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A novel peptide probe for imaging and targeted delivery of liposomal doxorubicin to lung tumor.

Targeted delivery of imaging agents and therapeutics to tumors would provide early detection and increased therapeutic efficacy against cancer. Here we have screened a phage-displayed peptide library to identify peptides that selectively bind to lung tumor cells. Evaluation of individual phage clone... Full description

Journal Title: Molecular pharmaceutics April 4, 2011, Vol.8(2), pp.430-438
Main Author: He, Xiaofeng
Other Authors: Na, Moon-Hee , Kim, Jin-Sook , Lee, Ga-Young , Park, Jae Yong , Hoffman, Allan S , Nam, Ju-Ock , Han, Su-Eun , Sim, Ga Yong , Oh, Yu-Kyoung , Kim, In-San , Lee, Byung-Heon
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1543-8392 ; DOI: 10.1021/mp100266g
Link: http://search.proquest.com/docview/860186286/?pq-origsite=primo
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recordid: proquest860186286
title: A novel peptide probe for imaging and targeted delivery of liposomal doxorubicin to lung tumor.
format: Article
creator:
  • He, Xiaofeng
  • Na, Moon-Hee
  • Kim, Jin-Sook
  • Lee, Ga-Young
  • Park, Jae Yong
  • Hoffman, Allan S
  • Nam, Ju-Ock
  • Han, Su-Eun
  • Sim, Ga Yong
  • Oh, Yu-Kyoung
  • Kim, In-San
  • Lee, Byung-Heon
subjects:
  • Animals–Administration & Dosage
  • Antibiotics, Antineoplastic–Pharmacokinetics
  • Apoptosis–Pharmacology
  • Blotting, Western–Drug Effects
  • Doxorubicin–Administration & Dosage
  • Drug Delivery Systems–Pharmacokinetics
  • Enzyme-Linked Immunosorbent Assay–Pharmacology
  • Female–Drug Therapy
  • Flow Cytometry–Pathology
  • Fluorescent Antibody Technique–Administration & Dosage
  • Image Processing, Computer-Assisted–Pharmacokinetics
  • Immunoenzyme Techniques–Pharmacokinetics
  • Liposomes–Pharmacokinetics
  • Lung Neoplasms–Pharmacokinetics
  • Mice–Pharmacokinetics
  • Mice, Inbred Balb C–Pharmacokinetics
  • Mice, Nude–Pharmacokinetics
  • Peptide Fragments–Pharmacokinetics
  • Peptide Library–Pharmacokinetics
  • Tissue Distribution–Pharmacokinetics
  • Tumor Cells, Cultured–Pharmacokinetics
  • Antibiotics, Antineoplastic
  • Liposomes
  • Peptide Fragments
  • Peptide Library
  • Doxorubicin
ispartof: Molecular pharmaceutics, April 4, 2011, Vol.8(2), pp.430-438
description: Targeted delivery of imaging agents and therapeutics to tumors would provide early detection and increased therapeutic efficacy against cancer. Here we have screened a phage-displayed peptide library to identify peptides that selectively bind to lung tumor cells. Evaluation of individual phage clones after screening revealed that a phage clone displaying the CSNIDARAC peptide bound to H460 lung tumor cells at higher extent than other phage clones. The synthetic CSNIDARAC peptide strongly bound to H460 cells and was efficiently internalized into the cells, while little binding of a control peptide was seen. It also preferentially bound to other lung tumor cell lines as compared to cells of different tumor types. In vivo imaging of lung tumor was achieved by homing of fluorescence dye-labeled CSNIDARAC peptide to the tumor after intravenous injection into mice. Ex vivo imaging and microscopic analysis of isolated organs further demonstrated the targeting of CSNIDARAC peptide to tumor. The...
language: eng
source:
identifier: E-ISSN: 1543-8392 ; DOI: 10.1021/mp100266g
fulltext: fulltext
issn:
  • 15438392
  • 1543-8392
url: Link


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titleA novel peptide probe for imaging and targeted delivery of liposomal doxorubicin to lung tumor.
creatorHe, Xiaofeng ; Na, Moon-Hee ; Kim, Jin-Sook ; Lee, Ga-Young ; Park, Jae Yong ; Hoffman, Allan S ; Nam, Ju-Ock ; Han, Su-Eun ; Sim, Ga Yong ; Oh, Yu-Kyoung ; Kim, In-San ; Lee, Byung-Heon
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ispartofMolecular pharmaceutics, April 4, 2011, Vol.8(2), pp.430-438
identifierE-ISSN: 1543-8392 ; DOI: 10.1021/mp100266g
subjectAnimals–Administration & Dosage ; Antibiotics, Antineoplastic–Pharmacokinetics ; Apoptosis–Pharmacology ; Blotting, Western–Drug Effects ; Doxorubicin–Administration & Dosage ; Drug Delivery Systems–Pharmacokinetics ; Enzyme-Linked Immunosorbent Assay–Pharmacology ; Female–Drug Therapy ; Flow Cytometry–Pathology ; Fluorescent Antibody Technique–Administration & Dosage ; Image Processing, Computer-Assisted–Pharmacokinetics ; Immunoenzyme Techniques–Pharmacokinetics ; Liposomes–Pharmacokinetics ; Lung Neoplasms–Pharmacokinetics ; Mice–Pharmacokinetics ; Mice, Inbred Balb C–Pharmacokinetics ; Mice, Nude–Pharmacokinetics ; Peptide Fragments–Pharmacokinetics ; Peptide Library–Pharmacokinetics ; Tissue Distribution–Pharmacokinetics ; Tumor Cells, Cultured–Pharmacokinetics ; Antibiotics, Antineoplastic ; Liposomes ; Peptide Fragments ; Peptide Library ; Doxorubicin
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descriptionTargeted delivery of imaging agents and therapeutics to tumors would provide early detection and increased therapeutic efficacy against cancer. Here we have screened a phage-displayed peptide library to identify peptides that selectively bind to lung tumor cells. Evaluation of individual phage clones after screening revealed that a phage clone displaying the CSNIDARAC peptide bound to H460 lung tumor cells at higher extent than other phage clones. The synthetic CSNIDARAC peptide strongly bound to H460 cells and was efficiently internalized into the cells, while little binding of a control peptide was seen. It also preferentially bound to other lung tumor cell lines as compared to cells of different tumor types. In vivo imaging of lung tumor was achieved by homing of fluorescence dye-labeled CSNIDARAC peptide to the tumor after intravenous injection into mice. Ex vivo imaging and microscopic analysis of isolated organs further demonstrated the targeting of CSNIDARAC peptide to tumor. The...
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titleA novel peptide probe for imaging and targeted delivery of liposomal doxorubicin to lung tumor.
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titleA novel peptide probe for imaging and targeted delivery of liposomal doxorubicin to lung tumor.
authorHe, Xiaofeng ; Na, Moon-Hee ; Kim, Jin-Sook ; Lee, Ga-Young ; Park, Jae Yong ; Hoffman, Allan S ; Nam, Ju-Ock ; Han, Su-Eun ; Sim, Ga Yong ; Oh, Yu-Kyoung ; Kim, In-San ; Lee, Byung-Heon
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6Enzyme-Linked Immunosorbent Assay–Pharmacology
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