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Comparison of the safety and pharmacokinetics of ST-246® after i.v. infusion or oral administration in mice, rabbits and monkeys.

BACKGROUNDST-246® is an antiviral, orally bioavailable small molecule in clinical development for treatment of orthopoxvirus infections. An intravenous (i.v.) formulation may be required for some hospitalized patients who are unable to take oral medication. An i.v. formulation has been evaluated in... Full description

Journal Title: PloS one 2011, Vol.6(8), p.e23237
Main Author: Chen, Yali
Other Authors: Amantana, Adams , Tyavanagimatt, Shanthakumar R , Zima, Daniela , Yan, X Steven , Kasi, Gopi , Weeks, Morgan , Stone, Melialani A , Weimers, William C , Samuel, Peter , Tan, Ying , Jones, Kevin F , Lee, Daniel R , Kickner, Shirley S , Saville, Bradley M , Lauzon, Martin , Mcintyre, Alan , Honeychurch, Kady M , Jordan, Robert , Hruby, Dennis E , Leeds, Janet M
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0023237
Link: http://search.proquest.com/docview/884848072/?pq-origsite=primo
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title: Comparison of the safety and pharmacokinetics of ST-246® after i.v. infusion or oral administration in mice, rabbits and monkeys.
format: Article
creator:
  • Chen, Yali
  • Amantana, Adams
  • Tyavanagimatt, Shanthakumar R
  • Zima, Daniela
  • Yan, X Steven
  • Kasi, Gopi
  • Weeks, Morgan
  • Stone, Melialani A
  • Weimers, William C
  • Samuel, Peter
  • Tan, Ying
  • Jones, Kevin F
  • Lee, Daniel R
  • Kickner, Shirley S
  • Saville, Bradley M
  • Lauzon, Martin
  • Mcintyre, Alan
  • Honeychurch, Kady M
  • Jordan, Robert
  • Hruby, Dennis E
  • Leeds, Janet M
subjects:
  • Administration, Oral–Administration & Dosage
  • Animals–Adverse Effects
  • Antiviral Agents–Pharmacokinetics
  • Area Under Curve–Administration & Dosage
  • Benzamides–Adverse Effects
  • Biological Availability–Pharmacokinetics
  • Dose-Response Relationship, Drug–Methods
  • Drug Evaluation, Preclinical–Administration & Dosage
  • Female–Adverse Effects
  • Humans–Pharmacokinetics
  • Infusions, Intravenous–Chemically Induced
  • Isoindoles–Chemically Induced
  • Macaca Fascicularis–Chemically Induced
  • Male–Chemically Induced
  • Metabolic Clearance Rate–Chemically Induced
  • Mice–Chemically Induced
  • Mice, Inbred Balb C–Chemically Induced
  • Rabbits–Chemically Induced
  • Time Factors–Chemically Induced
  • Tissue Distribution–Chemically Induced
  • Tremor–Chemically Induced
  • Antiviral Agents
  • Benzamides
  • Isoindoles
  • St-246
ispartof: PloS one, 2011, Vol.6(8), p.e23237
description: BACKGROUNDST-246® is an antiviral, orally bioavailable small molecule in clinical development for treatment of orthopoxvirus infections. An intravenous (i.v.) formulation may be required for some hospitalized patients who are unable to take oral medication. An i.v. formulation has been evaluated in three...
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0023237
fulltext: fulltext
issn:
  • 19326203
  • 1932-6203
url: Link


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titleComparison of the safety and pharmacokinetics of ST-246® after i.v. infusion or oral administration in mice, rabbits and monkeys.
creatorChen, Yali ; Amantana, Adams ; Tyavanagimatt, Shanthakumar R ; Zima, Daniela ; Yan, X Steven ; Kasi, Gopi ; Weeks, Morgan ; Stone, Melialani A ; Weimers, William C ; Samuel, Peter ; Tan, Ying ; Jones, Kevin F ; Lee, Daniel R ; Kickner, Shirley S ; Saville, Bradley M ; Lauzon, Martin ; Mcintyre, Alan ; Honeychurch, Kady M ; Jordan, Robert ; Hruby, Dennis E ; Leeds, Janet M
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ispartofPloS one, 2011, Vol.6(8), p.e23237
identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0023237
subjectAdministration, Oral–Administration & Dosage ; Animals–Adverse Effects ; Antiviral Agents–Pharmacokinetics ; Area Under Curve–Administration & Dosage ; Benzamides–Adverse Effects ; Biological Availability–Pharmacokinetics ; Dose-Response Relationship, Drug–Methods ; Drug Evaluation, Preclinical–Administration & Dosage ; Female–Adverse Effects ; Humans–Pharmacokinetics ; Infusions, Intravenous–Chemically Induced ; Isoindoles–Chemically Induced ; Macaca Fascicularis–Chemically Induced ; Male–Chemically Induced ; Metabolic Clearance Rate–Chemically Induced ; Mice–Chemically Induced ; Mice, Inbred Balb C–Chemically Induced ; Rabbits–Chemically Induced ; Time Factors–Chemically Induced ; Tissue Distribution–Chemically Induced ; Tremor–Chemically Induced ; Antiviral Agents ; Benzamides ; Isoindoles ; St-246
descriptionBACKGROUNDST-246® is an antiviral, orally bioavailable small molecule in clinical development for treatment of orthopoxvirus infections. An intravenous (i.v.) formulation may be required for some hospitalized patients who are unable to take oral medication. An i.v. formulation has been evaluated in three...
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titleComparison of the safety and pharmacokinetics of ST-246® after i.v. infusion or oral administration in mice, rabbits and monkeys.
descriptionBACKGROUNDST-246® is an antiviral, orally bioavailable small molecule in clinical development for treatment of orthopoxvirus infections. An intravenous (i.v.) formulation may be required for some hospitalized patients who are unable to take oral medication. An i.v. formulation has been evaluated in three...
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titleComparison of the safety and pharmacokinetics of ST-246® after i.v. infusion or oral administration in mice, rabbits and monkeys.
authorChen, Yali ; Amantana, Adams ; Tyavanagimatt, Shanthakumar R ; Zima, Daniela ; Yan, X Steven ; Kasi, Gopi ; Weeks, Morgan ; Stone, Melialani A ; Weimers, William C ; Samuel, Peter ; Tan, Ying ; Jones, Kevin F ; Lee, Daniel R ; Kickner, Shirley S ; Saville, Bradley M ; Lauzon, Martin ; Mcintyre, Alan...
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5Biological Availability–Pharmacokinetics
6Dose-Response Relationship, Drug–Methods
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abstractBACKGROUNDST-246® is an antiviral, orally bioavailable small molecule in clinical development for treatment of orthopoxvirus infections. An intravenous (i.v.) formulation may be required for some hospitalized patients who are unable to take oral medication. An i.v. formulation has been evaluated in three...
doi10.1371/journal.pone.0023237
urlhttp://search.proquest.com/docview/884848072/
date2011-01-01