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Loss of NK stimulatory capacity by plasmacytoid and monocyte-derived DC but not myeloid DC in HIV-1 infected patients.

Dendritic cells (DC) are potent inducers of natural killer (NK) cells. There are two distinct populations in blood, myeloid (mDC) and plasmacytoid (pDC) but they can also be generated In vitro from monocytes (mdDC). Although it is established that blood DC are lost in HIV-1 infection, the full impac... Full description

Journal Title: PloS one March 8, 2011, Vol.6(3), p.e17525
Main Author: Benlahrech, Adel
Other Authors: Gotch, Frances , Kelleher, Peter , Patterson, Steven
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0017525
Link: http://search.proquest.com/docview/857484773/?pq-origsite=primo
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title: Loss of NK stimulatory capacity by plasmacytoid and monocyte-derived DC but not myeloid DC in HIV-1 infected patients.
format: Article
creator:
  • Benlahrech, Adel
  • Gotch, Frances
  • Kelleher, Peter
  • Patterson, Steven
subjects:
  • Adult–Drug Effects
  • Cell Count–Cytology
  • Cell Differentiation–Drug Effects
  • Coculture Techniques–Immunology
  • Cohort Studies–Complications
  • Dendritic Cells–Immunology
  • Female–Drug Effects
  • HIV Infections–Immunology
  • HIV-1–Metabolism
  • Humans–Drug Effects
  • Interferon-Gamma–Immunology
  • Killer Cells, Natural–Metabolism
  • Lipopolysaccharides–Pharmacology
  • Lymphocyte Activation–Drug Effects
  • Male–Immunology
  • Middle Aged–Cytology
  • Monocytes–Pharmacology
  • Oligodeoxyribonucleotides–Complications
  • Viremia–Immunology
  • Young Adult
ispartof: PloS one, March 8, 2011, Vol.6(3), p.e17525
description: Dendritic cells (DC) are potent inducers of natural killer (NK) cells. There are two distinct populations in blood, myeloid (mDC) and plasmacytoid (pDC) but they can also be generated In vitro from monocytes (mdDC). Although it is established that blood DC are lost in HIV-1 infection, the full impact of HIV-1 infection on DC-NK cell interactions remains elusive. We thus investigated the ability of pDC, mDC, and mdDC from viremic and anti-retroviral therapy-treated aviremic HIV-1+ patients to stimulate various NK cell functions. Stimulated pDC and mdDC from HIV-1+ patients showed reduced secretion of IFN-[alpha] and IL-12p70 respectively and their capacity to stimulate expression of CD25 and CD69, and IFN-[gamma] secretion in NK cells was also reduced. pDC activation of NK cell degranulation in response to a tumour cell line was severely reduced in HIV-1+ patients but the ability of mDC to activate NK cells was not affected by HIV-1 infection, with the exception of HLA-DR induction. No differences were observed between viremic and aviremic patients indicating that anti-retroviral therapy had minimal effect on restoration on pDC and mdDC-mediated activation of NK cells. Results from this study provide further insight into HIV-1 mediated suppression of innate immune functions.
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0017525
fulltext: fulltext
issn:
  • 19326203
  • 1932-6203
url: Link


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titleLoss of NK stimulatory capacity by plasmacytoid and monocyte-derived DC but not myeloid DC in HIV-1 infected patients.
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identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0017525
subjectAdult–Drug Effects ; Cell Count–Cytology ; Cell Differentiation–Drug Effects ; Coculture Techniques–Immunology ; Cohort Studies–Complications ; Dendritic Cells–Immunology ; Female–Drug Effects ; HIV Infections–Immunology ; HIV-1–Metabolism ; Humans–Drug Effects ; Interferon-Gamma–Immunology ; Killer Cells, Natural–Metabolism ; Lipopolysaccharides–Pharmacology ; Lymphocyte Activation–Drug Effects ; Male–Immunology ; Middle Aged–Cytology ; Monocytes–Pharmacology ; Oligodeoxyribonucleotides–Complications ; Viremia–Immunology ; Young Adult
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descriptionDendritic cells (DC) are potent inducers of natural killer (NK) cells. There are two distinct populations in blood, myeloid (mDC) and plasmacytoid (pDC) but they can also be generated In vitro from monocytes (mdDC). Although it is established that blood DC are lost in HIV-1 infection, the full impact of HIV-1 infection on DC-NK cell interactions remains elusive. We thus investigated the ability of pDC, mDC, and mdDC from viremic and anti-retroviral therapy-treated aviremic HIV-1+ patients to stimulate various NK cell functions. Stimulated pDC and mdDC from HIV-1+ patients showed reduced secretion of IFN-[alpha] and IL-12p70 respectively and their capacity to stimulate expression of CD25 and CD69, and IFN-[gamma] secretion in NK cells was also reduced. pDC activation of NK cell degranulation in response to a tumour cell line was severely reduced in HIV-1+ patients but the ability of mDC to activate NK cells was not affected by HIV-1 infection, with the exception of HLA-DR induction. No differences were observed between viremic and aviremic patients indicating that anti-retroviral therapy had minimal effect on restoration on pDC and mdDC-mediated activation of NK cells. Results from this study provide further insight into HIV-1 mediated suppression of innate immune functions.
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