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Most of the response elicited against Wolbachia surface protein in filarial nematode infection is due to the infective larval stage.

Immune responses to the intracellular Wolbachia bacteria of filarial nematodes are thought to contribute to the pathologic process of filarial infection. Here, we compare antibody responses of subjects living in an area where lymphatic filariasis is endemic with antibody responses elicited in a muri... Full description

Journal Title: The Journal of infectious diseases January 1, 2004, Vol.189(1), pp.120-127
Main Author: Lamb, Tracey J
Other Authors: Le Goff, Laetitia , Kurniawan, Agnes , Guiliano, David B , Fenn, Katelyn , Blaxter, Mark L , Read, Andrew F , Allen, Judith E
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0022-1899
Link: http://search.proquest.com/docview/80080484/?pq-origsite=primo
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recordid: proquest80080484
title: Most of the response elicited against Wolbachia surface protein in filarial nematode infection is due to the infective larval stage.
format: Article
creator:
  • Lamb, Tracey J
  • Le Goff, Laetitia
  • Kurniawan, Agnes
  • Guiliano, David B
  • Fenn, Katelyn
  • Blaxter, Mark L
  • Read, Andrew F
  • Allen, Judith E
subjects:
  • Animals–Blood
  • Antibodies, Bacterial–Blood
  • Antibodies, Helminth–Immunology
  • Bacterial Outer Membrane Proteins–Immunology
  • Brugia Malayi–Microbiology
  • Disease Models, Animal–Physiology
  • Disease Progression–Blood
  • Filariasis–Diagnosis
  • Filarioidea–Microbiology
  • Humans–Physiology
  • Larva–Immunology
  • Male–Immunology
  • Mice–Immunology
  • Mice, Inbred Balb C–Immunology
  • Species Specificity–Immunology
  • Symbiosis–Immunology
  • Wolbachia–Immunology
  • Abridged
  • Antibodies, Bacterial
  • Antibodies, Helminth
  • Bacterial Outer Membrane Proteins
ispartof: The Journal of infectious diseases, January 1, 2004, Vol.189(1), pp.120-127
description: Immune responses to the intracellular Wolbachia bacteria of filarial nematodes are thought to contribute to the pathologic process of filarial infection. Here, we compare antibody responses of subjects living in an area where lymphatic filariasis is endemic with antibody responses elicited in a murine model of filarial infection, to provide evidence that the infective larval stage (L3), not adult nematodes, are the primary inducer of responses against Wolbachia. In human subjects, antibody responses to Brugia malayi Wolbachia surface protein (WSP) are most often correlated with antibody responses to the L3 stage of B. malayi. Analysis of anti-WSP responses induced in mice by different stages of the rodent filariae Litomosoides sigmodontis shows that the strongest anti-WSP response is elicited by the L3 stage. Although adult filarial nematode death may play a role in the generation of an anti-WSP response, it is the L3 stage that is the major source of immunogenic material, and incoming L3 provide a continual boosting of the anti-WSP response. Significant exposure to the endosymbiotic bacteria may occur earlier in nematode infection than previously thought, and the level of exposure to infective insect bites may be a key determinant of disease progression.
language: eng
source:
identifier: ISSN: 0022-1899
fulltext: fulltext
issn:
  • 00221899
  • 0022-1899
url: Link


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titleMost of the response elicited against Wolbachia surface protein in filarial nematode infection is due to the infective larval stage.
creatorLamb, Tracey J ; Le Goff, Laetitia ; Kurniawan, Agnes ; Guiliano, David B ; Fenn, Katelyn ; Blaxter, Mark L ; Read, Andrew F ; Allen, Judith E
contributorLamb, Tracey J (correspondence author) ; Lamb, Tracey J (record owner)
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subjectAnimals–Blood ; Antibodies, Bacterial–Blood ; Antibodies, Helminth–Immunology ; Bacterial Outer Membrane Proteins–Immunology ; Brugia Malayi–Microbiology ; Disease Models, Animal–Physiology ; Disease Progression–Blood ; Filariasis–Diagnosis ; Filarioidea–Microbiology ; Humans–Physiology ; Larva–Immunology ; Male–Immunology ; Mice–Immunology ; Mice, Inbred Balb C–Immunology ; Species Specificity–Immunology ; Symbiosis–Immunology ; Wolbachia–Immunology ; Abridged ; Antibodies, Bacterial ; Antibodies, Helminth ; Bacterial Outer Membrane Proteins
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Immune responses to the intracellular Wolbachia bacteria of filarial nematodes are thought to contribute to the pathologic process of filarial infection. Here, we compare antibody responses of subjects living in an area where lymphatic filariasis is endemic with antibody responses elicited in a murine model of filarial infection, to provide evidence that the infective larval stage (L3), not adult nematodes, are the primary inducer of responses against Wolbachia. In human subjects, antibody responses to Brugia malayi Wolbachia surface protein (WSP) are most often correlated with antibody responses to the L3 stage of B. malayi. Analysis of anti-WSP responses induced in mice by different stages of the rodent filariae Litomosoides sigmodontis shows that the strongest anti-WSP response is elicited by the L3 stage. Although adult filarial nematode death may play a role in the generation of an anti-WSP response, it is the L3 stage that is the major source of immunogenic material, and incoming L3 provide a continual boosting of the anti-WSP response. Significant exposure to the endosymbiotic bacteria may occur earlier in nematode infection than previously thought, and the level of exposure to infective insect bites may be a key determinant of disease progression.

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titleMost of the response elicited against Wolbachia surface protein in filarial nematode infection is due to the infective larval stage.
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titleMost of the response elicited against Wolbachia surface protein in filarial nematode infection is due to the infective larval stage.
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