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Antitumor vaccination by Newcastle Disease Virus Hemagglutinin-Neuraminidase plasmid DNA application: changes in tumor microenvironment and activation of innate anti-tumor immunity.

A plasmid encoding the Hemagglutinin-Neuraminidase (HN) protein of Newcastle Disease Virus (pHN) was tested for its capacity to stimulate innate anti-tumor activity in tumor-bearing mice. We observed that application of the pHN plasmid at the ear pinna site (i.e.) of mice induces higher levels of sy... Full description

Journal Title: Vaccine February 1, 2011, Vol.29(6), pp.1185-1193
Main Author: Ni, Jing
Other Authors: Galani, Ioanna E , Cerwenka, Adelheid , Schirrmacher, Volker , Fournier, Philippe
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1873-2518 ; DOI: 10.1016/j.vaccine.2010.12.005
Link: http://search.proquest.com/docview/847285526/?pq-origsite=primo
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title: Antitumor vaccination by Newcastle Disease Virus Hemagglutinin-Neuraminidase plasmid DNA application: changes in tumor microenvironment and activation of innate anti-tumor immunity.
format: Article
creator:
  • Ni, Jing
  • Galani, Ioanna E
  • Cerwenka, Adelheid
  • Schirrmacher, Volker
  • Fournier, Philippe
subjects:
  • Animals–Genetics
  • Cancer Vaccines–Immunology
  • Disease Models, Animal–Genetics
  • Drug Carriers–Immunology
  • Female–Immunology
  • Genetic Vectors–Immunology
  • Hn Protein–Prevention & Control
  • Immunity–Genetics
  • Immunity, Innate–Immunology
  • Interferon Type I–Immunology
  • Killer Cells, Natural–Immunology
  • Mammary Neoplasms, Animal–Immunology
  • Mice–Immunology
  • Mice, Inbred Balb C–Immunology
  • Neoplasms–Immunology
  • Newcastle Disease Virus–Immunology
  • Plasmids–Immunology
  • Tumor Microenvironment–Immunology
  • Cancer Vaccines
ispartof: Vaccine, February 1, 2011, Vol.29(6), pp.1185-1193
description: A plasmid encoding the Hemagglutinin-Neuraminidase (HN) protein of Newcastle Disease Virus (pHN) was tested for its capacity to stimulate innate anti-tumor activity in tumor-bearing mice. We observed that application of the pHN plasmid at the ear pinna site (i.e.) of mice induces higher levels of systemic interferon- alpha and reduced tumor growth in the prophylactic mammary carcinoma DA3 tumor model in comparison to application of a control plasmid not encoding the HN protein. Analysis of the tumor microenvironment revealed a significant increase in NK cell infiltration and decrease in infiltration of CD11b super(+)Gr-1 super(high) myeloid cells bearing the myeloid-derived suppressor cell (MDSC) phenotype after vaccination with the pHN DNA compared to a control DNA. Finally, innate immunity and partially type delta IFN responses were proved important for the reduction of s.c. RMA-S tumor growth after pHN vaccination, as shown with the use of RAG2 super(-/-) and RAG2 super(-/-)IFNAR1 super(-/-) mice. These data demonstrate that triggering innate immunity by pHN application at the ear pinna of mice modulates the immune cell compartment in the tumor microenvironment and reduces tumor growth. This highlights thus the potential adjuvant activity of the HN gene in tumor therapy.
language: eng
source:
identifier: E-ISSN: 1873-2518 ; DOI: 10.1016/j.vaccine.2010.12.005
fulltext: fulltext
issn:
  • 18732518
  • 1873-2518
url: Link


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titleAntitumor vaccination by Newcastle Disease Virus Hemagglutinin-Neuraminidase plasmid DNA application: changes in tumor microenvironment and activation of innate anti-tumor immunity.
creatorNi, Jing ; Galani, Ioanna E ; Cerwenka, Adelheid ; Schirrmacher, Volker ; Fournier, Philippe
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ispartofVaccine, February 1, 2011, Vol.29(6), pp.1185-1193
identifierE-ISSN: 1873-2518 ; DOI: 10.1016/j.vaccine.2010.12.005
subjectAnimals–Genetics ; Cancer Vaccines–Immunology ; Disease Models, Animal–Genetics ; Drug Carriers–Immunology ; Female–Immunology ; Genetic Vectors–Immunology ; Hn Protein–Prevention & Control ; Immunity–Genetics ; Immunity, Innate–Immunology ; Interferon Type I–Immunology ; Killer Cells, Natural–Immunology ; Mammary Neoplasms, Animal–Immunology ; Mice–Immunology ; Mice, Inbred Balb C–Immunology ; Neoplasms–Immunology ; Newcastle Disease Virus–Immunology ; Plasmids–Immunology ; Tumor Microenvironment–Immunology ; Cancer Vaccines
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descriptionA plasmid encoding the Hemagglutinin-Neuraminidase (HN) protein of Newcastle Disease Virus (pHN) was tested for its capacity to stimulate innate anti-tumor activity in tumor-bearing mice. We observed that application of the pHN plasmid at the ear pinna site (i.e.) of mice induces higher levels of systemic interferon- alpha and reduced tumor growth in the prophylactic mammary carcinoma DA3 tumor model in comparison to application of a control plasmid not encoding the HN protein. Analysis of the tumor microenvironment revealed a significant increase in NK cell infiltration and decrease in infiltration of CD11b super(+)Gr-1 super(high) myeloid cells bearing the myeloid-derived suppressor cell (MDSC) phenotype after vaccination with the pHN DNA compared to a control DNA. Finally, innate immunity and partially type delta IFN responses were proved important for the reduction of s.c. RMA-S tumor growth after pHN vaccination, as shown with the use of RAG2 super(-/-) and RAG2 super(-/-)IFNAR1 super(-/-) mice. These data demonstrate that triggering innate immunity by pHN application at the ear pinna of mice modulates the immune cell compartment in the tumor microenvironment and reduces tumor growth. This highlights thus the potential adjuvant activity of the HN gene in tumor therapy.
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