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MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers

Chromosomal translocations are critically involved in the molecular pathogenesis of B-cell lymphomas, and highly recurrent and specific rearrangements have defined distinct molecular subtypes linked to unique clinicopathological features. In contrast, several well-characterized lymphoma entities sti... Full description

Journal Title: Nature Mar 17, 2011, Vol.471(7338), pp.377-81
Main Author: Steidl, Christian
Other Authors: Shah, Sohrab , Woolcock, Bruce , Rui, Lixin , Kawahara, Masahiro , Farinha, Pedro , Johnson, Nathalie , Zhao, Yongjun , Telenius, Adele , Neriah, Susana , Mcpherson, Andrew , Meissner, Barbara , Okoye, Ujunwa , Diepstra, Arjan , van Den Berg, Anke , Sun, Mark , Leung, Gillian , Jones, Steven , Connors, Joseph , Huntsman
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 00280836 ; E-ISSN: 14764687 ; DOI: 10.1038/nature09754
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title: MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers
format: Article
creator:
  • Steidl, Christian
  • Shah, Sohrab
  • Woolcock, Bruce
  • Rui, Lixin
  • Kawahara, Masahiro
  • Farinha, Pedro
  • Johnson, Nathalie
  • Zhao, Yongjun
  • Telenius, Adele
  • Neriah, Susana
  • Mcpherson, Andrew
  • Meissner, Barbara
  • Okoye, Ujunwa
  • Diepstra, Arjan
  • van Den Berg, Anke
  • Sun, Mark
  • Leung, Gillian
  • Jones, Steven
  • Connors, Joseph
  • Huntsman
subjects:
  • Antigens, CD–Genetics
  • Antigens, CD–Metabolism
  • Antigens, Cd274–Genetics
  • Antigens, Cd80–Metabolism
  • Antigens, Cd80–Genetics
  • Base Sequence–Genetics
  • Cell Line, Tumor–Genetics
  • Chromosome Breakpoints–Genetics
  • Gene Expression Profiling–Genetics
  • Gene Expression Regulation, Neoplastic–Immunology
  • Hodgkin Disease–Metabolism
  • Humans–Pathology
  • In Situ Hybridization, Fluorescence–Genetics
  • Jurkat Cells–Genetics
  • Lymphocyte Activation–Genetics
  • Lymphoma, B-Cell–Genetics
  • Molecular Sequence Data–Genetics
  • Nuclear Proteins–Genetics
  • Oncogene Proteins, Fusion–Genetics
  • Programmed Cell Death 1 Ligand 2 Protein
ispartof: Nature, Mar 17, 2011, Vol.471(7338), pp.377-81
description: Chromosomal translocations are critically involved in the molecular pathogenesis of B-cell lymphomas, and highly recurrent and specific rearrangements have defined distinct molecular subtypes linked to unique clinicopathological features. In contrast, several well-characterized lymphoma entities still lack disease-defining translocation events. To identify novel fusion transcripts resulting from translocations, we investigated two Hodgkin lymphoma cell lines by whole-transcriptome paired-end sequencing (RNA-seq). Here we show a highly expressed gene fusion involving the major histocompatibility complex (MHC) class II transactivator CIITA (MHC2TA) in KM-H2 cells. In a subsequent evaluation of 263 B-cell lymphomas, we also demonstrate that genomic CIITA breaks are highly recurrent in primary mediastinal B-cell lymphoma (38%) and classical Hodgkin lymphoma (cHL) (15%). Furthermore, we find that CIITA is a promiscuous partner of various in-frame gene fusions, and we report that CIITA gene alterations...
language: eng
source:
identifier: ISSN: 00280836 ; E-ISSN: 14764687 ; DOI: 10.1038/nature09754
fulltext: fulltext
issn:
  • 00280836
  • 0028-0836
  • 14764687
  • 1476-4687
url: Link


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titleMHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers
creatorSteidl, Christian ; Shah, Sohrab ; Woolcock, Bruce ; Rui, Lixin ; Kawahara, Masahiro ; Farinha, Pedro ; Johnson, Nathalie ; Zhao, Yongjun ; Telenius, Adele ; Neriah, Susana ; Mcpherson, Andrew ; Meissner, Barbara ; Okoye, Ujunwa ; Diepstra, Arjan ; van Den Berg, Anke ; Sun, Mark ; Leung, Gillian ; Jones, Steven ; Connors, Joseph ; Huntsman
ispartofNature, Mar 17, 2011, Vol.471(7338), pp.377-81
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subjectAntigens, CD–Genetics ; Antigens, CD–Metabolism ; Antigens, Cd274–Genetics ; Antigens, Cd80–Metabolism ; Antigens, Cd80–Genetics ; Base Sequence–Genetics ; Cell Line, Tumor–Genetics ; Chromosome Breakpoints–Genetics ; Gene Expression Profiling–Genetics ; Gene Expression Regulation, Neoplastic–Immunology ; Hodgkin Disease–Metabolism ; Humans–Pathology ; In Situ Hybridization, Fluorescence–Genetics ; Jurkat Cells–Genetics ; Lymphocyte Activation–Genetics ; Lymphoma, B-Cell–Genetics ; Molecular Sequence Data–Genetics ; Nuclear Proteins–Genetics ; Oncogene Proteins, Fusion–Genetics ; Programmed Cell Death 1 Ligand 2 Protein
descriptionChromosomal translocations are critically involved in the molecular pathogenesis of B-cell lymphomas, and highly recurrent and specific rearrangements have defined distinct molecular subtypes linked to unique clinicopathological features. In contrast, several well-characterized lymphoma entities still lack disease-defining translocation events. To identify novel fusion transcripts resulting from translocations, we investigated two Hodgkin lymphoma cell lines by whole-transcriptome paired-end sequencing (RNA-seq). Here we show a highly expressed gene fusion involving the major histocompatibility complex (MHC) class II transactivator CIITA (MHC2TA) in KM-H2 cells. In a subsequent evaluation of 263 B-cell lymphomas, we also demonstrate that genomic CIITA breaks are highly recurrent in primary mediastinal B-cell lymphoma (38%) and classical Hodgkin lymphoma (cHL) (15%). Furthermore, we find that CIITA is a promiscuous partner of various in-frame gene fusions, and we report that CIITA gene alterations...
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titleMHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers
descriptionChromosomal translocations are critically involved in the molecular pathogenesis of B-cell lymphomas, and highly recurrent and specific rearrangements have defined distinct molecular subtypes linked to unique clinicopathological features. In contrast, several well-characterized lymphoma entities still lack disease-defining translocation events. To identify novel fusion transcripts resulting from translocations, we investigated two Hodgkin lymphoma cell lines by whole-transcriptome paired-end sequencing (RNA-seq). Here we show a highly expressed gene fusion involving the major histocompatibility complex (MHC) class II transactivator CIITA (MHC2TA) in KM-H2 cells. In a subsequent evaluation of 263 B-cell lymphomas, we also demonstrate that genomic CIITA breaks are highly recurrent in primary mediastinal B-cell lymphoma (38%) and classical Hodgkin lymphoma (cHL) (15%). Furthermore, we find that CIITA is a promiscuous partner of various in-frame gene fusions, and we report that CIITA gene alterations...
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citationpf 377 pt 81 vol 471 issue 7338
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titleMHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers
authorSteidl, Christian ; Shah, Sohrab ; Woolcock, Bruce ; Rui, Lixin ; Kawahara, Masahiro ; Farinha, Pedro ; Johnson, Nathalie ; Zhao, Yongjun ; Telenius, Adele ; Neriah, Susana ; Mcpherson, Andrew ; Meissner, Barbara ; Okoye, Ujunwa ; Diepstra, Arjan ; van Den Berg, Anke ; Sun, Mark ; Leung, Gillian ; Jones, Steven ; Connors, Joseph ; Huntsman
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0Antigens, CD–Genetics
1Antigens, CD–Metabolism
2Antigens, Cd274–Genetics
3Antigens, Cd80–Metabolism
4Antigens, Cd80–Genetics
5Base Sequence–Genetics
6Cell Line, Tumor–Genetics
7Chromosome Breakpoints–Genetics
8Gene Expression Profiling–Genetics
9Gene Expression Regulation, Neoplastic–Immunology
10Hodgkin Disease–Metabolism
11Humans–Pathology
12In Situ Hybridization, Fluorescence–Genetics
13Jurkat Cells–Genetics
14Lymphocyte Activation–Genetics
15Lymphoma, B-Cell–Genetics
16Molecular Sequence Data–Genetics
17Nuclear Proteins–Genetics
18Oncogene Proteins, Fusion–Genetics
19Programmed Cell Death 1 Ligand 2 Protein
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abstractChromosomal translocations are critically involved in the molecular pathogenesis of B-cell lymphomas, and highly recurrent and specific rearrangements have defined distinct molecular subtypes linked to unique clinicopathological features. In contrast, several well-characterized lymphoma entities still lack disease-defining translocation events. To identify novel fusion transcripts resulting from translocations, we investigated two Hodgkin lymphoma cell lines by whole-transcriptome paired-end sequencing (RNA-seq). Here we show a highly expressed gene fusion involving the major histocompatibility complex (MHC) class II transactivator CIITA (MHC2TA) in KM-H2 cells. In a subsequent evaluation of 263 B-cell lymphomas, we also demonstrate that genomic CIITA breaks are highly recurrent in primary mediastinal B-cell lymphoma (38%) and classical Hodgkin lymphoma (cHL) (15%). Furthermore, we find that CIITA is a promiscuous partner of various in-frame gene fusions, and we report that CIITA gene alterations...
copLondon
pubNature Publishing Group
doi10.1038/nature09754
urlhttp://search.proquest.com/docview/858373090/
date2011-03-17