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Solution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist.

The structure of kistrin, which is a member of a homologous family of glycoprotein IIb-IIIa (GP IIb-IIIa) antagonists and potent protein inhibitors of platelet aggregation, has been determined by two-dimensional nuclear magnetic resonance (NMR) spectroscopy. The 68-residue protein consists of a seri... Full description

Journal Title: Science (New York N.Y.), July 26, 1991, Vol.253(5018), pp.445-448
Main Author: Adler, M
Other Authors: Lazarus, R A , Dennis, M S , Wagner, G
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0036-8075
Link: http://search.proquest.com/docview/80717525/?pq-origsite=primo
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recordid: proquest80717525
title: Solution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist.
format: Article
creator:
  • Adler, M
  • Lazarus, R A
  • Dennis, M S
  • Wagner, G
subjects:
  • Amino Acid Sequence–Chemistry
  • Glycoproteins–Chemistry
  • Humans–Genetics
  • Magnetic Resonance Spectroscopy–Chemistry
  • Models, Molecular–Antagonists & Inhibitors
  • Molecular Sequence Data–Antagonists & Inhibitors
  • Mutagenesis, Site-Directed–Antagonists & Inhibitors
  • Peptides–Antagonists & Inhibitors
  • Platelet Aggregation Inhibitors–Antagonists & Inhibitors
  • Platelet Membrane Glycoproteins–Antagonists & Inhibitors
  • Protein Conformation–Antagonists & Inhibitors
  • Glycoproteins
  • Peptides
  • Platelet Aggregation Inhibitors
  • Platelet Membrane Glycoproteins
  • Kistrin
ispartof: Science (New York, N.Y.), July 26, 1991, Vol.253(5018), pp.445-448
description: The structure of kistrin, which is a member of a homologous family of glycoprotein IIb-IIIa (GP IIb-IIIa) antagonists and potent protein inhibitors of platelet aggregation, has been determined by two-dimensional nuclear magnetic resonance (NMR) spectroscopy. The 68-residue protein consists of a series of tightly packed loops held together by six disulfide bonds and has almost no regular secondary structure. Kistrin has an Arg-Gly-Asp (RGD)adhesion site recognition sequence important for binding to GP IIb-IIIa that is located at the apex of a long loop across the surface of the protein.
language: eng
source:
identifier: ISSN: 0036-8075
fulltext: fulltext
issn:
  • 00368075
  • 0036-8075
url: Link


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titleSolution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist.
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The structure of kistrin, which is a member of a homologous family of glycoprotein IIb-IIIa (GP IIb-IIIa) antagonists and potent protein inhibitors of platelet aggregation, has been determined by two-dimensional nuclear magnetic resonance (NMR) spectroscopy. The 68-residue protein consists of a series of tightly packed loops held together by six disulfide bonds and has almost no regular secondary structure. Kistrin has an Arg-Gly-Asp (RGD)adhesion site recognition sequence important for binding to GP IIb-IIIa that is located at the apex of a long loop across the surface of the protein.

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6Mutagenesis, Site-Directed–Antagonists & Inhibitors
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titleSolution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist.
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5Molecular Sequence Data–Antagonists & Inhibitors
6Mutagenesis, Site-Directed–Antagonists & Inhibitors
7Peptides–Antagonists & Inhibitors
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9Platelet Membrane Glycoproteins–Antagonists & Inhibitors
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date1991-07-26