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Carcinogenic sulfide salts of nickel and cadmium induce H2O2 formation by human polymorphonuclear leukocytes.

Some derivatives of nickel, cadmium, and cobalt are carcinogenic in humans and/or animals but their mechanisms of action are not known. We show that they are capable of stimulating human polymorphonuclear leukocytes (PMNs), as measured by H2O2 formation, a known tumor promoter. Most effective were t... Full description

Journal Title: Cancer research December 1, 1990, Vol.50(23), pp.7564-7570
Main Author: Zhong, Z J
Other Authors: Troll, W , Koenig, K L , Frenkel, K
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0008-5472
Link: http://search.proquest.com/docview/80160705/?pq-origsite=primo
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recordid: proquest80160705
title: Carcinogenic sulfide salts of nickel and cadmium induce H2O2 formation by human polymorphonuclear leukocytes.
format: Article
creator:
  • Zhong, Z J
  • Troll, W
  • Koenig, K L
  • Frenkel, K
subjects:
  • Barium–Pharmacology
  • Barium Compounds–Pharmacology
  • Cadmium–Pharmacology
  • Cadmium Compounds–Pharmacology
  • Catalase–Metabolism
  • Cobalt–Pharmacology
  • Humans–Drug Effects
  • Hydrogen Peroxide–Pharmacology
  • In Vitro Techniques–Pharmacology
  • Manganese–Pharmacology
  • Manganese Compounds–Pharmacology
  • Neutrophils–Pharmacology
  • Nickel–Pharmacology
  • Sulfides–Pharmacology
  • Superoxide Dismutase–Pharmacology
  • Tetradecanoylphorbol Acetate–Pharmacology
  • Barium Compounds
  • Cadmium Compounds
  • Manganese Compounds
  • Sulfides
  • Cadmium
  • Cadmium Sulfide
  • Barium
  • Cobalt
  • Manganese
  • Nickel
  • Manganese Sulfide
  • Hydrogen Peroxide
  • Catalase
  • Superoxide Dismutase
  • Nickel Sulfide
  • Cobaltous Sulfide
  • Tetradecanoylphorbol Acetate
  • Barium Sulfide
ispartof: Cancer research, December 1, 1990, Vol.50(23), pp.7564-7570
description: Some derivatives of nickel, cadmium, and cobalt are carcinogenic in humans and/or animals but their mechanisms of action are not known. We show that they are capable of stimulating human polymorphonuclear leukocytes (PMNs), as measured by H2O2 formation, a known tumor promoter. Most effective were the carcinogens nickel subsulfide, which caused a 550% net increase in H2O2 over that formed by resting PMNs, followed by cadmium sulfide, 400%, and nickel disulfide, 200%. Nickel sulfide and cobalt sulfide caused statistically nonsignificant increases of 45 and 20%, respectively. Noncarcinogenic barium and manganese sulfides, and sulfates of nickel, cadmium, and cobalt were inactive. The enhancement of H2O2 formation by CdS and Ni3S2 (1 mumol/2.5 x 10(5) PMNs) was comparable to that mediated by the potent tumor promoter 12-O-tetradecanoylphorbol-13-acetate, used at 0.5 and 1 nM, respectively. Concurrent treatment of 12-O-tetradecanoylphorbol-13-acetate-stimulated PMNs with Ni3S2 or NiS caused a decrease in H2O2 accumulation from that expected if the effects were additive. Including catalase in the reaction mixture proved that the oxidant formed by stimulated PMNs was H2O2, whereas adding superoxide dismutase showed that superoxide was also present in PMN samples treated with NiS but not with Ni3S2. Since nickel- and cadmium-containing particulates are deposited in the lungs and cause infiltration of PMNs, the ability to activate those cells and induce H2O2 formation may contribute to their carcinogenicity.
language: eng
source:
identifier: ISSN: 0008-5472
fulltext: fulltext
issn:
  • 00085472
  • 0008-5472
url: Link


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titleCarcinogenic sulfide salts of nickel and cadmium induce H2O2 formation by human polymorphonuclear leukocytes.
creatorZhong, Z J ; Troll, W ; Koenig, K L ; Frenkel, K
contributorZhong, Z J (correspondence author) ; Zhong, Z J (record owner)
ispartofCancer research, December 1, 1990, Vol.50(23), pp.7564-7570
identifierISSN: 0008-5472
subjectBarium–Pharmacology ; Barium Compounds–Pharmacology ; Cadmium–Pharmacology ; Cadmium Compounds–Pharmacology ; Catalase–Metabolism ; Cobalt–Pharmacology ; Humans–Drug Effects ; Hydrogen Peroxide–Pharmacology ; In Vitro Techniques–Pharmacology ; Manganese–Pharmacology ; Manganese Compounds–Pharmacology ; Neutrophils–Pharmacology ; Nickel–Pharmacology ; Sulfides–Pharmacology ; Superoxide Dismutase–Pharmacology ; Tetradecanoylphorbol Acetate–Pharmacology ; Barium Compounds ; Cadmium Compounds ; Manganese Compounds ; Sulfides ; Cadmium ; Cadmium Sulfide ; Barium ; Cobalt ; Manganese ; Nickel ; Manganese Sulfide ; Hydrogen Peroxide ; Catalase ; Superoxide Dismutase ; Nickel Sulfide ; Cobaltous Sulfide ; Tetradecanoylphorbol Acetate ; Barium Sulfide
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descriptionSome derivatives of nickel, cadmium, and cobalt are carcinogenic in humans and/or animals but their mechanisms of action are not known. We show that they are capable of stimulating human polymorphonuclear leukocytes (PMNs), as measured by H2O2 formation, a known tumor promoter. Most effective were the carcinogens nickel subsulfide, which caused a 550% net increase in H2O2 over that formed by resting PMNs, followed by cadmium sulfide, 400%, and nickel disulfide, 200%. Nickel sulfide and cobalt sulfide caused statistically nonsignificant increases of 45 and 20%, respectively. Noncarcinogenic barium and manganese sulfides, and sulfates of nickel, cadmium, and cobalt were inactive. The enhancement of H2O2 formation by CdS and Ni3S2 (1 mumol/2.5 x 10(5) PMNs) was comparable to that mediated by the potent tumor promoter 12-O-tetradecanoylphorbol-13-acetate, used at 0.5 and 1 nM, respectively. Concurrent treatment of 12-O-tetradecanoylphorbol-13-acetate-stimulated PMNs with Ni3S2 or NiS caused a decrease in H2O2 accumulation from that expected if the effects were additive. Including catalase in the reaction mixture proved that the oxidant formed by stimulated PMNs was H2O2, whereas adding superoxide dismutase showed that superoxide was also present in PMN samples treated with NiS but not with Ni3S2. Since nickel- and cadmium-containing particulates are deposited in the lungs and cause infiltration of PMNs, the ability to activate those cells and induce H2O2 formation may contribute to their carcinogenicity.
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0Barium–Pharmacology
1Barium Compounds–Pharmacology
2Cadmium–Pharmacology
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6Humans–Drug Effects
7Hydrogen Peroxide–Pharmacology
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11Neutrophils–Pharmacology
12Nickel–Pharmacology
13Sulfides–Pharmacology
14Superoxide Dismutase–Pharmacology
15Tetradecanoylphorbol Acetate–Pharmacology
16Barium Compounds
17Cadmium Compounds
18Manganese Compounds
19Sulfides
20Cadmium
21Cadmium Sulfide
22Barium
23Cobalt
24Manganese
25Nickel
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27Hydrogen Peroxide
28Catalase
29Superoxide Dismutase
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32Tetradecanoylphorbol Acetate
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citationpf 7564 pt 7570 vol 50 issue 23
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titleCarcinogenic sulfide salts of nickel and cadmium induce H2O2 formation by human polymorphonuclear leukocytes.
authorZhong, Z J ; Troll, W ; Koenig, K L ; Frenkel, K
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1Barium Compounds–Pharmacology
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3Cadmium Compounds–Pharmacology
4Catalase–Metabolism
5Cobalt–Pharmacology
6Humans–Drug Effects
7Hydrogen Peroxide–Pharmacology
8In Vitro Techniques–Pharmacology
9Manganese–Pharmacology
10Manganese Compounds–Pharmacology
11Neutrophils–Pharmacology
12Nickel–Pharmacology
13Sulfides–Pharmacology
14Superoxide Dismutase–Pharmacology
15Tetradecanoylphorbol Acetate–Pharmacology
16Barium Compounds
17Cadmium Compounds
18Manganese Compounds
19Sulfides
20Cadmium
21Cadmium Sulfide
22Barium
23Cobalt
24Manganese
25Nickel
26Manganese Sulfide
27Hydrogen Peroxide
28Catalase
29Superoxide Dismutase
30Nickel Sulfide
31Cobaltous Sulfide
32Tetradecanoylphorbol Acetate
33Barium Sulfide
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