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Measurement of prostate-specific antigen in serum as a screening test for prostate cancer.

BACKGROUNDProstate-specific antigen (PSA) is secreted exclusively by prostatic epithelial cells, and its serum concentration is increased in men with prostatic disease, including cancer. We evaluated its usefulness in the detection and staging of prostate cancer. METHODSWe measured serum PSA concent... Full description

Journal Title: The New England journal of medicine April 25, 1991, Vol.324(17), pp.1156-1161
Main Author: Catalona, W J
Other Authors: Smith, D S , Ratliff, T L , Dodds, K M , Coplen, D E , Yuan, J J , Petros, J A , Andriole, G L
Format: Electronic Article Electronic Article
Language: English
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ID: ISSN: 0028-4793
Link: http://search.proquest.com/docview/80496442/?pq-origsite=primo
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title: Measurement of prostate-specific antigen in serum as a screening test for prostate cancer.
format: Article
creator:
  • Catalona, W J
  • Smith, D S
  • Ratliff, T L
  • Dodds, K M
  • Coplen, D E
  • Yuan, J J
  • Petros, J A
  • Andriole, G L
subjects:
  • Age Factors–Blood
  • Aged–Blood
  • Aged, 80 and Over–Immunology
  • Antigens, Neoplasm–Immunology
  • Biomarkers, Tumor–Diagnosis
  • Biopsy–Diagnostic Imaging
  • Epithelium–Diagnostic Imaging
  • Humans–Diagnostic Imaging
  • Male–Diagnostic Imaging
  • Middle Aged–Diagnostic Imaging
  • Neoplasm Staging–Diagnostic Imaging
  • Palpation–Diagnostic Imaging
  • Prostate–Diagnostic Imaging
  • Prostate-Specific Antigen–Diagnostic Imaging
  • Prostatic Neoplasms–Diagnostic Imaging
  • Ultrasonography–Diagnostic Imaging
  • Abridged
  • Antigens, Neoplasm
  • Biomarkers, Tumor
  • Prostate-Specific Antigen
ispartof: The New England journal of medicine, April 25, 1991, Vol.324(17), pp.1156-1161
description: BACKGROUNDProstate-specific antigen (PSA) is secreted exclusively by prostatic epithelial cells, and its serum concentration is increased in men with prostatic disease, including cancer. We evaluated its usefulness in the detection and staging of prostate cancer. METHODSWe measured serum PSA concentrations in 1653 healthy men 50 or more years old. Those with PSA values greater than or equal to 4.0 micrograms per liter then underwent rectal examination and prostatic ultrasonography. Ultrasound-directed prostatic needle biopsies were performed in the men with abnormal findings on rectal examination, ultrasonography, or both. The results were compared with those in 300 consecutively studied men 50 or more years old who underwent ultrasound-directed biopsy because of symptoms or abnormal findings on rectal examination. RESULTSSerum PSA levels ranged from 4.0 to 9.9 micrograms per liter in 6.5 percent of the 1653 men (107). Nineteen of the 85 men in this group (22 percent) who had prostatic...
language: eng
source:
identifier: ISSN: 0028-4793
fulltext: fulltext
issn:
  • 00284793
  • 0028-4793
url: Link


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titleMeasurement of prostate-specific antigen in serum as a screening test for prostate cancer.
creatorCatalona, W J ; Smith, D S ; Ratliff, T L ; Dodds, K M ; Coplen, D E ; Yuan, J J ; Petros, J A ; Andriole, G L
contributorCatalona, W J (correspondence author) ; Catalona, W J (record owner)
ispartofThe New England journal of medicine, April 25, 1991, Vol.324(17), pp.1156-1161
identifierISSN: 0028-4793
subjectAge Factors–Blood ; Aged–Blood ; Aged, 80 and Over–Immunology ; Antigens, Neoplasm–Immunology ; Biomarkers, Tumor–Diagnosis ; Biopsy–Diagnostic Imaging ; Epithelium–Diagnostic Imaging ; Humans–Diagnostic Imaging ; Male–Diagnostic Imaging ; Middle Aged–Diagnostic Imaging ; Neoplasm Staging–Diagnostic Imaging ; Palpation–Diagnostic Imaging ; Prostate–Diagnostic Imaging ; Prostate-Specific Antigen–Diagnostic Imaging ; Prostatic Neoplasms–Diagnostic Imaging ; Ultrasonography–Diagnostic Imaging ; Abridged ; Antigens, Neoplasm ; Biomarkers, Tumor ; Prostate-Specific Antigen
descriptionBACKGROUNDProstate-specific antigen (PSA) is secreted exclusively by prostatic epithelial cells, and its serum concentration is increased in men with prostatic disease, including cancer. We evaluated its usefulness in the detection and staging of prostate cancer. METHODSWe measured serum PSA concentrations in 1653 healthy men 50 or more years old. Those with PSA values greater than or equal to 4.0 micrograms per liter then underwent rectal examination and prostatic ultrasonography. Ultrasound-directed prostatic needle biopsies were performed in the men with abnormal findings on rectal examination, ultrasonography, or both. The results were compared with those in 300 consecutively studied men 50 or more years old who underwent ultrasound-directed biopsy because of symptoms or abnormal findings on rectal examination. RESULTSSerum PSA levels ranged from 4.0 to 9.9 micrograms per liter in 6.5 percent of the 1653 men (107). Nineteen of the 85 men in this group (22 percent) who had prostatic...
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titleMeasurement of prostate-specific antigen in serum as a screening test for prostate cancer.
descriptionBACKGROUNDProstate-specific antigen (PSA) is secreted exclusively by prostatic epithelial cells, and its serum concentration is increased in men with prostatic disease, including cancer. We evaluated its usefulness in the detection and staging of prostate cancer. METHODSWe measured serum PSA concentrations in 1653 healthy men 50 or more years old. Those with PSA values greater than or equal to 4.0 micrograms per liter then underwent rectal examination and prostatic ultrasonography. Ultrasound-directed prostatic needle biopsies were performed in the men with abnormal findings on rectal examination, ultrasonography, or both. The results were compared with those in 300 consecutively studied men 50 or more years old who underwent ultrasound-directed biopsy because of symptoms or abnormal findings on rectal examination. RESULTSSerum PSA levels ranged from 4.0 to 9.9 micrograms per liter in 6.5 percent of the 1653 men (107). Nineteen of the 85 men in this group (22 percent) who had prostatic...
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titleMeasurement of prostate-specific antigen in serum as a screening test for prostate cancer.
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abstractBACKGROUNDProstate-specific antigen (PSA) is secreted exclusively by prostatic epithelial cells, and its serum concentration is increased in men with prostatic disease, including cancer. We evaluated its usefulness in the detection and staging of prostate cancer. METHODSWe measured serum PSA concentrations in 1653 healthy men 50 or more years old. Those with PSA values greater than or equal to 4.0 micrograms per liter then underwent rectal examination and prostatic ultrasonography. Ultrasound-directed prostatic needle biopsies were performed in the men with abnormal findings on rectal examination, ultrasonography, or both. The results were compared with those in 300 consecutively studied men 50 or more years old who underwent ultrasound-directed biopsy because of symptoms or abnormal findings on rectal examination. RESULTSSerum PSA levels ranged from 4.0 to 9.9 micrograms per liter in 6.5 percent of the 1653 men (107). Nineteen of the 85 men in this group (22 percent) who had prostatic...
urlhttp://search.proquest.com/docview/80496442/
doi10.1056/NEJM199104253241702
eissn15334406
date1991-04-25