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Characteristics and PD-1 expression of peripheral CD4+CD127loCD25hiFoxP3+ Treg cells in chronic HCV infected-patients.

BACKGROUNDBoth regulatory T cells (Tregs) and PD-1/PD-L1 pathway were critically involved in HCV viral persistence. However, the association between them was not well investigated. Herein, we aimed to investigate the distributional profiles of Tregs subsets and association between PD-1 expression on... Full description

Journal Title: Virology journal June 7, 2011, Vol.8, p.279
Main Author: Shen, Tao
Other Authors: Zheng, Jiajia , Liang, Hua , Xu, Chunhui , Chen, Xiangmei , Zhang, Ting , Xu, Qiang , Lu, Fengmin
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1743-422X ; DOI: 10.1186/1743-422X-8-279
Link: http://search.proquest.com/docview/875091808/?pq-origsite=primo
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title: Characteristics and PD-1 expression of peripheral CD4+CD127loCD25hiFoxP3+ Treg cells in chronic HCV infected-patients.
format: Article
creator:
  • Shen, Tao
  • Zheng, Jiajia
  • Liang, Hua
  • Xu, Chunhui
  • Chen, Xiangmei
  • Zhang, Ting
  • Xu, Qiang
  • Lu, Fengmin
subjects:
  • Adult–Biosynthesis
  • Antigens, CD–Biosynthesis
  • Apoptosis Regulatory Proteins–Analysis
  • Cd4 Antigens–Analysis
  • Female–Immunology
  • Flow Cytometry–Analysis
  • Forkhead Transcription Factors–Analysis
  • Gene Expression Profiling–Analysis
  • Hepatitis C, Chronic–Chemistry
  • Humans–Immunology
  • Interleukin-2 Receptor Alpha Subunit–Chemistry
  • Interleukin-7 Receptor Alpha Subunit–Immunology
  • Leukocyte Common Antigens–Immunology
  • Male–Immunology
  • Middle Aged–Immunology
  • Programmed Cell Death 1 Receptor–Immunology
  • T-Lymphocyte Subsets–Immunology
  • T-Lymphocytes, Regulatory–Immunology
  • Antigens, CD
  • Apoptosis Regulatory Proteins
ispartof: Virology journal, June 7, 2011, Vol.8, p.279
description: BACKGROUNDBoth regulatory T cells (Tregs) and PD-1/PD-L1 pathway were critically involved in HCV viral persistence. However, the association between them was not well investigated. Herein, we aimed to investigate the distributional profiles of Tregs subsets and association between PD-1 expression on these subsets and development of HCV long-term persistence. METHODSCD45RA and CD27 were employed to separate peripheral Tregs as naïve/central memory/effector memory/effector subsets. The phenotypic characteristics and PD-1 expression of Tregs were studied by flow cytometry. RESULTSIn the present study, the majority of Tregs was identified as central memory phenotype in chronic hepatitis C patients compared with nearly equal contribution of naïve and central memory subsets in healthy individuals. PD-1 expression was elevated in all CD4+ T cell subset in chronic HCV infected patients, including Tregs. Of note, higher level of PD-1 expression was found on TEM- and effector-Treg than naïve- and...
language: eng
source:
identifier: E-ISSN: 1743-422X ; DOI: 10.1186/1743-422X-8-279
fulltext: fulltext
issn:
  • 1743422X
  • 1743-422X
url: Link


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titleCharacteristics and PD-1 expression of peripheral CD4+CD127loCD25hiFoxP3+ Treg cells in chronic HCV infected-patients.
creatorShen, Tao ; Zheng, Jiajia ; Liang, Hua ; Xu, Chunhui ; Chen, Xiangmei ; Zhang, Ting ; Xu, Qiang ; Lu, Fengmin
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ispartofVirology journal, June 7, 2011, Vol.8, p.279
identifierE-ISSN: 1743-422X ; DOI: 10.1186/1743-422X-8-279
subjectAdult–Biosynthesis ; Antigens, CD–Biosynthesis ; Apoptosis Regulatory Proteins–Analysis ; Cd4 Antigens–Analysis ; Female–Immunology ; Flow Cytometry–Analysis ; Forkhead Transcription Factors–Analysis ; Gene Expression Profiling–Analysis ; Hepatitis C, Chronic–Chemistry ; Humans–Immunology ; Interleukin-2 Receptor Alpha Subunit–Chemistry ; Interleukin-7 Receptor Alpha Subunit–Immunology ; Leukocyte Common Antigens–Immunology ; Male–Immunology ; Middle Aged–Immunology ; Programmed Cell Death 1 Receptor–Immunology ; T-Lymphocyte Subsets–Immunology ; T-Lymphocytes, Regulatory–Immunology ; Antigens, CD ; Apoptosis Regulatory Proteins
descriptionBACKGROUNDBoth regulatory T cells (Tregs) and PD-1/PD-L1 pathway were critically involved in HCV viral persistence. However, the association between them was not well investigated. Herein, we aimed to investigate the distributional profiles of Tregs subsets and association between PD-1 expression on these subsets and development of HCV long-term persistence. METHODSCD45RA and CD27 were employed to separate peripheral Tregs as naïve/central memory/effector memory/effector subsets. The phenotypic characteristics and PD-1 expression of Tregs were studied by flow cytometry. RESULTSIn the present study, the majority of Tregs was identified as central memory phenotype in chronic hepatitis C patients compared with nearly equal contribution of naïve and central memory subsets in healthy individuals. PD-1 expression was elevated in all CD4+ T cell subset in chronic HCV infected patients, including Tregs. Of note, higher level of PD-1 expression was found on TEM- and effector-Treg than naïve- and...
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titleCharacteristics and PD-1 expression of peripheral CD4+CD127loCD25hiFoxP3+ Treg cells in chronic HCV infected-patients.
descriptionBACKGROUNDBoth regulatory T cells (Tregs) and PD-1/PD-L1 pathway were critically involved in HCV viral persistence. However, the association between them was not well investigated. Herein, we aimed to investigate the distributional profiles of Tregs subsets and association between PD-1 expression on these subsets and development of HCV long-term persistence. METHODSCD45RA and CD27 were employed to separate peripheral Tregs as naïve/central memory/effector memory/effector subsets. The phenotypic characteristics and PD-1 expression of Tregs were studied by flow cytometry. RESULTSIn the present study, the majority of Tregs was identified as central memory phenotype in chronic hepatitis C patients compared with nearly equal contribution of naïve and central memory subsets in healthy individuals. PD-1 expression was elevated in all CD4+ T cell subset in chronic HCV infected patients, including Tregs. Of note, higher level of PD-1 expression was found on TEM- and effector-Treg than naïve- and...
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titleCharacteristics and PD-1 expression of peripheral CD4+CD127loCD25hiFoxP3+ Treg cells in chronic HCV infected-patients.
authorShen, Tao ; Zheng, Jiajia ; Liang, Hua ; Xu, Chunhui ; Chen, Xiangmei ; Zhang, Ting ; Xu, Qiang ; Lu, Fengmin
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abstractBACKGROUNDBoth regulatory T cells (Tregs) and PD-1/PD-L1 pathway were critically involved in HCV viral persistence. However, the association between them was not well investigated. Herein, we aimed to investigate the distributional profiles of Tregs subsets and association between PD-1 expression on these subsets and development of HCV long-term persistence. METHODSCD45RA and CD27 were employed to separate peripheral Tregs as naïve/central memory/effector memory/effector subsets. The phenotypic characteristics and PD-1 expression of Tregs were studied by flow cytometry. RESULTSIn the present study, the majority of Tregs was identified as central memory phenotype in chronic hepatitis C patients compared with nearly equal contribution of naïve and central memory subsets in healthy individuals. PD-1 expression was elevated in all CD4+ T cell subset in chronic HCV infected patients, including Tregs. Of note, higher level of PD-1 expression was found on TEM- and effector-Treg than naïve- and...
doi10.1186/1743-422X-8-279
urlhttp://search.proquest.com/docview/875091808/
issue1
date2011-06-07