  • Liposomes–Drug Therapy
  • Lung–Drug Therapy
  • Lung Diseases–Drug Therapy
  • Mice–Drug Therapy
  • Neoplasms, Experimental–Drug Therapy
  • Antibiotics, Antineoplastic
  • Liposomes
  • Bleomycin
ispartof: Drug delivery, 2001 Jan-Mar, Vol.8(1), pp.1-7
description: Conventional and sterically stabilized liposomes derived from phosphatidylcholine or the antitumor agents, hexadecylphosphocholine and octadecyl-(1,1-dimethyl-4-piperidino-4-yl)-phosphate, as bilayer forming constituents, containing bleomycin, were developed and tested. Liposomal encapsulation of bleomycin enhanced strongly the antitumor activity against P388 leukemia and the Lewis lung carcinoma. This effect was clearly dependent on the size and lipid composition of the bleomycin-containing liposomes. The therapeutic effects were nearly equal for liposomal and free bleomycin in the B16 melanoma. The partial replacement of phosphatidylcholine by alkylphospholipids and the inclusion of polyethylene glycol modified lipids for sterical stabilization did not further improve the therapeutic efficacy but increased, in some cases, the toxicity of liposomes. Bleomycin-induced lung injury was not observed if liposomal bleomycin was administered.
language: eng
source:
identifier: ISSN: 1071-7544
fulltext: fulltext
issn:
  • 10717544
  • 1071-7544
url: Link


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titleLiposomal bleomycin: increased therapeutic activity and decreased pulmonary toxicity in mice.
creatorArndt, D ; Zeisig, R ; Bechtel, D ; Fichtner, I
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identifierISSN: 1071-7544
subjectAnimals–Administration & Dosage ; Antibiotics, Antineoplastic–Toxicity ; Bleomycin–Administration & Dosage ; Dose-Response Relationship, Drug–Toxicity ; Drug Delivery Systems–Drug Effects ; Female–Prevention & Control ; Liposomes–Drug Therapy ; Lung–Drug Therapy ; Lung Diseases–Drug Therapy ; Mice–Drug Therapy ; Neoplasms, Experimental–Drug Therapy ; Antibiotics, Antineoplastic ; Liposomes ; Bleomycin
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descriptionConventional and sterically stabilized liposomes derived from phosphatidylcholine or the antitumor agents, hexadecylphosphocholine and octadecyl-(1,1-dimethyl-4-piperidino-4-yl)-phosphate, as bilayer forming constituents, containing bleomycin, were developed and tested. Liposomal encapsulation of bleomycin enhanced strongly the antitumor activity against P388 leukemia and the Lewis lung carcinoma. This effect was clearly dependent on the size and lipid composition of the bleomycin-containing liposomes. The therapeutic effects were nearly equal for liposomal and free bleomycin in the B16 melanoma. The partial replacement of phosphatidylcholine by alkylphospholipids and the inclusion of polyethylene glycol modified lipids for sterical stabilization did not further improve the therapeutic efficacy but increased, in some cases, the toxicity of liposomes. Bleomycin-induced lung injury was not observed if liposomal bleomycin was administered.
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