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Investigating spectrum of biological activity of 4- and 5-chloro-2-hydroxy-N-[2-(arylamino)-1-alkyl-2-oxoethyl]benzamides.

In this study, a series of twenty-two 5-chloro-2-hydroxy- N -[2-(arylamino)-1-alkyl-2-oxoethyl]benzamides and ten 4-chloro-2-hydroxy- N -[2-(arylamino)-1-alkyl-2-oxoethyl]benzamides is described. The compounds were analyzed using RP-HPLC to determine lipophilicity. Primary in vitro screening of the... Full description

Journal Title: Molecules (Basel Switzerland), March 14, 2011, Vol.16(3), pp.2414-2430
Main Author: Imramovsky, Ales
Other Authors: Pesko, Matus , Kralova, Katarina , Vejsova, Marcela , Stolarikova, Jirina , Vinsova, Jarmila , Jampilek, Josef
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1420-3049 ; DOI: 10.3390/molecules16032414
Link: http://search.proquest.com/docview/857291286/?pq-origsite=primo
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title: Investigating spectrum of biological activity of 4- and 5-chloro-2-hydroxy-N-[2-(arylamino)-1-alkyl-2-oxoethyl]benzamides.
format: Article
creator:
  • Imramovsky, Ales
  • Pesko, Matus
  • Kralova, Katarina
  • Vejsova, Marcela
  • Stolarikova, Jirina
  • Vinsova, Jarmila
  • Jampilek, Josef
subjects:
  • Anti-Bacterial Agents–Chemistry
  • Benzamides–Pharmacology
  • Chromatography, High Pressure Liquid–Chemistry
  • Electron Transport–Pharmacology
  • Microbial Sensitivity Tests–Drug Effects
  • Mycobacterium–Drug Effects
  • Anti-Bacterial Agents
  • Benzamides
ispartof: Molecules (Basel, Switzerland), March 14, 2011, Vol.16(3), pp.2414-2430
description: In this study, a series of twenty-two 5-chloro-2-hydroxy- N -[2-(arylamino)-1-alkyl-2-oxoethyl]benzamides and ten 4-chloro-2-hydroxy- N -[2-(arylamino)-1-alkyl-2-oxoethyl]benzamides is described. The compounds were analyzed using RP-HPLC to determine lipophilicity. Primary in vitro screening of the synthesized compounds was performed against mycobacterial, bacterial and fungal strains. They were also evaluated for their activity related to the inhibition of photosynthetic electron transport (PET) in spinach ( Spinacia oleracea L.) chloroplasts. The compounds showed biological activity comparable with or higher than the standards isoniazid, fluconazole, penicillin G or ciprofloxacin. For all the compounds, the relationships between the lipophilicity and the chemical structure of the studied compounds as well as their structure-activity relationships are discussed.
language: eng
source:
identifier: E-ISSN: 1420-3049 ; DOI: 10.3390/molecules16032414
fulltext: fulltext
issn:
  • 14203049
  • 1420-3049
url: Link


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titleInvestigating spectrum of biological activity of 4- and 5-chloro-2-hydroxy-N-[2-(arylamino)-1-alkyl-2-oxoethyl]benzamides.
creatorImramovsky, Ales ; Pesko, Matus ; Kralova, Katarina ; Vejsova, Marcela ; Stolarikova, Jirina ; Vinsova, Jarmila ; Jampilek, Josef
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identifierE-ISSN: 1420-3049 ; DOI: 10.3390/molecules16032414
subjectAnti-Bacterial Agents–Chemistry ; Benzamides–Pharmacology ; Chromatography, High Pressure Liquid–Chemistry ; Electron Transport–Pharmacology ; Microbial Sensitivity Tests–Drug Effects ; Mycobacterium–Drug Effects ; Anti-Bacterial Agents ; Benzamides
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descriptionIn this study, a series of twenty-two 5-chloro-2-hydroxy- N -[2-(arylamino)-1-alkyl-2-oxoethyl]benzamides and ten 4-chloro-2-hydroxy- N -[2-(arylamino)-1-alkyl-2-oxoethyl]benzamides is described. The compounds were analyzed using RP-HPLC to determine lipophilicity. Primary in vitro screening of the synthesized compounds was performed against mycobacterial, bacterial and fungal strains. They were also evaluated for their activity related to the inhibition of photosynthetic electron transport (PET) in spinach ( Spinacia oleracea L.) chloroplasts. The compounds showed biological activity comparable with or higher than the standards isoniazid, fluconazole, penicillin G or ciprofloxacin. For all the compounds, the relationships between the lipophilicity and the chemical structure of the studied compounds as well as their structure-activity relationships are discussed.
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