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Archaeosomes with encapsulated antigens for oral vaccine delivery.

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.vaccine.2011.05.015 Byline: Zhengrong Li (a), Lihui Zhang (b), Wenqiang Sun (b), Qian Ding (b), Yongtai Hou (b), Yuhong Xu (b) Keywords: Archaeosomes; Liposomes; Oral delivery; Vaccine Abstract: Traditional ph... Full description

Journal Title: Vaccine July 18, 2011, Vol.29(32), pp.5260-5266
Main Author: Li, Zhengrong
Other Authors: Zhang, Lihui , Sun, Wenqiang , Ding, Qian , Hou, Yongtai , Xu, Yuhong
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1873-2518 ; DOI: 1873-2518 ; DOI: 10.1016/j.vaccine.2011.05.015
Link: http://search.proquest.com/docview/878031932/?pq-origsite=primo
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title: Archaeosomes with encapsulated antigens for oral vaccine delivery.
format: Article
creator:
  • Li, Zhengrong
  • Zhang, Lihui
  • Sun, Wenqiang
  • Ding, Qian
  • Hou, Yongtai
  • Xu, Yuhong
subjects:
  • Adjuvants, Immunologic–Administration & Dosage
  • Administration, Oral–Immunology
  • Animals–Immunology
  • Antigens–Immunology
  • Cd8-Positive T-Lymphocytes–Immunology
  • Drug Delivery Systems–Immunology
  • Enzyme-Linked Immunosorbent Assay–Administration & Dosage
  • Female–Immunology
  • Gastrointestinal Tract–Administration & Dosage
  • Immunoglobulin A–Immunology
  • Immunoglobulin G–Immunology
  • Lipids–Administration & Dosage
  • Liposomes–Immunology
  • Mice–Immunology
  • Mice, Inbred Balb C–Immunology
  • Ovalbumin–Immunology
  • Sulfolobus Acidocaldarius–Immunology
  • Vaccines–Immunology
  • Adjuvants, Immunologic
  • Antigens
  • Immunoglobulin A
  • Immunoglobulin G
  • Lipids
  • Liposomes
  • Vaccines
  • Ovalbumin
ispartof: Vaccine, July 18, 2011, Vol.29(32), pp.5260-5266
description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.vaccine.2011.05.015 Byline: Zhengrong Li (a), Lihui Zhang (b), Wenqiang Sun (b), Qian Ding (b), Yongtai Hou (b), Yuhong Xu (b) Keywords: Archaeosomes; Liposomes; Oral delivery; Vaccine Abstract: Traditional phosphodiester lipid vesicles (liposomes) are not stable and could be easily degraded in the gastrointestinal (GI) tract. We prepared a novel lipid based oral delivery system: archaeosomes, made of the polar lipid fraction E (PLFE) extracted from Sulfolobus acidocaldarius, and tested their immunogenic potentials as oral vaccine delivery vehicles. Our study showed that the archaeosomes had significant superior stability in simulated gastric and intestinal fluids, and would help fluorescent labeled antigens to reside longer time in the GI tract after oral administration. The resulted immune responses against model antigen ovalbumin (OVA) were greatly improved, eliciting substantial IgG response systemically as well as IgA response mucosally. In addition, the archaeosomes also facilitated antigen specific CD8.sup.+ T cell proliferation. These data indicate that archaeosomes may be a potential vaccine carrier and adjuvant for effective oral immunization. Author Affiliation: (a) Department of Cell Biology, Nanjing Medical University, Nanjing 210029, PR China (b) School of Pharmacy, Shanghai Jiao Tong University, 800 Dong Chuan Road, Shanghai 200240, PR China Article History: Received 8 October 2009; Revised 19 March 2011; Accepted 9 May 2011
language: eng
source:
identifier: E-ISSN: 1873-2518 ; DOI: 1873-2518 ; DOI: 10.1016/j.vaccine.2011.05.015
fulltext: fulltext
issn:
  • 18732518
  • 1873-2518
url: Link


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titleArchaeosomes with encapsulated antigens for oral vaccine delivery.
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subjectAdjuvants, Immunologic–Administration & Dosage ; Administration, Oral–Immunology ; Animals–Immunology ; Antigens–Immunology ; Cd8-Positive T-Lymphocytes–Immunology ; Drug Delivery Systems–Immunology ; Enzyme-Linked Immunosorbent Assay–Administration & Dosage ; Female–Immunology ; Gastrointestinal Tract–Administration & Dosage ; Immunoglobulin A–Immunology ; Immunoglobulin G–Immunology ; Lipids–Administration & Dosage ; Liposomes–Immunology ; Mice–Immunology ; Mice, Inbred Balb C–Immunology ; Ovalbumin–Immunology ; Sulfolobus Acidocaldarius–Immunology ; Vaccines–Immunology ; Adjuvants, Immunologic ; Antigens ; Immunoglobulin A ; Immunoglobulin G ; Lipids ; Liposomes ; Vaccines ; Ovalbumin
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descriptionTo link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.vaccine.2011.05.015 Byline: Zhengrong Li (a), Lihui Zhang (b), Wenqiang Sun (b), Qian Ding (b), Yongtai Hou (b), Yuhong Xu (b) Keywords: Archaeosomes; Liposomes; Oral delivery; Vaccine Abstract: Traditional phosphodiester lipid vesicles (liposomes) are not stable and could be easily degraded in the gastrointestinal (GI) tract. We prepared a novel lipid based oral delivery system: archaeosomes, made of the polar lipid fraction E (PLFE) extracted from Sulfolobus acidocaldarius, and tested their immunogenic potentials as oral vaccine delivery vehicles. Our study showed that the archaeosomes had significant superior stability in simulated gastric and intestinal fluids, and would help fluorescent labeled antigens to reside longer time in the GI tract after oral administration. The resulted immune responses against model antigen ovalbumin (OVA) were greatly improved, eliciting substantial IgG response systemically as well as IgA response mucosally. In addition, the archaeosomes also facilitated antigen specific CD8.sup.+ T cell proliferation. These data indicate that archaeosomes may be a potential vaccine carrier and adjuvant for effective oral immunization. Author Affiliation: (a) Department of Cell Biology, Nanjing Medical University, Nanjing 210029, PR China (b) School of Pharmacy, Shanghai Jiao Tong University, 800 Dong Chuan Road, Shanghai 200240, PR China Article History: Received 8 October 2009; Revised 19 March 2011; Accepted 9 May 2011
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authorLi, Zhengrong ; Zhang, Lihui ; Sun, Wenqiang ; Ding, Qian ; Hou, Yongtai ; Xu, Yuhong
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10Immunoglobulin G–Immunology
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