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Circulating long-chain ω-3 fatty acids and incidence of congestive heart failure in older adults: the cardiovascular health study: a cohort study.

BACKGROUNDFew previous studies have evaluated associations between long-chain ω-3 fatty acids and incidence of congestive heart failure (CHF), and those that have are typically based on diet questionnaires and yield conflicting results. Circulating fatty acid concentrations provide objective biomark... Full description

Journal Title: Annals of internal medicine August 2, 2011, Vol.155(3), pp.160-170
Main Author: Mozaffarian, Dariush
Other Authors: Lemaitre, Rozenn N , King, Irena B , Song, Xiaoling , Spiegelman, Donna , Sacks, Frank M , Rimm, Eric B , Siscovick, David S
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1539-3704 ; DOI: 10.7326/0003-4819-155-3-201108020-00006
Link: http://search.proquest.com/docview/881086512/?pq-origsite=primo
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title: Circulating long-chain ω-3 fatty acids and incidence of congestive heart failure in older adults: the cardiovascular health study: a cohort study.
format: Article
creator:
  • Mozaffarian, Dariush
  • Lemaitre, Rozenn N
  • King, Irena B
  • Song, Xiaoling
  • Spiegelman, Donna
  • Sacks, Frank M
  • Rimm, Eric B
  • Siscovick, David S
subjects:
  • Aged–Blood
  • Biomarkers–Blood
  • Docosahexaenoic Acids–Blood
  • Eicosapentaenoic Acid–Blood
  • Fatty Acids, Omega-3–Blood
  • Fatty Acids, Unsaturated–Blood
  • Feeding Behavior–Epidemiology
  • Heart Failure–Epidemiology
  • Humans–Epidemiology
  • Incidence–Epidemiology
  • Proportional Hazards Models–Epidemiology
  • Prospective Studies–Epidemiology
  • Risk Factors–Epidemiology
  • Abridged
  • Biomarkers
  • Fatty Acids, Omega-3
  • Fatty Acids, Unsaturated
  • Docosahexaenoic Acids
  • Eicosapentaenoic Acid
  • Docosapentaenoic Acid
ispartof: Annals of internal medicine, August 2, 2011, Vol.155(3), pp.160-170
description: BACKGROUNDFew previous studies have evaluated associations between long-chain ω-3 fatty acids and incidence of congestive heart failure (CHF), and those that have are typically based on diet questionnaires and yield conflicting results. Circulating fatty acid concentrations provide objective biomarkers of exposure. OBJECTIVETo determine whether plasma phospholipid concentrations of long-chain ω-3 fatty acids, including eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA), were associated with incident CHF. DESIGNProspective cohort study. SETTING4 U.S. communities. PATIENTS2735 U.S. adults without prevalent heart disease who were enrolled in the Cardiovascular Health Study from 1992 to 2006. MEASUREMENTSPlasma phospholipid fatty acid concentrations and other cardiovascular risk factors were measured in 1992 by using standardized methods. Relationships with incident CHF (555 cases during 26 490 person-years, adjudicated by using medical records) were assessed by using Cox proportional hazards models. RESULTSAfter multivariate adjustment, plasma phospholipid EPA concentration was inversely associated with incident CHF; risk was approximately 50% lower in the highest versus the lowest quartile (hazard ratio [HR], 0.52 [95% CI, 0.38 to 0.72]; P for trend = 0.001). In similar analyses, trends toward lower risk were seen for DPA (HR, 0.76 [CI, 0.56 to 1.04]; P for trend = 0.057) and total long-chain ω-3 fatty acids (HR, 0.70 [CI, 0.49 to 0.99]; P for trend = 0.062) but not for DHA (HR, 0.84 [CI, 0.58 to 1.21]; P for trend = 0.38). In analyses censored to the middle of follow-up (7 years) to minimize exposure misclassification over time, multivariate-adjusted HRs were 0.48 for EPA (CI, 0.32 to 0.71; P for trend = 0.005), 0.61 for DPA (CI, 0.39 to 0.95; P for trend = 0.033), 0.64 for DHA (CI, 0.40 to 1.04; P for trend = 0.057), and 0.51 for total ω-3 fatty acids (CI, 0.32 to 0.80; P for trend = 0.003). LIMITATIONSTemporal changes in fatty acid concentrations over time may have caused underestimation of associations. Unmeasured or imperfectly measured covariates may have caused residual confounding. CONCLUSIONCirculating individual and total ω-3 fatty acid concentrations are associated with lower incidence of CHF in older adults. PRIMARY FUNDING SOURCENational Institutes of Health.
language: eng
source:
identifier: E-ISSN: 1539-3704 ; DOI: 10.7326/0003-4819-155-3-201108020-00006
fulltext: fulltext
issn:
  • 15393704
  • 1539-3704
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titleCirculating long-chain ω-3 fatty acids and incidence of congestive heart failure in older adults: the cardiovascular health study: a cohort study.
creatorMozaffarian, Dariush ; Lemaitre, Rozenn N ; King, Irena B ; Song, Xiaoling ; Spiegelman, Donna ; Sacks, Frank M ; Rimm, Eric B ; Siscovick, David S
contributorMozaffarian, Dariush (correspondence author) ; Mozaffarian, Dariush (record owner)
ispartofAnnals of internal medicine, August 2, 2011, Vol.155(3), pp.160-170
identifierE-ISSN: 1539-3704 ; DOI: 10.7326/0003-4819-155-3-201108020-00006
subjectAged–Blood ; Biomarkers–Blood ; Docosahexaenoic Acids–Blood ; Eicosapentaenoic Acid–Blood ; Fatty Acids, Omega-3–Blood ; Fatty Acids, Unsaturated–Blood ; Feeding Behavior–Epidemiology ; Heart Failure–Epidemiology ; Humans–Epidemiology ; Incidence–Epidemiology ; Proportional Hazards Models–Epidemiology ; Prospective Studies–Epidemiology ; Risk Factors–Epidemiology ; Abridged ; Biomarkers ; Fatty Acids, Omega-3 ; Fatty Acids, Unsaturated ; Docosahexaenoic Acids ; Eicosapentaenoic Acid ; Docosapentaenoic Acid
descriptionBACKGROUNDFew previous studies have evaluated associations between long-chain ω-3 fatty acids and incidence of congestive heart failure (CHF), and those that have are typically based on diet questionnaires and yield conflicting results. Circulating fatty acid concentrations provide objective biomarkers of exposure. OBJECTIVETo determine whether plasma phospholipid concentrations of long-chain ω-3 fatty acids, including eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA), were associated with incident CHF. DESIGNProspective cohort study. SETTING4 U.S. communities. PATIENTS2735 U.S. adults without prevalent heart disease who were enrolled in the Cardiovascular Health Study from 1992 to 2006. MEASUREMENTSPlasma phospholipid fatty acid concentrations and other cardiovascular risk factors were measured in 1992 by using standardized methods. Relationships with incident CHF (555 cases during 26 490 person-years, adjudicated by using medical records) were assessed by using Cox proportional hazards models. RESULTSAfter multivariate adjustment, plasma phospholipid EPA concentration was inversely associated with incident CHF; risk was approximately 50% lower in the highest versus the lowest quartile (hazard ratio [HR], 0.52 [95% CI, 0.38 to 0.72]; P for trend = 0.001). In similar analyses, trends toward lower risk were seen for DPA (HR, 0.76 [CI, 0.56 to 1.04]; P for trend = 0.057) and total long-chain ω-3 fatty acids (HR, 0.70 [CI, 0.49 to 0.99]; P for trend = 0.062) but not for DHA (HR, 0.84 [CI, 0.58 to 1.21]; P for trend = 0.38). In analyses censored to the middle of follow-up (7 years) to minimize exposure misclassification over time, multivariate-adjusted HRs were 0.48 for EPA (CI, 0.32 to 0.71; P for trend = 0.005), 0.61 for DPA (CI, 0.39 to 0.95; P for trend = 0.033), 0.64 for DHA (CI, 0.40 to 1.04; P for trend = 0.057), and 0.51 for total ω-3 fatty acids (CI, 0.32 to 0.80; P for trend = 0.003). LIMITATIONSTemporal changes in fatty acid concentrations over time may have caused underestimation of associations. Unmeasured or imperfectly measured covariates may have caused residual confounding. CONCLUSIONCirculating individual and total ω-3 fatty acid concentrations are associated with lower incidence of CHF in older adults. PRIMARY FUNDING SOURCENational Institutes of Health.
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titleCirculating long-chain ω-3 fatty acids and incidence of congestive heart failure in older adults: the cardiovascular health study: a cohort study.
descriptionBACKGROUNDFew previous studies have evaluated associations between long-chain ω-3 fatty acids and incidence of congestive heart failure (CHF), and those that have are typically based on diet questionnaires and yield conflicting results. Circulating fatty acid concentrations provide objective biomarkers of exposure. OBJECTIVETo determine whether plasma phospholipid concentrations of long-chain ω-3 fatty acids, including eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA), were associated with incident CHF. DESIGNProspective cohort study. SETTING4 U.S. communities. PATIENTS2735 U.S. adults without prevalent heart disease who were enrolled in the Cardiovascular Health Study from 1992 to 2006. MEASUREMENTSPlasma phospholipid fatty acid concentrations and other cardiovascular risk factors were measured in 1992 by using standardized methods. Relationships with incident CHF (555 cases during 26 490 person-years, adjudicated by using medical records) were assessed by using Cox proportional hazards models. RESULTSAfter multivariate adjustment, plasma phospholipid EPA concentration was inversely associated with incident CHF; risk was approximately 50% lower in the highest versus the lowest quartile (hazard ratio [HR], 0.52 [95% CI, 0.38 to 0.72]; P for trend = 0.001). In similar analyses, trends toward lower risk were seen for DPA (HR, 0.76 [CI, 0.56 to 1.04]; P for trend = 0.057) and total long-chain ω-3 fatty acids (HR, 0.70 [CI, 0.49 to 0.99]; P for trend = 0.062) but not for DHA (HR, 0.84 [CI, 0.58 to 1.21]; P for trend = 0.38). In analyses censored to the middle of follow-up (7 years) to minimize exposure misclassification over time, multivariate-adjusted HRs were 0.48 for EPA (CI, 0.32 to 0.71; P for trend = 0.005), 0.61 for DPA (CI, 0.39 to 0.95; P for trend = 0.033), 0.64 for DHA (CI, 0.40 to 1.04; P for trend = 0.057), and 0.51 for total ω-3 fatty acids (CI, 0.32 to 0.80; P for trend = 0.003). LIMITATIONSTemporal changes in fatty acid concentrations over time may have caused underestimation of associations. Unmeasured or imperfectly measured covariates may have caused residual confounding. CONCLUSIONCirculating individual and total ω-3 fatty acid concentrations are associated with lower incidence of CHF in older adults. PRIMARY FUNDING SOURCENational Institutes of Health.
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titleCirculating long-chain ω-3 fatty acids and incidence of congestive heart failure in older adults: the cardiovascular health study: a cohort study.
authorMozaffarian, Dariush ; Lemaitre, Rozenn N ; King, Irena B ; Song, Xiaoling ; Spiegelman, Donna ; Sacks, Frank M ; Rimm, Eric B ; Siscovick, David S
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abstractBACKGROUNDFew previous studies have evaluated associations between long-chain ω-3 fatty acids and incidence of congestive heart failure (CHF), and those that have are typically based on diet questionnaires and yield conflicting results. Circulating fatty acid concentrations provide objective biomarkers of exposure. OBJECTIVETo determine whether plasma phospholipid concentrations of long-chain ω-3 fatty acids, including eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA), were associated with incident CHF. DESIGNProspective cohort study. SETTING4 U.S. communities. PATIENTS2735 U.S. adults without prevalent heart disease who were enrolled in the Cardiovascular Health Study from 1992 to 2006. MEASUREMENTSPlasma phospholipid fatty acid concentrations and other cardiovascular risk factors were measured in 1992 by using standardized methods. Relationships with incident CHF (555 cases during 26 490 person-years, adjudicated by using medical records) were assessed by using Cox proportional hazards models. RESULTSAfter multivariate adjustment, plasma phospholipid EPA concentration was inversely associated with incident CHF; risk was approximately 50% lower in the highest versus the lowest quartile (hazard ratio [HR], 0.52 [95% CI, 0.38 to 0.72]; P for trend = 0.001). In similar analyses, trends toward lower risk were seen for DPA (HR, 0.76 [CI, 0.56 to 1.04]; P for trend = 0.057) and total long-chain ω-3 fatty acids (HR, 0.70 [CI, 0.49 to 0.99]; P for trend = 0.062) but not for DHA (HR, 0.84 [CI, 0.58 to 1.21]; P for trend = 0.38). In analyses censored to the middle of follow-up (7 years) to minimize exposure misclassification over time, multivariate-adjusted HRs were 0.48 for EPA (CI, 0.32 to 0.71; P for trend = 0.005), 0.61 for DPA (CI, 0.39 to 0.95; P for trend = 0.033), 0.64 for DHA (CI, 0.40 to 1.04; P for trend = 0.057), and 0.51 for total ω-3 fatty acids (CI, 0.32 to 0.80; P for trend = 0.003). LIMITATIONSTemporal changes in fatty acid concentrations over time may have caused underestimation of associations. Unmeasured or imperfectly measured covariates may have caused residual confounding. CONCLUSIONCirculating individual and total ω-3 fatty acid concentrations are associated with lower incidence of CHF in older adults. PRIMARY FUNDING SOURCENational Institutes of Health.
doi10.7326/0003-4819-155-3-201108020-00006
urlhttp://search.proquest.com/docview/881086512/
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date2011-08-02