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Non-apoptotic role of BID in inflammation and innate immunity

Innate immunity is a fundamental defence response that depends on evolutionarily conserved pattern recognition receptors for sensing infections or danger signals. Nucleotide-binding and oligomerization domain (NOD) proteins are cytosolic pattern-recognition receptors of paramount importance in the i... Full description

Journal Title: Nature Jun 2, 2011, Vol.474(7349), pp.96-9
Main Author: Yeretssian, Garabet
Other Authors: Correa, Ricardo , Doiron, Karine , Fitzgerald, Patrick , Dillon, Christopher , Green, Douglas , Reed, John , Saleh, Maya
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 00280836 ; E-ISSN: 14764687 ; DOI: 10.1038/nature09982
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recordid: proquest872024761
title: Non-apoptotic role of BID in inflammation and innate immunity
format: Article
creator:
  • Yeretssian, Garabet
  • Correa, Ricardo
  • Doiron, Karine
  • Fitzgerald, Patrick
  • Dillon, Christopher
  • Green, Douglas
  • Reed, John
  • Saleh, Maya
subjects:
  • Animals–Immunology
  • Apoptosis–Genetics
  • Bh3 Interacting Domain Death Agonist Protein–Immunology
  • Bh3 Interacting Domain Death Agonist Protein–Genetics
  • Colitis–Immunology
  • Colitis–Immunology
  • Epithelial Cells–Immunology
  • Hek293 Cells–Genetics
  • Ht29 Cells–Genetics
  • Humans–Immunology
  • I-Kappa B Kinase–Immunology
  • Immunity, Innate–Immunology
  • Inflammation–Genetics
  • Intestinal Mucosa–Immunology
  • Mice–Immunology
  • Mice, Inbred C57bl–Immunology
  • Nod1 Signaling Adaptor Protein–Immunology
  • Nod2 Signaling Adaptor Protein–Immunology
  • RNA Interference–Immunology
  • Signal Transduction
ispartof: Nature, Jun 2, 2011, Vol.474(7349), pp.96-9
description: Innate immunity is a fundamental defence response that depends on evolutionarily conserved pattern recognition receptors for sensing infections or danger signals. Nucleotide-binding and oligomerization domain (NOD) proteins are cytosolic pattern-recognition receptors of paramount importance in the intestine, and their dysregulation is associated with inflammatory bowel disease. They sense peptidoglycans from commensal microorganisms and pathogens and coordinate signalling events that culminate in the induction of inflammation and anti-microbial responses. However, the signalling mechanisms involved in this process are not fully understood. Here, using genome-wide RNA interference, we identify candidate genes that modulate the NOD1 inflammatory response in intestinal epithelial cells. Our results reveal a significant crosstalk between innate immunity and apoptosis and identify BID, a BCL2 family protein, as a critical component of the inflammatory response. Colonocytes depleted of BID or...
language: eng
source:
identifier: ISSN: 00280836 ; E-ISSN: 14764687 ; DOI: 10.1038/nature09982
fulltext: fulltext
issn:
  • 00280836
  • 0028-0836
  • 14764687
  • 1476-4687
url: Link


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titleNon-apoptotic role of BID in inflammation and innate immunity
creatorYeretssian, Garabet ; Correa, Ricardo ; Doiron, Karine ; Fitzgerald, Patrick ; Dillon, Christopher ; Green, Douglas ; Reed, John ; Saleh, Maya
ispartofNature, Jun 2, 2011, Vol.474(7349), pp.96-9
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subjectAnimals–Immunology ; Apoptosis–Genetics ; Bh3 Interacting Domain Death Agonist Protein–Immunology ; Bh3 Interacting Domain Death Agonist Protein–Genetics ; Colitis–Immunology ; Colitis–Immunology ; Epithelial Cells–Immunology ; Hek293 Cells–Genetics ; Ht29 Cells–Genetics ; Humans–Immunology ; I-Kappa B Kinase–Immunology ; Immunity, Innate–Immunology ; Inflammation–Genetics ; Intestinal Mucosa–Immunology ; Mice–Immunology ; Mice, Inbred C57bl–Immunology ; Nod1 Signaling Adaptor Protein–Immunology ; Nod2 Signaling Adaptor Protein–Immunology ; RNA Interference–Immunology ; Signal Transduction
descriptionInnate immunity is a fundamental defence response that depends on evolutionarily conserved pattern recognition receptors for sensing infections or danger signals. Nucleotide-binding and oligomerization domain (NOD) proteins are cytosolic pattern-recognition receptors of paramount importance in the intestine, and their dysregulation is associated with inflammatory bowel disease. They sense peptidoglycans from commensal microorganisms and pathogens and coordinate signalling events that culminate in the induction of inflammation and anti-microbial responses. However, the signalling mechanisms involved in this process are not fully understood. Here, using genome-wide RNA interference, we identify candidate genes that modulate the NOD1 inflammatory response in intestinal epithelial cells. Our results reveal a significant crosstalk between innate immunity and apoptosis and identify BID, a BCL2 family protein, as a critical component of the inflammatory response. Colonocytes depleted of BID or...
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titleNon-apoptotic role of BID in inflammation and innate immunity
descriptionInnate immunity is a fundamental defence response that depends on evolutionarily conserved pattern recognition receptors for sensing infections or danger signals. Nucleotide-binding and oligomerization domain (NOD) proteins are cytosolic pattern-recognition receptors of paramount importance in the intestine, and their dysregulation is associated with inflammatory bowel disease. They sense peptidoglycans from commensal microorganisms and pathogens and coordinate signalling events that culminate in the induction of inflammation and anti-microbial responses. However, the signalling mechanisms involved in this process are not fully understood. Here, using genome-wide RNA interference, we identify candidate genes that modulate the NOD1 inflammatory response in intestinal epithelial cells. Our results reveal a significant crosstalk between innate immunity and apoptosis and identify BID, a BCL2 family protein, as a critical component of the inflammatory response. Colonocytes depleted of BID or...
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titleNon-apoptotic role of BID in inflammation and innate immunity
authorYeretssian, Garabet ; Correa, Ricardo ; Doiron, Karine ; Fitzgerald, Patrick ; Dillon, Christopher ; Green, Douglas ; Reed, John ; Saleh, Maya
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abstractInnate immunity is a fundamental defence response that depends on evolutionarily conserved pattern recognition receptors for sensing infections or danger signals. Nucleotide-binding and oligomerization domain (NOD) proteins are cytosolic pattern-recognition receptors of paramount importance in the intestine, and their dysregulation is associated with inflammatory bowel disease. They sense peptidoglycans from commensal microorganisms and pathogens and coordinate signalling events that culminate in the induction of inflammation and anti-microbial responses. However, the signalling mechanisms involved in this process are not fully understood. Here, using genome-wide RNA interference, we identify candidate genes that modulate the NOD1 inflammatory response in intestinal epithelial cells. Our results reveal a significant crosstalk between innate immunity and apoptosis and identify BID, a BCL2 family protein, as a critical component of the inflammatory response. Colonocytes depleted of BID or...
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pubNature Publishing Group
doi10.1038/nature09982
urlhttp://search.proquest.com/docview/872024761/
date2011-06-02