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Adiponectin reduces C-reactive protein expression and downregulates STAT3 phosphorylation induced by IL-6 in HepG2 cells

By playing a direct proatherogenic role, C-reactive protein (CRP) is a potent independent predictor of future cardiovascular events. CRP is predominately synthesized by hepatocytes when stimulated by interleukin-6 (IL-6). In response to IL-6, the signal transducer and activator of transcription 3 (S... Full description

Journal Title: Molecular and Cellular Biochemistry Jan 2011, Vol.347(1-2), pp.183-9
Main Author: Sun, Haiyun
Other Authors: Zhang, Yingnan , Gao, Ping , Li, Qiang , Sun, Yuqian , Zhang, Jinchao , Xu, Changqing
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 03008177 ; E-ISSN: 15734919 ; DOI: 10.1007/s11010-010-0627-y
Link: http://search.proquest.com/docview/822742649/?pq-origsite=primo
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title: Adiponectin reduces C-reactive protein expression and downregulates STAT3 phosphorylation induced by IL-6 in HepG2 cells
format: Article
creator:
  • Sun, Haiyun
  • Zhang, Yingnan
  • Gao, Ping
  • Li, Qiang
  • Sun, Yuqian
  • Zhang, Jinchao
  • Xu, Changqing
subjects:
  • Adiponectin–Pharmacology
  • C-Reactive Protein–Genetics
  • C-Reactive Protein–Metabolism
  • Down-Regulation–Drug Effects
  • Hep G2 Cells–Pharmacology
  • Humans–Drug Effects
  • Interleukin-6–Genetics
  • Phosphorylation–Metabolism
  • RNA, Messenger–Metabolism
  • RNA, Messenger–Metabolism
  • Stat3 Transcription Factor–Metabolism
  • Phosphorylation
  • Biochemistry
  • Gene Expression
  • Proteins
  • Cardiovascular Disease
  • Adiponectin
  • Interleukin-6
  • RNA, Messenger
  • Stat3 Transcription Factor
ispartof: Molecular and Cellular Biochemistry, Jan 2011, Vol.347(1-2), pp.183-9
description: By playing a direct proatherogenic role, C-reactive protein (CRP) is a potent independent predictor of future cardiovascular events. CRP is predominately synthesized by hepatocytes when stimulated by interleukin-6 (IL-6). In response to IL-6, the signal transducer and activator of transcription 3 (STAT3) becomes phosphorylated on tyrosine and serine residues. Phosphorylated STAT3 then activates CRP gene transcription. In obesity-related disorders such as diabetes, metabolic syndrome, and cardiovascular diseases, the circulating levels of CRP and adiponectin are inversely correlated, suggesting that these two factors might reciprocally regulate each other. We investigated the possibility that adiponectin inhibits CRP production in HepG^sub 2^ cells elicited by IL-6. CRP gene expression was determined using ELISA and semi-quantitative RT-PCR, and the phosphorylation of STAT3 was investigated with western blot. Adiponectin reduced IL-6-induced CRP mRNA levels in HepG^sub 2^ cells and CRP protein...
language: eng
source:
identifier: ISSN: 03008177 ; E-ISSN: 15734919 ; DOI: 10.1007/s11010-010-0627-y
fulltext: fulltext
issn:
  • 03008177
  • 0300-8177
  • 15734919
  • 1573-4919
url: Link


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titleAdiponectin reduces C-reactive protein expression and downregulates STAT3 phosphorylation induced by IL-6 in HepG2 cells
creatorSun, Haiyun ; Zhang, Yingnan ; Gao, Ping ; Li, Qiang ; Sun, Yuqian ; Zhang, Jinchao ; Xu, Changqing
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subjectAdiponectin–Pharmacology ; C-Reactive Protein–Genetics ; C-Reactive Protein–Metabolism ; Down-Regulation–Drug Effects ; Hep G2 Cells–Pharmacology ; Humans–Drug Effects ; Interleukin-6–Genetics ; Phosphorylation–Metabolism ; RNA, Messenger–Metabolism ; RNA, Messenger–Metabolism ; Stat3 Transcription Factor–Metabolism ; Phosphorylation ; Biochemistry ; Gene Expression ; Proteins ; Cardiovascular Disease ; Adiponectin ; Interleukin-6 ; RNA, Messenger ; Stat3 Transcription Factor
descriptionBy playing a direct proatherogenic role, C-reactive protein (CRP) is a potent independent predictor of future cardiovascular events. CRP is predominately synthesized by hepatocytes when stimulated by interleukin-6 (IL-6). In response to IL-6, the signal transducer and activator of transcription 3 (STAT3) becomes phosphorylated on tyrosine and serine residues. Phosphorylated STAT3 then activates CRP gene transcription. In obesity-related disorders such as diabetes, metabolic syndrome, and cardiovascular diseases, the circulating levels of CRP and adiponectin are inversely correlated, suggesting that these two factors might reciprocally regulate each other. We investigated the possibility that adiponectin inhibits CRP production in HepG^sub 2^ cells elicited by IL-6. CRP gene expression was determined using ELISA and semi-quantitative RT-PCR, and the phosphorylation of STAT3 was investigated with western blot. Adiponectin reduced IL-6-induced CRP mRNA levels in HepG^sub 2^ cells and CRP protein...
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descriptionBy playing a direct proatherogenic role, C-reactive protein (CRP) is a potent independent predictor of future cardiovascular events. CRP is predominately synthesized by hepatocytes when stimulated by interleukin-6 (IL-6). In response to IL-6, the signal transducer and activator of transcription 3 (STAT3) becomes phosphorylated on tyrosine and serine residues. Phosphorylated STAT3 then activates CRP gene transcription. In obesity-related disorders such as diabetes, metabolic syndrome, and cardiovascular diseases, the circulating levels of CRP and adiponectin are inversely correlated, suggesting that these two factors might reciprocally regulate each other. We investigated the possibility that adiponectin inhibits CRP production in HepG^sub 2^ cells elicited by IL-6. CRP gene expression was determined using ELISA and semi-quantitative RT-PCR, and the phosphorylation of STAT3 was investigated with western blot. Adiponectin reduced IL-6-induced CRP mRNA levels in HepG^sub 2^ cells and CRP protein...
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titleAdiponectin reduces C-reactive protein expression and downregulates STAT3 phosphorylation induced by IL-6 in HepG2 cells
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abstractBy playing a direct proatherogenic role, C-reactive protein (CRP) is a potent independent predictor of future cardiovascular events. CRP is predominately synthesized by hepatocytes when stimulated by interleukin-6 (IL-6). In response to IL-6, the signal transducer and activator of transcription 3 (STAT3) becomes phosphorylated on tyrosine and serine residues. Phosphorylated STAT3 then activates CRP gene transcription. In obesity-related disorders such as diabetes, metabolic syndrome, and cardiovascular diseases, the circulating levels of CRP and adiponectin are inversely correlated, suggesting that these two factors might reciprocally regulate each other. We investigated the possibility that adiponectin inhibits CRP production in HepG^sub 2^ cells elicited by IL-6. CRP gene expression was determined using ELISA and semi-quantitative RT-PCR, and the phosphorylation of STAT3 was investigated with western blot. Adiponectin reduced IL-6-induced CRP mRNA levels in HepG^sub 2^ cells and CRP protein...
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