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Testing of adsorbed diphtheria-pertussis-tetanus (DPT) vaccine for freedom from abnormal toxicity.

A total of 112 samples of adsorbed DPT vaccine were tested in mice for freedom from abnormal toxicity by three procedures: (a) single human dose by intraperitoneal route; (2) single human dose by subcutaneous route; and (3) half the single human dose by intraperitoneal route. The percentage of sampl... Full description

Journal Title: Vaccine April 1990, Vol.8(2), pp.105-106
Main Author: Bhandari, S K
Other Authors: Gupta, R K , Sharma, S B , Pandey, K , Maheshwari, S C , Ahuja, S , Saxena, S N
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0264-410X
Link: http://search.proquest.com/docview/79762899/?pq-origsite=primo
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title: Testing of adsorbed diphtheria-pertussis-tetanus (DPT) vaccine for freedom from abnormal toxicity.
format: Article
creator:
  • Bhandari, S K
  • Gupta, R K
  • Sharma, S B
  • Pandey, K
  • Maheshwari, S C
  • Ahuja, S
  • Saxena, S N
subjects:
  • Animals–Drug Effects
  • Body Weight–Toxicity
  • Diphtheria-Tetanus-Pertussis Vaccine–Toxicity
  • Female–Toxicity
  • Guinea Pigs–Toxicity
  • Injections, Intraperitoneal–Toxicity
  • Injections, Subcutaneous–Toxicity
  • Male–Toxicity
  • Mice–Toxicity
  • Diphtheria-Tetanus-Pertussis Vaccine
ispartof: Vaccine, April 1990, Vol.8(2), pp.105-106
description: A total of 112 samples of adsorbed DPT vaccine were tested in mice for freedom from abnormal toxicity by three procedures: (a) single human dose by intraperitoneal route; (2) single human dose by subcutaneous route; and (3) half the single human dose by intraperitoneal route. The percentage of samples passing by the three methods was 25, 90 and 54.5, respectively. Method 3, which is being recommended now by the World Health Organization, is supported by the results of this study to be neither very stringent nor very lenient to pass the adsorbed DPT vaccine for freedom from abnormal toxicity.
language: eng
source:
identifier: ISSN: 0264-410X
fulltext: fulltext
issn:
  • 0264410X
  • 0264-410X
url: Link


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titleTesting of adsorbed diphtheria-pertussis-tetanus (DPT) vaccine for freedom from abnormal toxicity.
creatorBhandari, S K ; Gupta, R K ; Sharma, S B ; Pandey, K ; Maheshwari, S C ; Ahuja, S ; Saxena, S N
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identifierISSN: 0264-410X
subjectAnimals–Drug Effects ; Body Weight–Toxicity ; Diphtheria-Tetanus-Pertussis Vaccine–Toxicity ; Female–Toxicity ; Guinea Pigs–Toxicity ; Injections, Intraperitoneal–Toxicity ; Injections, Subcutaneous–Toxicity ; Male–Toxicity ; Mice–Toxicity ; Diphtheria-Tetanus-Pertussis Vaccine
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descriptionA total of 112 samples of adsorbed DPT vaccine were tested in mice for freedom from abnormal toxicity by three procedures: (a) single human dose by intraperitoneal route; (2) single human dose by subcutaneous route; and (3) half the single human dose by intraperitoneal route. The percentage of samples passing by the three methods was 25, 90 and 54.5, respectively. Method 3, which is being recommended now by the World Health Organization, is supported by the results of this study to be neither very stringent nor very lenient to pass the adsorbed DPT vaccine for freedom from abnormal toxicity.
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titleTesting of adsorbed diphtheria-pertussis-tetanus (DPT) vaccine for freedom from abnormal toxicity.
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atitleTesting of adsorbed diphtheria-pertussis-tetanus (DPT) vaccine for freedom from abnormal toxicity.
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date1990-04