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RA-inducible gene-I induction augments STAT1 activation to inhibit leukemia cell proliferation.

RA-inducible gene I (RIG-I/DDX58) has been shown to activate IFN-[beta] promoter stimulator 1 (IPS-1) on recognizing cytoplasmic viral RNAs. It is unclear how RIG-I functions within the IFN and/or PA signaling process in acute myeloid leukemia (AML) cells, however, where obvious RIG-I induction is o... Full description

Journal Title: Proceedings of the National Academy of Sciences of the United States of America February 1, 2011, Vol.108(5), pp.1897-1902
Main Author: Jiang, Lin-Jia
Other Authors: Zhang, Nan-Nan , Ding, Fei , Li, Xian-Yang , Chen, Lei , Zhang, Hong-Xin , Zhang, Wu , Chen, Sai-Juan , Wang, Zhu-Gang , Li, Jun-Min , Chen, Zhu , Zhu, Jiang
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1091-6490 ; DOI: 10.1073/pnas.1019059108
Link: http://search.proquest.com/docview/849012677/?pq-origsite=primo
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title: RA-inducible gene-I induction augments STAT1 activation to inhibit leukemia cell proliferation.
format: Article
creator:
  • Jiang, Lin-Jia
  • Zhang, Nan-Nan
  • Ding, Fei
  • Li, Xian-Yang
  • Chen, Lei
  • Zhang, Hong-Xin
  • Zhang, Wu
  • Chen, Sai-Juan
  • Wang, Zhu-Gang
  • Li, Jun-Min
  • Chen, Zhu
  • Zhu, Jiang
subjects:
  • Cell Proliferation–Genetics
  • Dead Box Protein 58–Drug Effects
  • Dead-Box RNA Helicases–Pathology
  • Gene Expression Regulation–Metabolism
  • Humans–Pharmacology
  • Leukemia–Pharmacology
  • Stat1 Transcription Factor–Pharmacology
  • Tretinoin–Pharmacology
  • U937 Cells–Pharmacology
  • Stat1 Transcription Factor
  • Stat1 Protein, Human
  • Tretinoin
  • Ddx58 Protein, Human
  • Dead Box Protein 58
  • Dead-Box RNA Helicases
ispartof: Proceedings of the National Academy of Sciences of the United States of America, February 1, 2011, Vol.108(5), pp.1897-1902
description: RA-inducible gene I (RIG-I/DDX58) has been shown to activate IFN-[beta] promoter stimulator 1 (IPS-1) on recognizing cytoplasmic viral RNAs. It is unclear how RIG-I functions within the IFN and/or PA signaling process in acute myeloid leukemia (AML) cells, however, where obvious RIG-I induction is observed. Here, we show that the RIG-I induction functionally contributes to IFN-[alpha] plus RA-triggered growth inhibition of AML cells. Interestingly, although RIG-I induction itself is under the regulation of STAT1, a major IFN intracellular signal mediator, under circumstances in which it does not stimulate IPS-1, it conversely augments STAT1 activation to induce IFN-stimulatory gene expression and inhibit leukemia cell proliferation. Thus, our results unveil a previously undescribed RIG-I activity in regulating the cellular proliferation of leukemia cells via STAT1, which is independent of its classic role of sensing viral invasion to trigger type I IFN transcription. doi/ 10.1073/pnas.1019059108
language: eng
source:
identifier: E-ISSN: 1091-6490 ; DOI: 10.1073/pnas.1019059108
fulltext: fulltext
issn:
  • 10916490
  • 1091-6490
url: Link


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titleRA-inducible gene-I induction augments STAT1 activation to inhibit leukemia cell proliferation.
creatorJiang, Lin-Jia ; Zhang, Nan-Nan ; Ding, Fei ; Li, Xian-Yang ; Chen, Lei ; Zhang, Hong-Xin ; Zhang, Wu ; Chen, Sai-Juan ; Wang, Zhu-Gang ; Li, Jun-Min ; Chen, Zhu ; Zhu, Jiang
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identifierE-ISSN: 1091-6490 ; DOI: 10.1073/pnas.1019059108
subjectCell Proliferation–Genetics ; Dead Box Protein 58–Drug Effects ; Dead-Box RNA Helicases–Pathology ; Gene Expression Regulation–Metabolism ; Humans–Pharmacology ; Leukemia–Pharmacology ; Stat1 Transcription Factor–Pharmacology ; Tretinoin–Pharmacology ; U937 Cells–Pharmacology ; Stat1 Transcription Factor ; Stat1 Protein, Human ; Tretinoin ; Ddx58 Protein, Human ; Dead Box Protein 58 ; Dead-Box RNA Helicases
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descriptionRA-inducible gene I (RIG-I/DDX58) has been shown to activate IFN-[beta] promoter stimulator 1 (IPS-1) on recognizing cytoplasmic viral RNAs. It is unclear how RIG-I functions within the IFN and/or PA signaling process in acute myeloid leukemia (AML) cells, however, where obvious RIG-I induction is observed. Here, we show that the RIG-I induction functionally contributes to IFN-[alpha] plus RA-triggered growth inhibition of AML cells. Interestingly, although RIG-I induction itself is under the regulation of STAT1, a major IFN intracellular signal mediator, under circumstances in which it does not stimulate IPS-1, it conversely augments STAT1 activation to induce IFN-stimulatory gene expression and inhibit leukemia cell proliferation. Thus, our results unveil a previously undescribed RIG-I activity in regulating the cellular proliferation of leukemia cells via STAT1, which is independent of its classic role of sensing viral invasion to trigger type I IFN transcription. doi/ 10.1073/pnas.1019059108
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